RESUMEN
In this study, Mycobacterium tuberculosis complex was detected by BD ProbeTec ET system in 4716 respiratory and 167 nonrespiratory samples [mostly (98%) smear negative). Sensitivity, specificity, positive and negative predictive values were 81.8%, 98.3, 85.1 and 97.9 for respiratory and 100%, 96.2, 64.7 and 100, for nonrespiratory samples, respectively. Among 149 (3.1%) ProbeTec DTB positive and culture negative samples, 72 (65 respiratory and seven nonrespiratory) (48.3%) were recovered from the patients who were evaluated as having TB infection. The system has been found as useful in early diagnosis of tuberculosis infection in association with the clinical, radiological and histopathological findings.
Asunto(s)
Técnicas Bacteriológicas/instrumentación , Mycobacterium tuberculosis/aislamiento & purificación , Juego de Reactivos para Diagnóstico , Esputo/microbiología , Tuberculosis Pulmonar/diagnóstico , Técnicas de Tipificación Bacteriana , Técnicas Bacteriológicas/métodos , Líquidos Corporales/microbiología , Líquido Cefalorraquídeo/microbiología , Humanos , Derrame Pleural/microbiología , Valor Predictivo de las Pruebas , Sensibilidad y Especificidad , Tuberculosis Pulmonar/microbiología , Orina/microbiologíaAsunto(s)
Alendronato/efectos adversos , Asma/inducido químicamente , Conservadores de la Densidad Ósea/efectos adversos , Alendronato/administración & dosificación , Hipersensibilidad a las Drogas/etiología , Femenino , Humanos , Persona de Mediana Edad , Osteoporosis Posmenopáusica/tratamiento farmacológicoRESUMEN
Erythropoietin, the major humoral regulator of red cell production, was reported to stimulate various levels of megakaryocytopoiesis. We investigated levels of thrombopoietin (TPO) and erythropoietin (EPO) in patients with reactive thrombocytosis (RT) and clonal thrombocytosis (CT). 17 patients with RT and 18 patients with CT and 15 healthy subjects were enrolled into the study. TPO levels were higher in both patient groups than the controls. EPO levels were significantly higher than these in reactive thrombocytosis and in controls (p < 0.05). We suggest that besides TPO, EPO may play an important role in the pathogenesis of RT.
Asunto(s)
Eritropoyetina/sangre , Trombocitosis/etiología , Adulto , Anciano , Recuento de Células Sanguíneas , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trombocitosis/sangre , Trombocitosis/clasificación , Trombopoyesis , Trombopoyetina/sangreRESUMEN
Behçet's disease (BD) is a systemic remitting vasculitis characterized by orogenital ulceration and uveitis. The disease is not associated with specific laboratory abnormalities. Hence, the activity of BD is generally assessed by clinical findings and--to some extent--by nonspecific markers of inflammation. This study was performed to investigate the relative efficiency of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serumamyloid A protein (SAA), and beta 2-microglobulin (beta 2-m) levels as markers of disease activity in patients with BD. The study population consisted of 20 patients with active BD, 23 patients with inactive BD, and 27 healthy adults serving as the control group. Serum beta 2-m, SAA, ESR, and CRP levels of patients with BD were found to be significantly higher than those in the healthy control group. They were also higher in patients with active disease than in those in remission and controls. The levels of SAA. ESR, and CRP in inactive patients were also significantly higher than the controls. No statistically significant difference was noted between beta 2-m levels of patients with inactive BD and healthy controls. Serum beta 2-m levels can beregarded as a more discriminative marker of activation in BD. The high diagnostic value of SAA levels indicate that it can also be accepted as a marker of disease activity in BD.
