Native myocardial T1 mapping using inversion recovery T1-weighted turbo field echo sequence.

This study proposes the use of the inversion recovery T1-weighted turbo field echo (IR-T1TFE) sequence for myocardial T1 mapping and compares the results obtained with those of the modified Look-Locker inversion recovery (MOLLI) method for accuracy, precision, and reproducibility. A phantom containing seven vials with different T1 values was imaged, thereby comparing the T1 measurements between the inversion recovery spin-echo (IR-SE) technique, MOLLI, and the IR-T1TFE. The accuracy, precision, and reproducibility of the T1-mapping sequences were analyzed in a phantom study. Fifteen healthy subjects were recruited for the in vivo comparison of native myocardial T1 mapping using MOLLI and IR-T1TFE sequences. After myocardium segmentation, the T1 value of the entire myocardium was calculated. In the phantom study, excellent accuracy was achieved using IR-T1TFE for all T1 ranges. MOLLI displayed lower accuracy than IR-T1TFE (p =0.016), substantially underestimating T1 at large T1 values (> 1000 ms). In the in vivo study, the first mean myocardial T1 values ± SD using MOLLI and IR-T1TFE were 1306 ± 70 ms and 1484 ± 28 ms, respectively, and the second were 1297 ± 68 ms and 1474 ± 43 ms, respectively. The native myocardial T1 obtained with MOLLI was lower than that of IR-T1TFE (p < 0.001). The reproducibility of native myocardial T1 mapping within the same sequence was not statistically significant (p = 0.11). This study demonstrates the utility and validity of myocardial T1 mapping using IR-T1TFE, which is a common sequence. This method was found to have high accuracy and reproducibility.

3D phase-sensitive inversion recovery sequence for intracranial vertebrobasilar artery dissection.

BACKGROUND: T1-weighted 3D turbo spin echo (T1W-3D-TSE) sequences with variable refocusing flip angle are commonly used to diagnose intracranial vertebrobasilar artery dissection (iVAD). However, magnetic susceptibility artifacts of the cavernous sinus may cause loss of the basilar and vertebral arteries. This study investigated the effectiveness of a 3D phase-sensitive inversion recovery (3D-PSIR) sequence in reducing magnetic susceptibility artifacts in the cavernous sinus, and its imaging findings for iVAD. METHODS: Twelve volunteers and eleven patients with iVAD were included. Magnetic resonance imaging (MRI) was performed using a 3.0-T MRI system. 3D-PSIR and T1W-3D-TSE sequences were used. Vessel wall defects and contrast-to-noise ratio (CNR) were evaluated. The MRI findings were visually evaluated. RESULTS: In the 3D-PSIR images, one volunteer (8 %) had vessel wall defects, and five (42 %) had vessel wall defects (p = 0.046) in the T1W-3D-TSE images. CNR was higher in 3D-PSIR images for vessel wall-to-lumen, whereas it was higher in T1W-3D-TSE images for vessel wall-to-CSF (p < 0.001). Visual evaluation revealed similar MRI findings between the two sequences. CONCLUSIONS: The 3D-PSIR sequence may be able to improve the vessel wall defects and achieve MRI findings comparable to those of the T1W-3D-TSE sequence in iVAD. The 3D-PSIR sequence can be a useful tool for the imaging-based diagnosis of iVAD.

[Non-electrocardiogram-gated and Non-contrast-enhanced Magnetic Resonance Angiography of the Lower Limb Arteries Using Three-dimensional Multishot T1-weighted Fast-field Echo-Echo Planar Imaging].

We performed a non-electrocardiogram-gated and non-contrast-enhanced magnetic resonance angiography (MRA) of the lower limb arteries using three-dimensional multishot T1-weighted fast-field echo-echo planar imaging (3D multishot T1-FFE-EPI), and it was optimized the protocol. The image distortion for the change in the EPI factor was calculated using 3.0 T-MRI and MRI phantom. We also calculated the signal-to-noise ratio (SNR) of the femoral artery with a change in the flip angle on images of 8 healthy volunteers. Furthermore, the optimal EPI factor was determined from the SNR of the femoral artery and the contrast ratio between the femoral artery and the adductor magnus. Two radiological technologists performed a retrospective visual assessment of the pelvis, thigh, and leg of 10 patients who underwent lower limb non-contrast-enhanced MRA and contrast-enhanced tomography angiography (CTA). The optimum flip angle and EPI factor were 25° and 3, respectively. In the visual assessment of clinical cases, there was no significant difference between the non-contrast-enhanced MRA and contrast-enhanced CTA in the pelvis and the leg (p=0.52 and p=0.88, respectively). In the thigh, non-contrast-enhanced MRA was significantly higher (p=0.02), namely, the ability to visualize the lower limb arteries was not much difference between this method and contrast-enhanced CTA. Our method without electrocardiogram gated and contrast medium is expected for screening tests or detailed examinations.

High spatial resolution MRA of renal arteries using contrast behavior between fat and water during transient phase before reaching a steady state.

PURPOSE: Our aim is high spatial resolution imaging of maximum intensity projection (MIP) images in renal magnetic resonance angiography (MRA) by constructing a protocol for acquiring three-dimensional volume data with isotropic voxels. MATERIALS AND METHODS: We eliminated water-selective excitation (WATS) and utilized effective contrast behavior between fat and water before reaching a steady state-that is, during the transient phase-to cover fat suppression by WATS. In a phantom study, the optimal flip angle was investigated under the "low-high Y" profile order using distilled water and baby oil to construct a protocol with isotropic voxels. Signal intensity, contrast, noise and signal-to-noise ratio were investigated to compare image qualities between the conventional and the constructed isotropic protocols. In a clinical study, three radiologists and two radiological technologists visually evaluated clinical images of 20 volunteers for spatial resolution, contrast and overall reader confidence in two protocols. RESULTS: We constructed an isotropic protocol with voxel dimensions of 0.78 mm × 0.78 mm × 0.78 mm at a flip angle of 90°. We maintained the scan time but enlarged the x-y pixel dimensions from 0.59 mm × 0.59 mm to 0.78 mm × 0.78 mm and shortened image height from 48 mm to 42.9 mm. Data from the phantom study were worse in the isotropic protocol than in the conventional protocol. However, overall reader confidence in the clinical images was significantly better in the isotropic protocol than in the conventional protocol (p<.001). CONCLUSION: Our study indicated the value of addressing high spatial resolution imaging of MIP images for renal MRA by constructing an isotropic protocol.