RESUMEN
We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.
Asunto(s)
Antineoplásicos , Molécula de Adhesión Celular Epitelial/metabolismo , Colorantes Fluorescentes , Indoles , Polímeros , Puntos Cuánticos , Animales , Anticuerpos Inmovilizados/química , Anticuerpos Inmovilizados/metabolismo , Antineoplásicos/química , Antineoplásicos/farmacocinética , Antineoplásicos/farmacología , Femenino , Colorantes Fluorescentes/química , Colorantes Fluorescentes/farmacocinética , Colorantes Fluorescentes/farmacología , Células HeLa , Células Hep G2 , Humanos , Indoles/química , Indoles/farmacocinética , Neoplasias Hepáticas/metabolismo , Ratones , Ratones Endogámicos BALB C , Polímeros/química , Polímeros/farmacocinética , Puntos Cuánticos/química , Puntos Cuánticos/metabolismo , Nanomedicina Teranóstica/métodosRESUMEN
We report the bubble dragged microrocket consisting of functionalized multilayer polymer covered asymmetrically by platinum nanoparticles. The microrocket is pushed back during bubble growth over a small step and dragged forward over a big step during bubble explosion. Each bubble explosion induced a shock wave of gas which propagates in water at ultrafast speed. The bubble dragged microrocket can move along an approximate straight line instead of a fluctuating circle which is the trajectory of a bubble-pushed microrocket in most cases, which makes it a promising candidate for drug delivery and simulating rod-shaped bacteria.