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1.
Zhongguo Gu Shang ; 35(7): 610-4, 2022 Jul 25.
Artículo en Chino | MEDLINE | ID: mdl-35859368

RESUMEN

OBJECTIVE: To investigate the application of high offset femoral stem prosthesis in primary total hip arthroplasty. METHODS: From January 2015 to June 2017, 51 patients with unilateral hip diseases who underwent primary total hip arthroplasty with Corail high offset femoral stem prosthesis(KHO type) were selected for retrospective study, including 20 females and 31 males;the age ranged from 21 to 71 years old with an average of(50.8±13.3) years old. The abduction arm, femoral offset, acetabular offset and the length of lower limbs were measured on the positive X-ray film of hip joint after operation. Harris scores before and after operation and related complications were recorded, and the stability of prosthesis was analyzed. RESULTS: The femoral offset, combined offset and abduction arm of the affected side were significantly greater than those of the healthy side(P<0.05). There was no significant difference in acetabular offset between the affected side and the healthy side (P>0.05). The femoral offset of 17 hips (33.3%) was reconstructed normally, of which 15 cases (88.2%) had equal length of both lower limbs. The femoral offset of 34 hips (66.7%) was greater than that of the healthy side, and 34 cases (100%) had equal length of both lower limbs. All 51 patients were followed up for(42.3±7.3) months. The Harris score increased from 38.0±7.6 before operation to 92.1±3.1 at the final follow-up(P<0.001). CONCLUSION: Although the high offset Corail prosthesis can not normally reconstruct the femoral offset in unilateral primary total hip arthroplasty, it does not affect the reconstruction of the length of lower limbs and the stability of the prosthesis.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Prótesis de Cadera , Adulto , Anciano , Femenino , Estudios de Seguimiento , Articulación de la Cadera/cirugía , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
2.
Nanoscale ; 14(5): 1971-1977, 2022 Feb 03.
Artículo en Inglés | MEDLINE | ID: mdl-35060991

RESUMEN

The formation of high-nuclear silver(I) clusters remains elusive and their potential applications are still underdeveloped. Herein, we report an unprecedented gigantic Ag148 ([Ag148S26Cl30(CCBut)60](SbF6)6) cluster co-templated by Cl- and S2-, which was well-defined by single-crystal X-ray diffraction and high-resolution mass spectrometry. The cluster exhibits a hierarchical structure consisting of fused Ag24X16 kernel, Ag60X20 shell and "cluster of clusters assembling" of four pentagonal concave polyhedral {Ag16X5} units. Furthermore, the silver cluster emits red light at room temperature with a prominent 39.6% QY. The cellular uptake and cytotoxicity indicate that Ag148 induces apoptosis of cancer cells in a dose-dependent manner.


Asunto(s)
Luminiscencia , Neoplasias , Cloruros , Cristalografía por Rayos X , Neoplasias/tratamiento farmacológico , Plata , Sulfuros
3.
Orthop Surg ; 13(6): 1787-1792, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34351063

RESUMEN

OBJECTIVE: To evaluate the predictive values of femoral proximal medullary morphology for the use of subtrochanteric osteotomy (STO) in unilateral Crowe IV developmental dysplasia of the hip (DDH). METHODS: Ninety four patients with unilateral Crowe type IV DDH (59 hips in STO group and 35 hips in the non-STO group) between April 2008 and June 2019 were enrolled. All patients underwent THA using the Pinnacle acetabular shell, ceramic liner and femoral head, the S-ROM stem with proximal sleeve. Three parameters on the standard anteroposterior hip radiographs were measured: the widths of medullary canals at 20 mm above the center of lesser trochanter (CLT),20 mm below the CLT and the isthmus. Canal flare index (CFI), metaphyseal canal flare index (MCFI), diaphyseal canal flare index (DCFI) were calculated. A S-ROM femoral stem was used in all patients during total hip arthroplasty (THA). RESULTS: The CFI and DCFI in the STO group were lower than those in the non-STO group. However, there was no statistical difference in MCFI between the two groups. The receiver operating characteristic (ROC) curves shown that DCFI had the highest area under the curve (AUC), at 0.885. This was followed by the CFI, which had an AUC of 0.847. The AUC of MCFI was 0.579. The optimal threshold for DCFI was 1.44, which lead to a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 0.771, 0.898, 0.869, and 0.818, respectively. For CFI, the optimal threshold was 3.28, resulting in a sensitivity, specificity, PPV, and NPV of 0.829, 0.729, 0.878, and 0.644, respectively. CONCLUSIONS: The DCFI and CFI may be potent indicators in predicting the use of STO in unilateral Crowe IV DDH. The optimal threshold for CFI and DCFI were 3.28 and 1.44 and had good sensitivity and specificity for predicting the use of STO during THA.


Asunto(s)
Artroplastia de Reemplazo de Cadera/métodos , Fémur/cirugía , Luxación Congénita de la Cadera/cirugía , Prótesis de Cadera , Osteotomía/métodos , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
5.
J Chin Med Assoc ; 73(12): 644-6, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-21145513

RESUMEN

We report a case of rare bilateral massive ovarian luteinized follicular cysts in a twin pregnancy. A 28-year-old, gravida 1, para 0, abortus 0 woman was incidentally found to have bilateral massive ovarian cysts (left side, 12 × 10 × 8 cm; right side, 15 × 10 × 6 cm) during the cesarean delivery of a twin pregnancy at 36 weeks of gestation. After 1,950-g and 2,350-g female babies were delivered in good condition, the patient received bilateral oophorectomy. Subsequent histopathology led to the diagnosis of giant bilateral ovarian luteinized follicular cysts.


Asunto(s)
Quistes Ováricos/patología , Folículo Ovárico/patología , Complicaciones del Embarazo/patología , Gemelos , Adulto , Femenino , Humanos , Quistes Ováricos/diagnóstico , Embarazo , Complicaciones del Embarazo/diagnóstico
6.
Acta Biochim Biophys Sin (Shanghai) ; 38(3): 207-12, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16518546

RESUMEN

Nestin, an intermediate filament protein, is expressed in the neural stem cells of the developing central nervous system. This tissue-specific expression is driven by the neural stem cell-specific enhancer in the second intron of the nestin gene. In this study, we showed that the mouse nestin gene was expressed in pluripotent embryonic carcinoma (EC) P19 and F9 cells, not in the differentiated cell types. This cell type-specific expression was conferred by the enhancer in the second intron. Mutation of the conserved POU factor-binding site in the enhancer abolished the reporter gene expression in EC cells. Oct4, a Class V POU factor, was found to be coexpressed with nestin in EC cells. Electrophoretic mobility-shift assays and supershift assays showed that a unique protein-DNA complex was formed specifically with nuclear extracts of EC cells, and Oct4 protein was included. Together, these results suggest the functional relevance between the conserved POU factor-binding site and the expression of the nestin gene in pluripotent EC cells.


Asunto(s)
Regulación del Desarrollo de la Expresión Génica/fisiología , Proteínas de Filamentos Intermediarios/genética , Intrones/genética , Proteínas del Tejido Nervioso/genética , Células Madre Pluripotentes/metabolismo , Animales , Secuencia de Bases , Sitios de Unión/genética , Carcinoma/patología , ADN/genética , ADN/metabolismo , Elementos de Facilitación Genéticos , Proteínas de Filamentos Intermediarios/metabolismo , Ratones , Mutación , Proteínas del Tejido Nervioso/metabolismo , Nestina , Factores del Dominio POU/metabolismo , Células Tumorales Cultivadas
7.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 27(6): 778-81, 2005 Dec.
Artículo en Chino | MEDLINE | ID: mdl-16447657

RESUMEN

Cartilage is a tough, elastic, and fibrous connective tissue, composed of chondrocyte and extracellular matrix (ECM) structural entity. Because of the poor self-regeneration capabilities of chondrocytes, cell transplantation is necessanry once the cartilage is damaged. Traditionally autologous chondrocytes implantation is applied at the damage site, which has many problems such as the losing of its primary characteristics. A well-defined and efficient protocol to direct the differentiation of embryonic stem cells into the chondrocyte will provide a novel choice for cartilage repair. This article reviews some major progresses in this field.


Asunto(s)
Técnicas de Cultivo de Célula/métodos , Diferenciación Celular , Condrocitos/citología , Células Madre Embrionarias/citología , Animales , Proteínas Morfogenéticas Óseas/farmacología , Diferenciación Celular/efectos de los fármacos , Células Cultivadas , Células Madre Embrionarias/efectos de los fármacos , Proteínas de la Matriz Extracelular/farmacología , Humanos , Factor de Crecimiento Transformador beta/farmacología
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