RESUMEN
Aluminum chloride was tested for its effect on primary T-dependent humoral immune response. The administration of aluminum chloride in the genotoxic dose (0.04 M) caused in mice a profound immunosuppressive effect accompanied by diminished thymic and splenic cellularity. The findings suggest that aluminum chloride possesses marked immunotoxic properties.
Asunto(s)
Compuestos de Aluminio/toxicidad , Cloruros/toxicidad , Bazo/efectos de los fármacos , Linfocitos T/efectos de los fármacos , Cloruro de Aluminio , Animales , Tolerancia Inmunológica , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Pruebas de Mutagenicidad , Bazo/citología , Timo/citología , Timo/efectos de los fármacosRESUMEN
Views of the toxicity of aluminum to man, animals, and plants and on its behavior in the ecosystems with a changing man-made loading have changed in the past 30 years. Aluminum along with its human medical consequences has been found to present problems on the acid soils in world agriculture. To systematize knowledge and to control information on aluminum and its compounds, the reference information system "Ecology and Aluminum Toxicology" whose structure is based on the developed model of an ecological aluminum cycle was designed. Basic information units were identified in a rather wide subject area: "Generation", "Spread", and "Action", which include the information available in the published materials and the data obtained in the authors' experimental studies.