RESUMEN
Kingella kingae infections generally respond well to most beta-lactam antibiotics. We investigated an antibiotic treatment failure in a 3-year-old with K. kingae L3-4 spondylodiscitis. Her disease progressed even after 19 days of high-dose intravenous flucloxacillin. The clinical isolate did not produce a beta-lactamase and despite phenotypic testing and whole-genome sequencing, the mechanism of flucloxacillin resistance remains unknown.
Asunto(s)
Antibacterianos/uso terapéutico , Discitis/diagnóstico , Discitis/microbiología , Farmacorresistencia Bacteriana , Floxacilina/uso terapéutico , Kingella kingae/efectos de los fármacos , Infecciones por Neisseriaceae/tratamiento farmacológico , Preescolar , Femenino , Humanos , Kingella kingae/genética , Infecciones por Neisseriaceae/diagnóstico por imagen , Infecciones por Neisseriaceae/microbiología , Columna Vertebral/diagnóstico por imagen , Columna Vertebral/microbiología , Tomografía Computarizada por Rayos X , Insuficiencia del Tratamiento , Resultado del TratamientoRESUMEN
BACKGROUND: Neisseria are usually harmless inhabitants of otherwise asymptomatic persons' upper respiratory mucosal surfaces. METHOD: It is, therefore, expected that a disturbance in the physiology leads to nongonococcal, non-meningococcal Neisseria becoming pathogenic. RESULT: We report the case of a diabetic man who initially presented with nonspecific symptoms and was later found to have cystitis caused by N. oralis. CONCLUSION: We also review the pertinent literature and discuss available evidence on pathophysiological mechanisms of infection with such commensal bacteria.