RESUMEN
In the title compound, C(14)H(11)N(3)OS·C(2)H(5)OH, the dihedral angle between the pyridine N-C(fused)-C(fused)-C(thio-phene) plane and the plane of the thio-phene ring is 81.9â (3)°, indicating that they are close to perpendicular. The dihedral angle between this pyridine plane and the benzene ring is 1.3â (3)°. The thio-phene ring is disordered over two coplanar orientations with an occupancy ratio of 0.692â (7):0.308â (7), while the ethanol solvent mol-ecule is also disordered over two sets of site in a 0.66â (4):0.34â (4) ratio. In the crystal, chains are formed along the b axis by N-Hâ¯O and O-Hâ¯N inter-actions with adjacent chains being connected through C-Hâ¯N and C-Hâ¯S inter-actions.
RESUMEN
The title compound, C(22)H(18)ClN(3)S, was synthesized by the reaction of 4-chloro-benzaldehyde, tetra-hydro-thio-pyran-4-one and 3-methyl-1-phenyl-1H-pyrazol-5-amine in acetic acid without a catalyst. The pyridine and pyrazole rings are almost coplanar, the dihedral angle between their mean planes being 2.50â (1)°. The thio-pyran ring exhibits an envelope conformation. The crystal packing is stabilized by inter-molecular C-Hâ¯Cl hydrogen bonds and by C-Hâ¯π and π-π inter-actions [centroid-centroid distances of 3.825â (2)â Å between pyridine rings and 3.557â (2)â Å between pyrazole and pyridine rings.
RESUMEN
The title compound, C(28)H(19)NO(2), was synthesized by the reaction of 1,3-benzodioxole-5-carbaldehyde with naphthalen-2-amine catalyzed by thio-salicylic acid in acetic acid. The central dihydropyridine ring adopts a boat conformation. The two planar (r.m.s. deviations = 0.0158 and 0.0552â Å) bicyclic parts make a dihedral angle of 16.16â (5)° with respect to each other. The crystal packing is stabilized by inter-molecular N-Hâ¯O hydrogen bonds and C-Hâ¯π inter-actions.
RESUMEN
The title compound, C(25)H(22)N(2)O(3), was synthesized by the reaction of 3-nitro-benzaldehyde, dimedone and 2-naphthyl-amine in ethanol. In the mol-ecular structure, the cyclo-hexenone ring adopts an envelope conformation, whereas the piperidine ring has a boat conformation. The crystal packing is stabilized by inter-molecular N-Hâ¯O hydrogen bonds.
RESUMEN
The title compound, C(13)H(7)ClN(4)O·C(2)H(6)O, was synthesized by the reaction of 4-chloro-benzaldehyde, malononitrile and 10% sodium hydroxide solution in an aqueous medium. In the crystal structure, the crystal packing is stabilized by inter-molecular N-Hâ¯N, O-Hâ¯O and N-Hâ¯O hydrogen bonds.
RESUMEN
A new reaction of 4-arylidene-3-methylisoxazol-5(4H)-one or 4-arylidene-2-phenyloxazol-5(4H)-one with 2,6-diaminopyrimidin-4(3H)-one is described and a number of new pyrido[2,3-d]pyrimidine-4,7-dione derivatives are synthesized. This protocol has the advantages of good yields, broad substrate scope and simple work-up.
Asunto(s)
Piridonas/síntesis química , Pirimidinas/síntesis química , Pirimidinonas/síntesis química , Microondas , Modelos Moleculares , Piridonas/química , Pirimidinas/química , Pirimidinonas/química , Solventes , TemperaturaRESUMEN
A facile and selective synthesis of N-substituted 2-aminopyridines is accomplished via microwave-assisted multi-component reactions controlled by the basicity of amine and the nature of solvent. In addition, a possible mechanism accounting for the reaction was proposed.
Asunto(s)
Aminopiridinas/química , Aminopiridinas/síntesis química , Aminas/química , Química Orgánica/métodos , Técnicas Químicas Combinatorias , Calefacción , Microondas , Modelos Químicos , Estructura Molecular , Solventes/química , Espectrofotometría Infrarroja , Espectroscopía Infrarroja por Transformada de FourierRESUMEN
The title compound, [Fe(C(5)H(5))(C(17)H(11)BrN(3))], was synthesized by the reaction of 4-bromo-benzaldehyde, acetyl-ferrocene and ammonium acetate in an aqueous medium. The crystal packing is stabilized by inter-molecular N-Hâ¯N hydrogen bonds. The dihedral angles between the phenyl ring and the pyridine and cyclopentadienyl rings are 51.67â (13) and 12.12â (21)°, respectively.
RESUMEN
Reactions of aldehydes, 1,3-indanedione and enaminones were successfully carried out using p-toluene sulfonic acid (p-TsOH) as a catalyst and high-temperature water as a solvent under microwave irradiation. This method provided several advantages such as rapid reaction times, high yields, and a simple workup procedure. In addition, a possible mechanism to account for the reaction was proposed.
Asunto(s)
Calor , Microondas , Quinolinas/síntesis química , Ácidos Sulfónicos/química , Tolueno/química , Agua/química , Catálisis , Quinolinas/químicaRESUMEN
An efficient one-pot, three-component method for the preparation of indeno[1,2-b]quinoline-9,11(6H,10H)-dione, acridine-1,8(2H,5H)-dione and various multi-substituted quinoline-3-carbonitrile derivatives has been developed through the Michael addition to enaminones, which was achieved by both microwave irradiation and conventional heating.
Asunto(s)
Acridinas/síntesis química , Compuestos Heterocíclicos de 4 o más Anillos/química , Nitrilos/síntesis química , Quinolinas/síntesis química , Acridinas/química , Cristalografía por Rayos X , Nitrilos/química , Quinolinas/química , TemperaturaRESUMEN
A simple and efficient synthesis of 2-amino pyrido[2,3-d]pyrimidine derivatives was accomplished via a three-component reaction under microwave irradiation without catalyst. This method had many dramatic advantages such as the short reaction time, high yield, and broad substrate scope, as well as convenient operation. We provide new series of potential biologically active compounds as inhibitors of Cdk4.
Asunto(s)
Quinasa 4 Dependiente de la Ciclina/antagonistas & inhibidores , Inhibidores Enzimáticos/síntesis química , Inhibidores Enzimáticos/farmacología , Piridinas/síntesis química , Piridinas/farmacología , Pirimidinas/síntesis química , Pirimidinas/farmacología , Diseño de Fármacos , Inhibidores Enzimáticos/efectos de la radiación , Microondas , Estructura Molecular , Piridinas/efectos de la radiación , Pirimidinas/efectos de la radiación , Estereoisomerismo , Relación Estructura-ActividadRESUMEN
A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening.