[Etiologic factors in development of inflammatory diseases (cheilitis) of the lips].

Last years the number of patients affected with lips' pathologies has been significantly increased that could be caused by different exogenic (chemical, biological, pharmacological and toxic substances etc.) and endogenic factors. Therefore, considering the above-mentioned etiologic factors, the aim of our study was identification and differentiation of different types of Cheilitis and basing on the study of their pathogenesis, to perform differential diagnostics and to systematize them. In certain cases, cheilitis appeared to be the early manifestations of diseases of different organs or organ systems on lips, laying the great responsibility on the Doctor-Stomatologists, who together with the other appropriate specialists is obliged to perform diagnostics of general (background) diseases in time; to make differential diagnostics and to plan the further and target therapy.

[Prostate-specific antigen in serum and prostate epithelium in benign prostatic hyperplasia].

The aim of our investigation was the simultaneous study of concentration of prostate-specific antigen (PSA) in serum and its immune-histochemical expression in the adenomatous prostatic tissue. 50 patients have been investigated. In 48 patients benign prostatic hyperplasia (BPH) has been diagnosed, and 2 patients served as controls. Investigated patients were divided by 2 groups: 1st group--patients with moderate IPSS (n=6); 2nd group--patients with expressed IPSS (n=42). The results of our investigations shown that at any variant of BPH lumine epithelium, as a rule, were PSA-positive. Negativity of immune-histochemical reaction was observed in areas of epithelium atypical hyperplasia, when proliferated epithelium is presented by basal cells. Expression degree varied between weak, moderate and high. The comparison of PSA expression degrees in tissue and its blood levels shown that the change of blood concentrations was more variable, than expression in tissue. Quantitative imbalance between them indicates that determination of blood PSA without immune-histochemical investigation is less reliable and does not give a valuable insight about the essence prostate pathology.

[Peculiarities of immunocompetent cell distribution in the endometrium in the proliferation phase of the normal menstrual cycle].

Quantity and peculiarity of lymphocytes in the endometrium in the proliferation phase of the normal menstrual cycle have been studied. Operative material from 14 women of reproductive age with the diagnosis of carcinoma colli uterine have been investigated. Our investigations included morphometric studies of the character, quantity and localization of the lymphocytes. General quantity of immunocompetent cells were represented by CD3+ T lymphocytes which exist in all layers of the endometrium, among them predominant was the CD8+T lymphocyte subpopulation. CD20+ B lymphocytes in fact were missing in the epithelium, but in the other layers of the endometrium they were found in insignificant quantity.

[Results of the morphological examination of stomach in the different terms after stitching of a perforation duodenal ulcer].

Analyses of 184 cases of morphological examination of resected part of stomach in the different terms after stitching of a perforative duodenal ulcer is presented. The authors confirm, that ulcerative disease of duodenum and it's various complications including perforation is associated with antrum gastritis in all cases, which has superficial character. The authors are confirming that a gastric metaplasia of a mucosa of duodenum assists to the helicobacterial colonization, which represents one of the main factors of an ulcer formation along with a fast transition of acid gastric contents into the duodenum. The authors consider the gastric metaplasia as preulcerative pathological condition of duodenum.