RESUMEN
Synthesis of new heterocyclic compounds 3a-e containing naphthopyran and selenadiazole as the heterocyclic sub-units in the molecule is achieved using high yielding synthetic protocol. These molecules 3a-e have shown moderate anti-bacterial activity against some gram-positive and gram-negative bacterias.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Azoles/síntesis química , Azoles/farmacología , Naftoles/química , Compuestos de Selenio/síntesis química , Compuestos de Selenio/farmacología , Antibacterianos/química , Azoles/química , Viabilidad Microbiana/efectos de los fármacos , Estructura Molecular , Compuestos de Selenio/química , Relación Estructura-ActividadRESUMEN
Syntheses of novel heterocyclic derivatives of 18-nor-equilenin, namely, (12H-11-oxa-17-thia-15-aza-cyclopenta[a]phenanthrene-16-yl)-hydrazine (4a/b) and its fused [1,2,4]triazolo derivatives6H-5-oxa-7-thia-8,9,10a-triaza-pentaleno[4,5-a]phenanthrene (5a/b), 10-methyl-6H-5-oxa-7-thia-8,9,10a-triaza-pentaleno[4,5-a]phenanthrene (6a/b) and tetrazolo derivatives 1-substituted-6H-5-oxa-7-thia-8,9,10,10a-tetraaza-pentaleno[4,5-a]phenanthrene (7a/b) along with their antibacterial activities are reported.
