1.
N-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium Okeania hirsuta.
Biosci Biotechnol Biochem
; 88(5): 517-521, 2024 Apr 22.
Article
En
| MEDLINE
| ID: mdl-38337185
A new lipopeptide, N-desmethylmajusculamide B (1), was isolated from the Okinawan cyanobacterium Okeania hirsuta along with 2 known compounds majusculamide A (2) and majusculamide B (3). The planar structure of (1) was elucidated by a detailed analysis of mass spectrometry and nuclear magnetic resonance spectra. The absolute configurations of the amino acid residues were determined using Marfey's analysis. The configuration of C-16 in the α-methyl-ß-keto-decanoyl moiety was determined unambiguously to be S by conducting a semisynthesis of N-desmethylmajusculamide B from 3. The cytotoxicity against mouse L1210 leukemia cells was evaluated for majusculamides (1-3).
Cyanobacteria , Lipopeptides , Cyanobacteria/chemistry , Mice , Animals , Lipopeptides/chemistry , Lipopeptides/isolation & purification , Lipopeptides/pharmacology , Cell Line, Tumor , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Antineoplastic Agents/isolation & purification , Magnetic Resonance Spectroscopy