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8.
Cancer Treat Rev ; 39(5): 421-9, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23375558

RESUMEN

Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin who has high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and a poor survival. Its incidence has increased during the past twenty years. The studies published from 2008 to early 2012 have introduced interesting changes in the understanding of its epidemiology, pathogenesis and consequently in the diagnostic codes and the therapeutic approach. Early and detailed nodal diagnosis with posterior multidisciplinary decision is mandatory. Surgery and Radiotherapy play a fundamental role in the management of this tumor. Both are associated with improved locoregional control and disease free survival; but patients continue to have distant failure because, currently, there is no effective systemic treatment available. Consequently, there remain controversies about its appropriate management, and this review is an attempt to contribute to their clarification.


Asunto(s)
Carcinoma de Células de Merkel/diagnóstico , Carcinoma de Células de Merkel/terapia , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/terapia , Carcinoma de Células de Merkel/patología , Humanos , Neoplasias Cutáneas/patología
9.
Abdom Imaging ; 37(6): 1041-65, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22349805

RESUMEN

Integrated positron emission tomography-computed tomography (PET-CT) represents a major technologic advance in oncologic imaging of patients with gynecologic malignancies, since it improves localization of regions of increased 18F-fluorodeoxyglucose (FDG) uptake and staging/restaging accuracy by allowing a near-simultaneous acquisition of co-registered, spatially matched metabolic and anatomic data in the same examination. However, physiologic processes, normal variants, and many benign lesions within the pelvis can accumulate FDG and may be confused with malignant neoplasms. Conversely, false-negative results due to malignancies with low FDG uptake can pose a diagnostic challenge in patients with gynecologic cancer. With the increased use of PET-CT in patients with gynecologic malignancies, misinterpretation of these potential pitfalls can have significant implications and alter staging/restaging and patient management. In this article, we review these potential pitfalls in integrated PET-CT of the pelvis in patients with gynecologic cancer.


Asunto(s)
Neoplasias de los Genitales Femeninos/diagnóstico , Imagen Multimodal , Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos X , Carcinoma de Células Escamosas/epidemiología , Carcinoma de Células Escamosas/metabolismo , Protocolos Clínicos , Femenino , Fluorodesoxiglucosa F18/metabolismo , Neoplasias de los Genitales Femeninos/epidemiología , Humanos , Imagen Multimodal/métodos , Posicionamiento del Paciente , Embolia Pulmonar/epidemiología , Radiofármacos/metabolismo , Neoplasias del Cuello Uterino/diagnóstico
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