BACKGROUND: Considering conflicting results on the consequences of all types of obesity surgery, we were to summarize them via a systematic review. METHODS: Electronic literature search was done via scientific search engines. After the removal of duplicates and selection of articles of interest, 771 studies were included. RESULTS: Insulin resistance indicators were significantly improved after bariatric surgery. Leptin was also significantly decreased while adiponectin was significantly increased. Although the level of metabolic hormones changed after bariatric surgery, they were not statistically significant. Inflammation indicators were significantly decreased. Significant reduction was also detected in PAI-1 and sICAM-1. CONCLUSIONS: Bariatric surgery is beneficial in morbidly obese patients. Although treating obesity in a surgical way may cause some complications, the weight loss is generally safe and effective.
Bariatric Surgery/methods , Adiponectin/blood , C-Reactive Protein/analysis , Ghrelin/blood , Glucagon-Like Peptide 1/blood , Humans , Insulin/blood , Insulin Resistance , Intercellular Adhesion Molecule-1/blood , Interleukin-6/blood , Leptin/blood , Obesity, Morbid/blood , Obesity, Morbid/surgery , Peptide YY/blood , Plasminogen Activator Inhibitor 1/blood , Tumor Necrosis Factor-alpha/blood
Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review.
