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1.
J Laryngol Otol ; 128(1): 43-8, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-24451682

RESUMEN

OBJECTIVE: To investigate the effectiveness of pomegranate extract as protection against aminoglycoside ototoxicity. DESIGN: Prospective, randomised, controlled, experimental study. SUBJECTS: Eighteen Wistar albino rats were randomly allocated to 5 days of either: saline injections; gentamicin injections; or pomegranate extract (100 µl/day via gavage) plus gentamicin injections. Distortion product otoacoustic emissions were tested before treatment and on day 3. After treatment, reactive oxygen species levels were measured in each rat's right cochlea and right kidney via chemiluminescence. RESULTS: Baseline emission amplitudes were similar. Post-treatment emissions differed significantly in the two treatment groups (p < 0.001). Cochlear reactive oxygen species levels were significantly higher in the gentamicin group (mean ± standard deviation, 316.6 ± 36.5 relative light units per mg) than the gentamicin plus pomegranate extract group (240 ± 24.6 relative light units per mg) (p = 0.004); control group levels were 119.1 ± 10.3 relative light units per mg. Renal reactive oxygen species levels were similar for the control and gentamicin plus pomegranate extract groups (p = 0.59) but much higher in the gentamicin group (p = 0.004). CONCLUSION: Concurrent systemic pomegranate extract administration reduced reactive oxygen species level increases and otoacoustic emission changes, following aminoglycoside injection.


Asunto(s)
Aminoglicósidos/efectos adversos , Antibacterianos/efectos adversos , Cóclea/efectos de los fármacos , Gentamicinas/efectos adversos , Pérdida Auditiva Sensorineural/prevención & control , Riñón/efectos de los fármacos , Lythraceae , Emisiones Otoacústicas Espontáneas/efectos de los fármacos , Extractos Vegetales/farmacología , Animales , Antioxidantes/farmacología , Cóclea/metabolismo , Femenino , Pérdida Auditiva Sensorineural/inducido químicamente , Riñón/metabolismo , Mediciones Luminiscentes , Estudios Prospectivos , Distribución Aleatoria , Ratas , Ratas Wistar , Especies Reactivas de Oxígeno/metabolismo
2.
J Laryngol Otol ; 126(8): 784-8, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22804851

RESUMEN

OBJECTIVE: To compare mucosal and bony measurements in patients with congenital and traumatic nasal septum deviation and compensatory inferior turbinate hypertrophy. METHODS: The study examined 50 patients with nasal septum deviation (25 congenital and 25 traumatic) and compensatory inferior turbinate hypertrophy in the contralateral nasal cavity, confirmed by computed tomography. RESULTS: The study compared inferior turbinate measurements on the concave and convex sides of the septum, in the congenital and traumatic groups. MEASUREMENTS COMPRISED: the shortest distance from the median line to the medial border of the conchal bone; the distances from the most medial part of the conchal mucosa and the conchal bone to the lateral line; the projection angle of the inferior turbinate; and the widest parts of the whole inferior turbinate and the inferior turbinate conchal bone. The differences between the concave and convex side measurements were compared in the congenital group versus the traumatic group; for three measurements, the difference between these two groups was statistically significant (p < 0.05). CONCLUSION: The present study findings suggest that the conchal bone has a marked influence on nasal patency in patients with congenital septal deviation. These findings supported the decision to excise the inferior turbinate bone at the time of septoplasty, especially when treating congenital septal deviation.


Asunto(s)
Cavidad Nasal/anatomía & histología , Obstrucción Nasal/etiología , Tabique Nasal/anomalías , Deformidades Adquiridas Nasales/complicaciones , Cornetes Nasales/patología , Adolescente , Adulto , Femenino , Humanos , Hipertrofia/diagnóstico por imagen , Hipertrofia/etiología , Masculino , Persona de Mediana Edad , Cavidad Nasal/diagnóstico por imagen , Cavidad Nasal/cirugía , Obstrucción Nasal/diagnóstico por imagen , Obstrucción Nasal/cirugía , Tabique Nasal/diagnóstico por imagen , Tabique Nasal/cirugía , Deformidades Adquiridas Nasales/diagnóstico por imagen , Deformidades Adquiridas Nasales/cirugía , Tomografía Computarizada por Rayos X , Cornetes Nasales/diagnóstico por imagen , Cornetes Nasales/cirugía
3.
J Laryngol Otol ; 125(4): 370-5, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21349238

RESUMEN

OBJECTIVE: To assess the effect of pomegranate extract on acute inflammation due to myringotomy. DESIGN: Prospective, randomised study. SUBJECTS: Thirty Sprague-Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 µl/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study. RESULTS: Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01). CONCLUSION: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.


Asunto(s)
Antioxidantes/uso terapéutico , Lythraceae , Miringoplastia/efectos adversos , Otitis Externa/prevención & control , Fitoterapia/métodos , Administración Oral , Animales , Evaluación Preclínica de Medicamentos/métodos , Luminiscencia , Otitis Externa/etiología , Otitis Externa/patología , Extractos Vegetales/uso terapéutico , Ratas , Ratas Sprague-Dawley , Especies Reactivas de Oxígeno/metabolismo , Membrana Timpánica/metabolismo , Membrana Timpánica/patología
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