RESUMEN
Alice Alanna Cashin (1870-1939) was a pioneering Australian nurse whose career spanned both conflict and humanitarian service. Born to Irish immigrants in Australia, Cashin trained at St. Vincent's Hospital, Sydney, before expanding her expertise in London and joining the British Red Cross during World War I. Her service included critical roles in France and Egypt, and she was eventually promoted to 'seas-matron' on the HMHS Gloucester Castle. During a torpedo attack by a German U-Boat, Cashin displayed extraordinary bravery, overseeing the evacuation of over 399 patients and ensuring their safety before leaving on the last lifeboat. After the war, she managed a military hospital in England before returning to Australia to care for her ailing father and later her elderly uncle. Cashin's post-war years included a modest stint running a stationery shop and her retirement in Victoria Road. Her exemplary service earned her multiple accolades, including the Star Medal and the Royal Red Cross Medal, the latter being the first awarded to an Australian. She was also honoured with multiple mentions in dispatches and personal invitations to Buckingham Palace. Alice Cashin's legacy is memorialised at the Woronora Cemetery, with her medals and accolades displayed at the ANZAC Memorial in Sydney, reflecting her enduring impact on the nursing profession and her remarkable dedication to service and care.
RESUMEN
PURPOSE OF REVIEW: This manuscript summarizes novel clinical and interventional approaches in the management of chronic, nociceptive, and neuropathic pain. RECENT FINDINGS: Pain can be defined as a feeling of physical or emotional distress caused by an external stimulus. Pain can be grouped into distinct types according to characteristics including neuropathic pain, which is a pain caused by disease or lesion in the sensory nervous system; nociceptive pain, which is pain that can be sharp, aching, or throbbing and is caused by injury to bodily tissues; and chronic pain, which is long lasting or persisting beyond 6 months. With improved understanding of different signaling systems for pain in recent years, there has been an upscale of methods of analgesia to counteract these pathological processes. Novel treatment methods such as use of cannabinoids, stem cells, gene therapy, nanoparticles, monoclonal antibodies, and platelet-rich plasma have played a significant role in improved strategies for therapeutic interventions. Although many management options appear to be promising, extensive additional clinical research is warranted to determine best practice strategies in the future for clinicians.