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1.
Front Sociol ; 9: 1386270, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38544792

RESUMEN

[This corrects the article DOI: 10.3389/fsoc.2023.1220438.].

2.
Contraception ; 129: 110302, 2024 01.
Artículo en Inglés | MEDLINE | ID: mdl-37802461

RESUMEN

OBJECTIVES: Long-acting reversible contraception (LARC) initiation has been well-studied and intervened upon. Because LARC requires provider intervention for initiation and removal, it is critical to measure informed choice at the time of desired discontinuation as well. We examined perceptions of access to LARC discontinuation among women at two sites in Burkina Faso, where LARC is the dominant method in the contraceptive mix. STUDY DESIGN: We analyzed data from a 2017-2018 population-based, cross-sectional survey of 281 implant users and 55 intrauterine device users at two sites in Burkina Faso. We measured perceptions of access to LARC discontinuation through survey items assessing whether participants (1) were informed on how to discontinue the method, (2) believed they could have LARC removed without a lot of difficulty, (3) believed cost would be a barrier to discontinuation, (4) had ever attempted to have a provider remove LARC, and (5) successfully had LARC removed. The distribution of these measures was examined in the population and for differences by gravida, parity, domestic partnership, fertility desires, and recency of last childbirth. RESULTS: Thirty-eight (11%) of current LARC users reported that they were not informed on how to discontinue, 56 (17%) believed having their device removed would be difficult, and 54 (16%) believed cost would be a barrier to removal. Of women who attempted removal, providers did not immediately remove LARC on request for 10 (28%). CONCLUSIONS: Findings indicate that LARC uptake is an insufficient measure of reproductive access or choice. Future studies should include patient-centered measures that span the full duration of contraceptive use. IMPLICATIONS: This paper finds that a sizable proportion of LARC users lack information about method discontinuation and perceive or experience barriers to method removal. These findings call for a reconsideration of free and informed contraceptive choice to include the entire duration of contraceptive use, not only the time of method provision.


Asunto(s)
Anticonceptivos Femeninos , Dispositivos Intrauterinos , Anticoncepción Reversible de Larga Duración , Embarazo , Femenino , Humanos , Burkina Faso , Estudios Transversales , Anticoncepción/métodos
3.
Front Sociol ; 8: 1220438, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38098754

RESUMEN

The catastrophe of Russia's war in Ukraine following on the heels of the COVID-19 pandemic and the Black Lives Matter-inspired protests raises the possibility of marked changes in people's gendered experiences in Central-Eastern Europe and Eurasia (CEE&E). Drawing upon recent discussions, events, and publications-with particular attention to Ukrainian voices and reflexivity as to my position as a US-based political scientist mostly trained on Russia-I suggest ways that these developments have begun to, can, and should change gender studies. I raise three questions: (1) Does CEE&E still constitute a meaningful geopolitical context-or region-for understanding gender? (2) Who should have authority to speak about gender in CEE&E? and (3) Have the possibilities for solidarities among feminist activists across CEE&E and beyond CEE&E increased or decreased, and why? Considering these questions, I argue that there is still much to be gained from studying gender in CEE&E as a field if we incorporate intersectional and decolonial lenses and especially if we can keep pushing ourselves through the scholarly debates that have constituted the field. Incorporating this part of the world-elided since Soviet collapse-can help gender studies as a whole deepen and reconsider paradigmatic concepts such as intersectionality, colonialism, and solidarity.

4.
Gerontol Geriatr Med ; 9: 23337214231201138, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37790195

RESUMEN

The Geriatrics 5Ms: Medications, Mind, Mobility, what Matters most and Multicomplexity is a framework to address the complex needs of older adults. Intelligent Voice Assistants (IVAs) are increasingly popular and have potential to support health-related needs of older adults. We utilized previously collected qualitative data on older adults' views of how an IVA may address their health-related needs and ascertained their fit into the Geriatrics 5Ms framework. The codes describing health challenges and potential IVA solutions fit the framework: (1) Medications: difficulty remembering medications. SOLUTION: reminders. (2) Mind: isolation, anxiety, memory loss. SOLUTION: companionship, memory aids. (3) Mobility: barriers to exercise. SOLUTION: incentives, exercise ideas. (4) Matters most: eating healthy foods. SOLUTION: suggest and order nutritious foods, (5) Multicomplexity; managing multimorbidity. SOLUTION: symptom tracking and communicating with health care professionals. Incorporating the 5Ms framework into IVA design can aid in addressing health care priorities of older adults.

5.
Surgery ; 172(5): 1337-1345, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-36038376

RESUMEN

BACKGROUND: Most telemedicine modalities have limited ability to enhance procedural and operative care. We developed a novel system to provide synchronous bidirectional expert mixed reality-enabled virtual procedural mentoring. In this feasibility study, we evaluated mixed reality mentoring of combat casualty care related procedures in a re-perfused cadaver model. METHODS: Novices received real-time holographic mentoring from experts using augmented reality via Hololens (Microsoft Inc, Redmond, WA). The experts maintained real-time awareness of the novice's operative environment using virtual reality via HTC-Vive (HTC Corp, Xindian District, Taiwan). Additional cameras (both environments) and novel software created the immersive, shared, 3-dimensional mixed reality environment in which the novice and expert collaborated. The novices were prospectively randomized to either mixed reality or audio-only mentoring. Blinded experts independently evaluated novice procedural videos using a 5-point Likert scale-based questionnaire. Nonparametric variables were evaluated using the Wilcoxon rank-sum test and comparisons using the χ2 analysis; significance was defined at P < .05. RESULTS: Surgeon and nonsurgeon novices (14) performed 69 combat casualty care-related procedures (38 mixed reality, 31 audio), including various vascular exposures, 4-compartment lower leg fasciotomy, and emergency neurosurgical procedures; 85% were performed correctly with no difference in either group. Upon video review, mixed reality-mentored novices showed no difference in procedural flow and forward planning (3.67 vs 3.28, P = .21) or the likelihood of performing individual procedural steps correctly (4.12 vs 3.59, P = .06). CONCLUSION: In this initial feasibility study, our novel mixed reality-based mentoring system successfully facilitated the performance of a wide variety of combat casualty care relevant procedures using a high fidelity re-perfused cadaver model. The small sample size and limited variety of novice types likely impacted the ability of holographically mentored novices to demonstrate improvement over the audio-only control group. Despite this, using virtual, augmented, and mixed reality technologies for procedural mentoring demonstrated promise, and further study is needed.


Asunto(s)
Realidad Aumentada , Tutoría , Realidad Virtual , Cadáver , Competencia Clínica , Estudios de Factibilidad , Humanos , Tutoría/métodos , Estudios Prospectivos
6.
ASSETS ; 20212021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39022668

RESUMEN

Voice-based Intelligent Virtual Assistants (IVAs) promise to improve healthcare management and Quality of Life (QOL) by introducing the paradigm of hands-free and eye-free interactions. However, there has been little understanding regarding the challenges for designing such systems for older adults, especially when it comes to healthcare related tasks. To tackle this, we consider the processes of care delivery and QOL enhancements for older adults as a collaborative task between patients and providers. By interviewing 16 older adults living independently or semi-independently and 5 providers, we identified 12 barriers that older adults might encounter during daily routine and while managing health. We ultimately highlighted key design challenges and opportunities that might be introduced when integrating voice-based IVAs into the life of older adults. Our work will benefit practitioners who study and attempt to create full-fledged IVA-powered smart devices to deliver better care and support an increased QOL for aging populations.

7.
J Atten Disord ; 24(2): 348-358, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-30924702

RESUMEN

Objective: The objective of this study is to evaluate efficacy and safety of SPN-812 (extended-release viloxazine) for ADHD in children aged 6 to 12 years. Method: In an 8-week study, 222 participants were randomized to placebo or SPN-812 100, 200, 300, or 400 mg/day. Measurements included ADHD Rating Scale (RS)-IV total score and Clinical Global Impression-Severity (CGI-S) and Clinical Global Impression-Improvement (CGI-I) scores. Safety assessments included laboratory and electrocardiogram (ECG) measurements, suicidality monitoring (Columbia-Suicide Severity Rating Scale), and adverse event (AE) reporting. Results: Significant improvements in ADHD-RS-IV total score were observed for 200, 300, and 400 mg dose groups versus placebo (p < .05; effect size [ES] = 0.547, 0.596, and 0.623). CGI-I score for the 300 mg group and CGI-S score for all SPN-812 groups except for 100 mg improved significantly (p < .05) versus placebo. The most frequent AEs (≥15%) were somnolence, headache, and decreased appetite. Conclusion: SPN-812 significantly reduced the severity of ADHD symptoms and was well tolerated. The efficacy and safety of SPN-812 are being investigated in Phase III trials.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Estimulantes del Sistema Nervioso Central , Viloxazina , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/uso terapéutico , Niño , Preparaciones de Acción Retardada/uso terapéutico , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Humanos , Resultado del Tratamiento
8.
J Am Assoc Nurse Pract ; 32(1): 45-51, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31567836

RESUMEN

BACKGROUND: The role of the pediatric nurse practitioner (PNP) has changed since its inception over 50 years ago. Pediatric nurse practitioner practice has evolved from providing outpatient primary care to children to providing complex care in the acute practice environment. PURPOSE: The purpose of this study was to describe whether a difference existed in perceptions of organizational support (POS) of PNPs working in academic and nonacademic institutions and to describe the differences between PNP reporting structures and POS. METHODS: A quantitative cross-sectional design was used with a convenience sample (n = 86) of PNPs from the membership list of the Pediatric Nurse Credentialing Board (PNCB). A formal written request was sent to the PNCB to access their membership after which institutional review board approval was obtained from Case Western Reserve University. Participants received an online cover letter with links to the surveys to be completed. The PNPs were asked to complete a demographic/institution characteristic survey and Eisenberger Perceived Organizational Support Survey (POS). RESULTS: More than 63% of the PNPs participating in this national survey, practicing in both academic and nonacademic affiliated hospitals, had positive perceptions of organizational support. No differences were found between the academic and the nonacademic affiliations. IMPLICATIONS FOR PRACTICE: Because PNPs are integral to the provision of care to children, providing opportunities for PNPs to continue to enhance their clinical skills and practice to the full extent of their scope of practice will only enhance their perceptions of organizational support. This dynamic creates a win-win for the PNP, the institution, the patients they care for, and the US health care system.


Asunto(s)
Profesionales de Enfermería Pediátrica/psicología , Percepción , Lugar de Trabajo/normas , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cultura Organizacional , Profesionales de Enfermería Pediátrica/estadística & datos numéricos , Encuestas y Cuestionarios , Lugar de Trabajo/psicología
9.
J Sch Violence ; 16(4): 376-385, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-27445643

RESUMEN

This paper describes the theoretical foundation, development, and feasibility testing of an online, evidence-based intervention for teen dating violence prevention designed for dissemination. Teen Choices: A Program for Healthy, Non-Violent Relationships relies on the Transtheoretical Model of Behavior Change and expert system technology to deliver assessments and feedback matched to stage of change for using healthy relationship skills. The program also tailors feedback to dating status, risk level, and other key characteristics. Ninety-nine students from high schools in Tennessee and Rhode Island completed a Teen Choices session and 97 completed an 11-item acceptability evaluation. 100% of participants completed the intervention session as intended. Evaluations of the program were favorable. For example, 88.7% agreed the program feedback was easy to understand, and 86.7% agreed that the program could help people develop healthier relationships. Findings provide encouraging evidence of the acceptability and feasibility of this approach to dating violence prevention.

10.
Psychol Violence ; 6(3): 421-432, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27482470

RESUMEN

OBJECTIVE: Teen dating violence is a serious public health problem. A cluster-randomized trial was conducted to assess the efficacy of Teen Choices, a 3-session online program that delivers assessments and individualized guidance matched to dating history, dating violence experiences, and stage of readiness for using healthy relationship skills. For high risk victims of dating violence, the program addresses readiness to keep oneself safe in relationships. METHOD: Twenty high schools were randomly assigned to the Teen Choices condition (n=2,000) or a Comparison condition (n=1,901). Emotional and physical dating violence victimization and perpetration were assessed at 6 and 12 months in the subset of participants (total n=2,605) who reported a past-year history of dating violence at baseline, and/or who dated during the study. RESULTS: The Teen Choices program was associated with significantly reduced odds of all four types of dating violence (adjusted ORs ranging from .45 to .63 at 12 months follow-up). For three of the four violence outcomes, participants with a past-year history of that type of violence benefited significantly more from the intervention than students without a past-year history. CONCLUSIONS: The Teen Choices program provides an effective and practicable strategy for intervention for teen dating violence prevention.

11.
J Am Assoc Nurse Pract ; 28(7): 370-8, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-26488528

RESUMEN

PURPOSE: Nurse practitioners (NPs) deliver a wide array of healthcare services in a variety of settings. The purpose of this study was to examine the practice patterns and organizational commitment of inpatient NPs. METHODS: A quantitative design was used with a convenience sample (n = 183) of NPs who attended the American Association of Nurse Practitioners (AANP) national conference. The NPs were asked to complete a demographic questionnaire, the Practice Patterns of Acute Nurse Practitioners tool and the Organizational Commitment Questionnaire. CONCLUSIONS: Over 85% of inpatient practice time consists of direct and indirect patient care activities. The remaining nonclinical activities of education, research, and administration were less evident in the NP's workweek. This indicates that the major role of inpatient NPs continues to be management of acutely ill patients. Moderate commitment was noted in the Organizational Commitment Questionnaire. IMPLICATIONS FOR PRACTICE: Supportive hospital/nursing leadership should acknowledge the value of the clinical and nonclinical roles of inpatient NPs as they can contribute to the operational effectiveness of their organization. By fostering the organizational commitment behaviors of identification, loyalty, and involvement, management can reap the benefits of these professionally dedicated providers.


Asunto(s)
Satisfacción en el Trabajo , Enfermeras Practicantes/psicología , Servicio de Enfermería en Hospital/normas , Pautas de la Práctica en Medicina/normas , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios
12.
Acad Psychiatry ; 40(2): 328-36, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25749919

RESUMEN

The authors describe the Tulane Model for teaching cultural competence to psychiatry residents in order to outline an innovative approach to curricula development in academic psychiatry. The authors focus on the didactic experience that takes place during the first and second postgraduate years and present seven core concepts that should inform the emerging clinician's thinking in the formulation of every clinical case. The authors discuss the correspondence between each core concept and the Outline for Cultural Formulation, introduced in Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV and updated in DSM-5. The authors illustrate how each of the core concepts is utilized as a guideline for teaching residents a process for eliciting culturally relevant information from their patients and their personal histories and how to apply that knowledge in the assessment and treatment of patients in clinical settings.


Asunto(s)
Comparación Transcultural , Competencia Cultural/educación , Internado y Residencia , Psiquiatría/educación , Curriculum , Educación de Postgrado en Medicina , Humanos , Trastornos Mentales/diagnóstico , Trastornos Mentales/terapia , Modelos Educacionales
13.
Appl Nurs Res ; 27(2): 147-50, 2014 May.
Artículo en Inglés | MEDLINE | ID: mdl-24637106

RESUMEN

Nursing approaches to care as based on Katharine Kolcaba's (2003) middle range nursing theory of comfort are discussed in reference to patients' suffering from symptoms related to the discomfort from cardiac syndromes. The specific intervention of "quiet time" is described for its potential use within this population as a comfort measure that addresses Kolcaba's four contexts of comfort: physical, psychospiritual, environmental and sociocultural. Without realizing it, many nurses may practice within Kolcaba's theoretical framework to promote patient comfort. Explicit applications of comfort theory can benefit nursing practice. Using comfort theory in research can provide evidence for quiet time intervention with cardiac patients.


Asunto(s)
Síndrome Coronario Agudo/enfermería , Dolor en el Pecho/enfermería , Atención a la Salud , Servicio de Urgencia en Hospital , Enfermería Holística , Ruido , Atención a la Salud/normas , Servicio de Urgencia en Hospital/normas , Humanos , Masculino , Modelos de Enfermería , Ruido/prevención & control , Ohio
14.
J Med Radiat Sci ; 61(4): 217-224, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25598974

RESUMEN

INTRODUCTION: Palliative patients with metastatic bone pain endure long waiting times and multiple visits to radiation therapy departments for treatment. This can prolong suffering and may be a factor in patients consenting for treatment. Rapid Access Palliative Clinics (RAPC) have been established around the world to provide a multidisciplinary approach to consultation, simulation and treatment on the same day. This paper describes the implementation and evaluation of a RAPC at Waikato Regional Cancer Centre (WRCC) by reducing the time from referral to first specialist appointment (FSA). METHODS: The structure and process for the RAPC day was outlined and the roles of staff were defined. A retrospective study was undertaken of the 261 consecutive patients seen in the RAPC from April 2009 to April 2013. Tracking sheets were created to record patient information at the initial consultation. Follow-up telephone calls were used to assess the patient post-treatment. Patient information was entered into a database. RESULTS: A total of 226 patients received radiation therapy treatment to 307 sites. All patients were seen within 1 week of referral. Sixty-three per cent of patients were simulated and treated on the same day. The change in radiation therapy fractionation prescriptions was statistically significant (P = 0.0012). There was a statistically significant difference between initial and follow-up pain scores (P < 0.0001). CONCLUSION: Evaluation of the clinic has shown that it compares favourably with similar international clinics. The RAPC has decreased the referral to FSA for palliative radiation therapy and reduced the number of visits the patient has to endure due to an increase in single fraction prescriptions. This has resulted in rapid reduction in pain for the majority of patients.

15.
Popul Health Manag ; 16(6): 373-80, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23676122

RESUMEN

This study provides a demonstration of how published intervention outcomes can be used to create benchmarks for wellness programs for comparison of a case study. Case study results can then be applied by decision makers to adopt and evaluate the relative effectiveness of wellness programs. This case study assessed outcomes from Transtheoretical Model (TTM) computer-tailored interventions (CTIs) on 6 behaviors over a 5-year period. Results were compared with outcomes from a series of TTM randomized controlled trials and a representative review of workplace wellness interventions. The case study included 6544 employees, their spouses, and adult dependents who participated in a multicomponent CTI that assessed health risks and provided tailored feedback. Case study results were compared with 26 outcomes from 14 randomized controlled TTM-based CTIs, and with results from a published review of worksite-based wellness programs. The outcomes of the dissemination study were comparable to the average results of the TTM-based randomized controlled trials on stress and depression but exceeded the averages on smoking, healthy eating, fruit and vegetable consumption, and exercise by 16.4% to 44.8%. The dissemination study also exceeded by 89.3% to 7 times the average results of the workplace wellness interventions. The comparisons applied in this project represent a demanding test of the effectiveness of case studies. Length of treatment and choice of treatments are factors that may have contributed to above-average outcomes.


Asunto(s)
Benchmarking , Práctica Clínica Basada en la Evidencia , Promoción de la Salud/normas , Ensayos Clínicos Controlados Aleatorios como Asunto , Adulto , Femenino , Promoción de la Salud/organización & administración , Humanos , Masculino , Persona de Mediana Edad , Estudios de Casos Organizacionales , Conducta de Reducción del Riesgo
16.
J Soc Work Pract Addict ; 12(4): 391-411, 2012 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-23264754

RESUMEN

Studies assessing the efficacy of juvenile justice interventions show small effects on recidivism and other outcomes. This paper describes the development of a prototype of a multimedia computer-tailored intervention ("Rise Above Your Situation"or RAYS) that relies on an evidence-based model of behavior change, the Transtheoretical Model, and expert system technology to deliver assessments, feedback, printed reports, and counselor reports with intervention ideas. In a feasibility test involving 60 system-involved youths and their counselors, evaluations of the program were favorable: 91.7% of youths agreed that the program could help them make positive changes, and 86.7% agreed that the program could give their counselor helpful information about them.

17.
Addict Behav ; 37(9): 1009-18, 2012 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-22591949

RESUMEN

BACKGROUND: Early use of alcohol, tobacco, and other drugs threatens the physical and mental well-being of students and continued use negatively affects many areas of development. An internet-based, tailored intervention based on the Transtheoretical Model of Behavior Change was delivered to middle school students to reduce alcohol, tobacco, and other drug use. This internet-based approach requires very little faculty and staff time, which is efficient given curricular demands. METHODS: Twenty-two middle schools in the United States were matched and randomly assigned to either the intervention or control conditions (N=1590 students who had ever used substances). Participants received one pre-test assessment, three thirty-minute intervention sessions over three months, and two post-test assessments (3 and 14 months after pre-test, respectively). RESULTS: Random effects logistic models showed significant treatment effects for the intervention group when compared to the control group at the 3-month post-test. CONCLUSIONS: This program has the potential to be applied as stand-alone practice or as part of more intensive interventions to promote substance use cessation.


Asunto(s)
Consumo de Bebidas Alcohólicas/prevención & control , Terapia Conductista/métodos , Internet , Prevención del Hábito de Fumar , Trastornos Relacionados con Sustancias/prevención & control , Adolescente , Niño , Femenino , Humanos , Masculino , Salud Rural , Servicios de Salud Escolar , Estudiantes/psicología , Estudiantes/estadística & datos numéricos , Resultado del Tratamiento , Salud Urbana
18.
Popul Health Manag ; 15(5): 276-86, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22352379

RESUMEN

Tailored behavior change programs have proven effective at decreasing health risk factors, but the impact of such programs on participant well-being has not been tested. This randomized trial evaluated the impact of tailored telephone coaching and Internet interventions on health risk behaviors and individual well-being. Exercise and stress management were the primary health risks of interest; improvements in other health risk behaviors were secondary outcomes. A sample of 3391 individuals who reported health risk in the areas of exercise and stress management were randomly assigned to 3 groups: telephonic coaching that applied Transtheoretical Model (TTM) tailoring for exercise and minimal tailoring (stage of change) for stress management; an Internet program that applied TTM tailoring for stress management and minimal tailoring for exercise; or a control group that received an assessment only. Participants were administered the Well-Being Assessment and, at baseline, had relatively low well-being scores (mean, 60.9 out of 100 across all groups). At 6 months, a significantly higher percentage of both treatment groups progressed to the Action stage for exercise, stress management, healthy diet, and total number of health risks, compared to the control group. Both treatment groups also demonstrated significantly greater improvements on overall well-being and the domains of emotional health, physical health, life evaluation, and healthy behaviors. There were no differences between the groups for 2 well-being domains: basic access to needs and work environment. These results indicate that scalable, tailored behavior change programs can effectively reduce health risk and accrue to improved well-being for participants.


Asunto(s)
Adaptación Psicológica , Conductas Relacionadas con la Salud , Promoción de la Salud/métodos , Estado de Salud , Conducta de Reducción del Riesgo , Asunción de Riesgos , Femenino , Indicadores de Salud , Humanos , Masculino , Persona de Mediana Edad , Motivación , Estudios Prospectivos , Psicometría , Medición de Riesgo , Estrés Psicológico/prevención & control
19.
Neurobiol Aging ; 33(8): 1843.e9-17, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22300950

RESUMEN

Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD.


Asunto(s)
Enfermedad de Alzheimer/genética , Vía Clásica del Complemento/genética , Proteínas del Sistema Complemento/genética , Predisposición Genética a la Enfermedad/epidemiología , Predisposición Genética a la Enfermedad/genética , Polimorfismo de Nucleótido Simple/genética , Anciano , Anciano de 80 o más Años , Comorbilidad , Europa (Continente)/epidemiología , Femenino , Marcadores Genéticos/genética , Variación Genética , Humanos , Degeneración Macular , Masculino , Persona de Mediana Edad , Prevalencia , Medición de Riesgo
20.
J Occup Environ Med ; 53(7): 735-42, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21691220

RESUMEN

OBJECTIVE: To develop a presenteeism assessment, the Well-Being Assessment for Productivity (WBA-P), that provides an informative evaluation of job performance loss due to well-being related barriers. METHOD: The WBA-P was developed using exploratory and confirmatory factor analysis using survey data from 1827 employed individuals. Evidence of criterion-related validity was established using multivariate analysis of variance across measures of health and well-being. RESULTS: A hierarchical, two-factor model demonstrated good fit and included factors capturing productivity loss from personal reasons (WBA-PP) and work environment (WBA-PW). Significant interactions existed between these and previously validated presenteeism measures with respect to physical and emotional health, risk factors, and life evaluation. CONCLUSIONS: This initial psychometric evidence suggests that the WBA-P and its subscales are valid measures of presenteeism that capture actionable well-being-related performance barriers.


Asunto(s)
Absentismo , Eficiencia , Encuestas Epidemiológicas , Salud Laboral , Psicometría/métodos , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Encuestas y Cuestionarios
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