ImageCAS: A large-scale dataset and benchmark for coronary artery segmentation based on computed tomography angiography images.

Cardiovascular disease (CVD) accounts for about half of non-communicable diseases. Vessel stenosis in the coronary artery is considered to be the major risk of CVD. Computed tomography angiography (CTA) is one of the widely used noninvasive imaging modalities in coronary artery diagnosis due to its superior image resolution. Clinically, segmentation of coronary arteries is essential for the diagnosis and quantification of coronary artery disease. Recently, a variety of works have been proposed to address this problem. However, on one hand, most works rely on in-house datasets, and only a few works published their datasets to the public which only contain tens of images. On the other hand, their source code have not been published, and most follow-up works have not made comparison with existing works, which makes it difficult to judge the effectiveness of the methods and hinders the further exploration of this challenging yet critical problem in the community. In this paper, we propose a large-scale dataset for coronary artery segmentation on CTA images. In addition, we have implemented a benchmark in which we have tried our best to implement several typical existing methods. Furthermore, we propose a strong baseline method which combines multi-scale patch fusion and two-stage processing to extract the details of vessels. Comprehensive experiments show that the proposed method achieves better performance than existing works on the proposed large-scale dataset. The benchmark and the dataset are published at https://github.com/XiaoweiXu/ImageCAS-A-Large-Scale-Dataset-and-Benchmark-for-Coronary-Artery-Segmentation-based-on-CT.

Deep Learning Assisted Automated Assessment of Thalassaemia from Haemoglobin Electrophoresis Images.

Haemoglobin (Hb) electrophoresis is a method of blood testing used to detect thalassaemia. However, the interpretation of the result of the electrophoresis test itself is a complex task. Expert haematologists, specifically in developing countries, are relatively few in number and are usually overburdened. To assist them with their workload, in this paper we present a novel method for the automated assessment of thalassaemia using Hb electrophoresis images. Moreover, in this study we compile a large Hb electrophoresis image dataset, consisting of 103 strips containing 524 electrophoresis images with a clear consensus on the quality of electrophoresis obtained from 824 subjects. The proposed methodology is split into two parts: (1) single-patient electrophoresis image segmentation by means of the lane extraction technique, and (2) binary classification (normal or abnormal) of the electrophoresis images using state-of-the-art deep convolutional neural networks (CNNs) and using the concept of transfer learning. Image processing techniques including filtering and morphological operations are applied for object detection and lane extraction to automatically separate the lanes and classify them using CNN models. Seven different CNN models (ResNet18, ResNet50, ResNet101, InceptionV3, DenseNet201, SqueezeNet and MobileNetV2) were investigated in this study. InceptionV3 outperformed the other CNNs in detecting thalassaemia using Hb electrophoresis images. The accuracy, precision, recall, f1-score, and specificity in the detection of thalassaemia obtained with the InceptionV3 model were 95.8%, 95.84%, 95.8%, 95.8% and 95.8%, respectively. MobileNetV2 demonstrated an accuracy, precision, recall, f1-score, and specificity of 95.72%, 95.73%, 95.72%, 95.7% and 95.72% respectively. Its performance was comparable with the best performing model, InceptionV3. Since it is a very shallow network, MobileNetV2 also provides the least latency in processing a single-patient image and it can be suitably used for mobile applications. The proposed approach, which has shown very high classification accuracy, will assist in the rapid and robust detection of thalassaemia using Hb electrophoresis images.

Deep learning based classification of unsegmented phonocardiogram spectrograms leveraging transfer learning.

Objective.Cardiovascular diseases (CVDs) are a main cause of deaths all over the world. This research focuses on computer-aided analysis of phonocardiogram (PCG) signals based on deep learning that can enable improved and timely detection of heart abnormalities. The two widely used publicly available PCG datasets are from the PhysioNet/CinC (2016) and PASCAL (2011) challenges. The datasets are significantly different in terms of the tools used for data acquisition, clinical protocols, digital storages and signal qualities, making it challenging to process and analyze.Approach.In this work, we have used short-time Fourier transform-based spectrograms to learn the representative patterns of the normal and abnormal PCG signals. Spectrograms generated from both the datasets are utilized to perform four different studies: (i) train, validate and test different variants of convolutional neural network (CNN) models with PhysioNet dataset, (ii) train, validate and test the best performing CNN structure on the PASCAL dataset, as well as (iii) on the combined PhysioNet-PASCAL dataset and (iv) finally, the transfer learning technique is employed to train the best performing pre-trained network from the first study with PASCAL dataset.Main results.The first study achieves an accuracy, sensitivity, specificity, precision and F1 scores of 95.75%, 96.3%, 94.1%, 97.52%, and 96.93%, respectively, while the second study shows accuracy, sensitivity, specificity, precision and F1 scores of 75.25%, 74.2%, 76.4%, 76.73%, and 75.42%, respectively. The third study shows accuracy, sensitivity, specificity, precision and F1 scores of 92.7%, 94.98%, 89.95%, 95.3% and 94.6%, respectively. Finally, the fourth study shows a precision of 96.98% on the noisy PASCAL dataset with transfer learning approach.Significance.The proposed approach employs a less complex and relatively light custom CNN model that outperforms most of the recent competing studies by achieving comparatively high classification accuracy and precision, making it suitable for screening CVDs using PCG signals.