RESUMEN
Vaccines are a unique category of drugs sensitive to temperature and humidity and whose effectiveness directly impacts public health. There has been an increase in vaccine-related adverse events worldwide, particularly in developing countries, attributed to suboptimal temperatures during transport and storage. At the same time, the Internet of Things (IoT) has ushered in a paradigm shift in vaccine information and storage monitoring, enabling continuous 24/7 tracking. This further reduces the dependence on limited human resources and significantly reduces the associated errors and losses. This paper presents an IoT-driven framework that aims to improve the sustainability of medical cold chain management. The framework promotes trust and transparency in vaccine surveillance data by accessing and authenticating IoT devices. The proposed system aims to improve the safety and sustainability of vaccine management. Moreover, we provide detailed insights into the design and hardware components of the proposed framework. In addition, the specific use of the framework in a particular province is highlighted, covering the design of the software platform and the analysis of the hardware equipment.
RESUMEN
Through the merits of the arbitrary three-dimensional (3D) fabrication ability and nanoscale resolution of two-photon polymerization, we demonstrated a fully encircled polymerized microfiber Bragg grating using 3D femtosecond laser nanofabrication. In order to generate strong enough polymer Bragg grating units around the microfiber surface, and to possess a possible smaller unit pitch and structure size, the composition of photoresist and grating dimensions were both experimentally optimized. A fast-curing, high-adhesion, great-heat-resistant acrylate monomer EQ4PETA was chosen as the cross-linking element, and a high-efficiency photoinitiator DETC was used. Along the tapered microfiber with a diameter of 2 microns, dozens of grating units of 300 nm thickness were successively fabricated. The resonance wavelength was approximately 1420 nm, with a unit pitch of 1 µm, slightly different with varying unit pitches. The refractive index sensitivity reached up to ~440 nm/RIU, which is much higher than other microfiber grating sensors. We also measured the temperature and strain sensitivity of this fully encircled microfiber Bragg grating, and this was estimated at 88 pm/°C and 6.3 pm/µÎµ. It is foreseeable that with the continuous progress of fabrication technology, more highly integrated functional optical devices will emerge in the future.