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Numerous studies have reported conflicting results associated with cow's milk intake and coronary heart disease (CHD). However, studies involving postmenopausal women are very limited. This study was therefore undertaken to identify the relationship between cow's milk intake and CHD risk in postmenopausal women, using data from the 6th period of the Korea National Health and Nutrition Examination Survey (2013−2015). A total of 1825 postmenopausal women, aged 50−64 years old, were included in the final analysis. The frequency of cow's milk consumption for each subject was determined using the semi-quantitative food frequency questionnaire, and was classified into four groups (Q1−Q4): Q1, group that did not drink milk (no milk, n = 666); Q2, 0 < frequency of milk intake per week ≤ 1 (n = 453); Q3, 1 < frequency of milk intake per week ≤ 3 (n = 319); and Q4, frequency of milk intake >3 times per week (n = 387). General characteristics, such as education, living area, household income, and obesity level, were compared between the four groups. Percentages of daily nutrient intake compared to the dietary reference intake for Koreans (KDRIs) were determined, and the Framingham Risk Score (FRS), atherogenic index (AI), and atherogenic index of plasma (AIP) were determined as the CHD risk indicators. Except household income, no significant difference was obtained among the four groups with respect to age, education, living area, or obesity. Compared to KDRIs, the intake ratio of calcium, phosphorus, and riboflavin were significantly higher in the Q4 group than in the Q1−Q3 groups. Blood HDL-cholesterol was significantly higher in Q4 than in Q1. The CHD risk factors FRS (%), AI, and AIP were significantly lower in the Q4 group as compared to the other groups (CHD risk (%): Q1 9.4, Q4 8.5; AI: Q1 3.06, Q4 2.83; API: Q1 0.37, Q2 0.31, Q4 0.32). FRS was determined to be significantly and positively correlated to AI or AIP, and negatively correlated with the cow's milk intake frequency and calcium intake. In conclusion, compared to women who do not consume cow's milk, postmenopausal women who consume cow's milk frequently have a better nutritional status of calcium, phosphorus, and vitamin B12, higher HDL levels, and a lower level of CHD risk indicators, such as FRS, AI, and AIP, contributing to decreased CHD risk in a 10-year period. Therefore, to prevent the risk of CHD in postmenopausal women, there needs to be a greater emphasis for cow's milk consumption four or more times per week.
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Enfermedad Coronaria , Leche , Animales , Bovinos , Enfermedad Coronaria/epidemiología , Enfermedad Coronaria/etiología , Enfermedad Coronaria/prevención & control , Femenino , Leche/efectos adversos , Encuestas Nutricionales , Estado Nutricional , PosmenopausiaRESUMEN
BACKGROUND: Dry eye disease (DED) cannot be diagnosed by a single test because it is a multifactorial disorder of the ocular surface. Although studies on various dry eye tests (DETs) in dogs have been reported, standard criteria have not been established except for the Schirmer tear test 1 (STT-1). OBJECTIVES: To establish reference values for DETs in dogs with normal STT-1 values (≥ 15 mm/min) and to analyze the correlation between DETs. METHODS: The STT-1 was performed in 10 healthy Beagle dogs (20 eyes). After 20 min, interferometry (IF) for estimating the lipid layer thickness (LLT) of the tear film, tear meniscus height (TMH), non-invasive tear breakup time (NIBUT), and meibomian gland loss rate of the upper eyelid (MGLRU) and lower eyelid (MGLRL), were measured using an ocular surface analyzer. RESULTS: Mean values for STT-1, TMH, and NIBUT were as follows: 21.7 ± 3.4 mm/min, 0.41 ± 0.21 mm, and 19.1 ± 9.5 sec, respectively. The most frequent LLT range, measured by IF, was 30-80 nm (11 eyes), followed by 80 nm (5 eyes) and 80-140 nm (4 eyes). MGLRU ≤ 25% was measured in 11 eyes and 26%-50% in 9 eyes; MGLRL ≤ 25% in 8 eyes and 26%-50% in 12 eyes. Besides positive correlation between TMH and NIBUT (P = 0.038), there were no significant associations between DETs. CONCLUSIONS: Data obtained in this study provided normative references that could be useful for diagnosing DED and for further research into correlation between DETs in dogs with DED.
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Enfermedades de los Perros , Síndromes de Ojo Seco , Animales , Enfermedades de los Perros/diagnóstico , Perros , Síndromes de Ojo Seco/diagnóstico , Síndromes de Ojo Seco/veterinaria , Lípidos , Glándulas Tarsales , Proyectos Piloto , Valores de Referencia , LágrimasRESUMEN
BACKGROUND: To assess the normal retina of the pigeon eye using spectral domain optical coherence tomography (SD-OCT) and establish a normative reference. METHODS: Twelve eyes of six ophthalmologically normal pigeons (Columba livia) were included. SD-OCT images were taken with dilated pupils under sedation. Four meridians, including the fovea, optic disc, red field, and yellow field, were obtained in each eye. The layers, including full thickness (FT), ganglion cell complex (GCC), thickness from the retinal pigmented epithelium to the outer nuclear layer (RPE-ONL), and from the retinal pigmented epithelium to the inner nuclear layer (RPE-INL), were manually measured. RESULTS: The average FT values were significantly different among the four meridians (p < 0.05), with the optic disc meridian being the thickest (294.0 ± 13.9 µm). The average GCC was thickest in the optic disc (105.3 ± 27.1 µm) and thinnest in the fovea meridian (42.8 ± 15.3 µm). The average RPE-INL of the fovea meridian (165.5 ± 18.3 µm) was significantly thicker than that of the other meridians (p < 0.05). The average RPE-ONL of the fovea, optic disc, yellow field, and red field were 91.2 ± 5.2 µm, 87.7 ± 5.3 µm, 87.6 ± 6.5 µm, and 91.4 ± 3.9 µm, respectively. RPE-INL and RPE-ONL thickness of the red field meridian did not change significantly with measurement location (p > 0.05). CONCLUSIONS: Measured data could be used as normative references for diagnosing pigeon retinopathies and further research on avian fundus structure.
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Columbidae/anatomía & histología , Retina/anatomía & histología , Tomografía de Coherencia Óptica/veterinaria , Animales , Columbidae/fisiología , Valores de Referencia , Retina/fisiología , Epitelio Pigmentado de la Retina/anatomía & histología , Epitelio Pigmentado de la Retina/fisiologíaRESUMEN
A number of research attempts to understand and modulate sensory and motor skills that are beyond the capability of humans have been underway. They have mainly been expounded in rodent models, where numerous reports of controlling movement to reach target locations by brain stimulation have been achieved. However, in the case of birds, although basic research on movement control has been conducted, the brain nuclei that are triggering these movements have yet to be established. In order to fully control flight navigation in birds, the basic central nervous system involved in flight behavior should be understood comprehensively, and functional maps of the birds' brains to study the possibility of flight control need to be clarified. Here, we established a stable stereotactic surgery to implant multi-wire electrode arrays and electrically stimulated several nuclei of the pigeon's brain. A multi-channel electrode array and a wireless stimulation system were implanted in thirteen pigeons. The pigeons' flight trajectories on electrical stimulation of the cerebral nuclei were monitored and analyzed by a 3D motion tracking program to evaluate the behavioral change, and the exact stimulation site in the brain was confirmed by the postmortem histological examination. Among them, five pigeons were able to induce right and left body turns by stimulating the nuclei of the tractus occipito-mesencephalicus (OM), nucleus taeniae (TN), or nucleus rotundus (RT); the nuclei of tractus septo-mesencephalicus (TSM) or archistriatum ventrale (AV) were stimulated to induce flight aviation for flapping and take-off with five pigeons.
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This study aimed to investigate the effect of mydriasis using topical rocuronium bromide on electroretinography (ERG) in domestic pigeons (Columba livia). Scotopic mixed rod and cone, photopic cone, and photopic flicker ERG were performed on nine eyes of nine healthy adult pigeons under sedation. Each pigeon underwent two sets of ERG recordings. First, without the induction of mydriasis (control) and the second time with the induction of mydriasis using topical rocuronium bromide (treatment). The results were compared using either the Student's t-test or Wilcoxon rank-sum test, where a P-value of <0.05 was considered statistically significant. No significant differences were observed in the a- and b-wave implicit times and amplitudes during scotopic ERG between the two groups. The a- and b-wave amplitudes in the photopic cone were significantly higher in the treatment group (63.83 ± 32.33 and 191.75 ± 94.46 µV) compared to the control group (46.15 ± 27.60 and 116.76 ± 70.65 µV; P=0.045 and P=0.032, respectively). The photopic flicker amplitude was also significantly higher in the treatment group (76.23 ± 48.56 µV) than in the control group (42.18 ± 31.18 µV; P=0.044). No statistically significant differences were observed in the photopic cone and flicker implicit times between both groups. In conclusions, mydriasis induced by rocuronium bromide in pigeon resulting in higher amplitudes during the photopic ERG but not scotopic ERG.
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Electrorretinografía , Midriasis , Animales , Columbidae , Midriasis/inducido químicamente , Midriasis/veterinaria , RocuronioRESUMEN
The array invariant technique has been recently proposed for passive source localization in the ocean. It has successfully estimated the source-receiver horizontal range in multipath-dominant shallow-water waveguides. However, it requires a relatively large-scale hydrophone array. This study proposes an array invariant method that uses acoustic intensity, which is a vector quantity that has the same direction as the sound wave propagating through a water medium. This method can be used to estimate not only the source-receiver horizontal range, but also the azimuth to an acoustic source. The feasibility of using a vector quantity for the array invariant method is examined through a simulation and an acoustic experiment in which particle velocity signals are obtained using a finite difference approximation of the pressure signals at two adjacent points. The source localization results estimated using acoustic intensity are compared with those obtained from beamforming of the acoustic signals acquired by the vertical line array.
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Animals digest food to fuel brain neurometabolism via cellular respiration. This study demonstrates the combination of a biofuel cell (BFC) and an animal brain stimulator (ABS) implanted in a pigeon. Glucose oxidation and oxygen reduction in an enzymatic BFC supplied electrical power to the ABS. Power from the BFC reached 0.12 mW in vitro and 0.08 mW in vivo using only the natural glucose and oxygen in the pigeon's body. A power management integrated circuit is used to harvest energy from the in vivo BFC at a rate of 28.4 mJ over 10 min, which is sufficient for intermittent neurostimulation.
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Fuentes de Energía Bioeléctrica , Técnicas Biosensibles , Animales , Aves , Encéfalo , Comunicación , Electrodos , Glucosa , OxígenoRESUMEN
OBJECTIVE: To evaluate the clinical relevance of intraocular pressure (IOP) measured with three different rebound tonometers in an ex vivo analysis and clinical trials in dogs. ANIMALS AND PROCEDURES: Ex vivo analysis and clinical trials were performed separately. For the ex vivo analysis, eight enucleated eyes were obtained from four Beagle dogs. IOP values measured with TONOVET® (TV-IOP), TONOVET-Plus® (TVP-IOP), and SW-500® (SW-IOP) were compared with manometric IOPs. For clinical trials, each tonometer was evaluated separately, depending on whether TVP-IOP was higher or lower than 14 mm Hg. One-way repeatedmeasures analysis of variance, simple linear regression analysis, and Bland-Altman plots were used for statistical analyses. RESULTS: In ex vivo analysis, TV-IOP and TVP-IOP were not significantly different from manometric IOP. However, SW-IOP underestimated IOP compared to manometry. Higher discrepancy was observed in TV-IOP and SW-IOP with an increase in manometric IOP. In clinical trials, no significant difference was observed between TV-IOP (9.73 ± 2.92) and TVP-IOP (11.36 ± 2.23) when TVP-IOP was lower than 14 mm Hg, but SW-IOP (8.70 ± 3.03) was significantly lower than TVP-IOP. TV-IOP (15.96 ± 6.47) and SW-IOP (13.09 ± 3.72) were significantly lower than TVP-IOP (20.08 ± 6.60) when the IOP was higher than 14 mm Hg of TVP-IOP. CONCLUSIONS: This study demonstrates that the TONOVET® and TONOVET-Plus® provide a useful approach for ex vivo analysis. In clinical trials, results of TV-IOP and SW-IOP were significantly lower than of TVP-IOP when IOP was higher than 14 mm Hg of TVP-IOP. The characteristics of rebound tonometers should be considered in clinical settings.
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Presión Intraocular , Tonometría Ocular/veterinaria , Animales , Perros , Técnicas In Vitro , Tonometría Ocular/instrumentación , Tonometría Ocular/métodosRESUMEN
OBJECTIVE: The authors' goal was to study avian motor brain mapping via wireless stimulation to induce certain behaviors. In this paper, the authors propose an electrode design that is suitable for avian brain stimulation as well as a stereotactic implant procedure for the proposed electrode. METHODS: An appropriate breed for avian brain study was chosen. A fully implantable remote-controlled electrical stimulation system was inserted to minimize discomfort. A suitable electrode design and stereotactic surgery method based on the electrode design were investigated. RESULTS: Using a wireless stimulation system, flapping and rotation behaviors were induced by stimulating the ventral part of the nucleus intercollicularis and formatio reticularis medialis mesencephali both on the ground and during flight. CONCLUSIONS: The authors were able to implant the entire brain stimulation system inside the avian body without any surgical complications. Postoperative observations suggested that the bird did not find the implant uncomfortable.
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Encéfalo/fisiología , Encéfalo/cirugía , Estimulación Encefálica Profunda , Técnicas Estereotáxicas , Animales , Aves , Mapeo Encefálico/métodos , Estimulación Encefálica Profunda/métodos , Estimulación Eléctrica/métodos , Electrodos Implantados , Humanos , Imagenología TridimensionalRESUMEN
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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BACKGROUND: Animal learning based on brain stimulation is an application in a brain-computer interface. Especially for birds, such a stimulation system should be sufficiently light without interfering with movements of wings. OBJECTIVE: We proposed a fully-implantable system for wirelessly navigating a pigeon. In this paper, we report a handheld neural stimulation controller for this avian navigation guided by remote control. METHODS: The handheld controller employs ZigBee to control pigeon's behaviors through brain stimulation. ZigBee can manipulate brain stimulation remotely while powered by batteries. Additionally, simple switches enable users to customize parameters of stimuli like a gamepad. These handheld and user-friendly interfaces make it easy to use the controller while a pigeon flies in open areas. RESULTS: An electrode was inserted into a nucleus (formatio reticularis medialis mesencephalic) of a pigeon and connected to a stimulator fully-implanted in the pigeon's back. Receiving signals sent from the controller, the stimulator supplied biphasic pulses with a duration of 0.080 ms and an amplitude of 0.400 mA to the nucleus. When the nucleus was stimulated, a 180-degree turning-left behavior of the pigeon was consistently observed. CONCLUSIONS: The feasibility of remote avian navigation using the controller was successfully verified.
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Computadoras de Mano , Electrodos Implantados/veterinaria , Vuelo Animal/fisiología , Orientación Espacial/fisiología , Tecnología Inalámbrica/instrumentación , Animales , Interfaces Cerebro-Computador , Columbidae/fisiología , Suministros de Energía Eléctrica , Estimulación Eléctrica , Electrodos , Diseño de Equipo , Estudios de Factibilidad , Sistemas de Información Geográfica/instrumentación , Tecnología de Sensores Remotos/instrumentación , Tecnología de Sensores Remotos/veterinaria , Robótica/instrumentación , Robótica/métodos , Navegación Espacial/fisiologíaRESUMEN
The purpose of this study was to develop effective dental hygiene chews for cats based on the anatomical features of the dentition and patterns of chewing motion. All cats were volunteered for dental prophylaxis followed by dental impressions using yellow stone and alginate under general anesthesia. Twenty parameters related to dentition were defined in order to compare dental impressions using digital caliper. For the chewing motion study, patterns of chewing motion were identified based on recordings made with a digital camera. Ten cats (4 domestic shorthairs, 2 Russian blues, 1 American shorthair, 1 Persian, 1 Turkish Angora, and 1 Devon Rex) were recruited for the study. The parameters related to teeth and oral size were similar among the studied cats. Chewing motion can be described as more of a guillotine-like motion rather than a crushing motion, with cats chewing 3-7 times before swallowing. The chewing pattern of cats involves shearing for a short period of time followed by immediate swallowing. Therefore, the overall size of the dental hygiene chew could be determined based on the measurement of the oral size for inducing chewing. The surface details of the dental hygiene chew could be designed for prevention and removal of dental calculus and plaque in cats considering the anatomical teeth parameters. Dental hygiene chews customized for cats considering the different anatomical features of their teeth might be effective for oral care.
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Goma de Mascar/análisis , Placa Dental/veterinaria , Higiene Bucal/veterinaria , Animales , Gatos , Placa Dental/tratamiento farmacológico , Dentición , Higiene Bucal/métodosRESUMEN
Transcriptional factor EB (TFEB) and nuclear factor E2-related factor 2 (Nrf2) play crucial roles in the biological response against cellular stressors; however, their relationship has not yet been investigated. Here, we constructed human neuroglioma cell lines stably expressing TFEB. The expression of Nrf2-response genes, including heme oxygenase (HO)-1, glutathione-s-transferase-mu1 (GSTM1), and p62, was induced in the cell line, independent of oxidative stress. Of note, the protein level of Nrf2 was significantly increased, and its ubiquitinated fraction was reduced in stable cells compared to that in the control cells. Among E3 ubiquitin ligases known to be involved in the ubiquitination of Nrf2, DDB1 and Cullin4 associated factor 11 (DCAF11) was down-regulated at both protein and mRNA levels in stable cells, indicating that the repression of DCAF11 by TFEB may be mainly involved in the stabilization of Nrf2. In addition, the level of phosphorylated p62 at S349 was highly increased in stable cells compared to that in control cells, which could allow it to interfere with the association of Keap1 and Nrf2, thus stabilizing Nrf2. We suggest for the first time that TFEB could activate Nrf2 by increasing its stability under conditions devoid of oxidative stress.
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Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/metabolismo , Factor 2 Relacionado con NF-E2/metabolismo , Complejos de Ubiquitina-Proteína Ligasa/genética , Línea Celular Tumoral , Regulación hacia Abajo , Células HEK293 , Humanos , Fosforilación/genética , Estabilidad Proteica , Proteínas de Unión al ARN/metabolismo , Complejos de Ubiquitina-Proteína Ligasa/metabolismo , UbiquitinaciónRESUMEN
Underwater acoustic sensor networks have recently attracted considerable attention as demands on the Internet of Underwater Things (IoUT) increase. In terms of efficiency, it is important to achieve the maximum communication coverage using a limited number of sensor nodes while maintaining communication connectivity. In 2017, Kim and Choi proposed a new deployment algorithm using the communication performance surface, which is a geospatial information map representing the underwater acoustic communication performance of a targeted underwater area. In that work, each sensor node was a vertically separated hydrophone array, which measures acoustic pressure (a scalar quantity). Although an array receiver is an effective system to eliminate inter-symbol interference caused by multipath channel impulse responses in underwater communication environments, a large-scale receiver system degrades the spatial efficiency. In this paper, single-vector sensors measuring the particle velocity are used as underwater sensor nodes. A single-vector sensor can be considered to be a single-input multiple-output communication system because it measures the three directional components of particle velocity. Our simulation results show that the optimal deployment obtained using single-vector sensor nodes is more effective than that obtained using a hydrophone (three-channel vertical-pressure sensor) array.
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This study was conducted to compare the effects of 3 different sedative agents on electroretinography (ERG) in domestic pigeons (Columba livia). Six pigeons were sedated with alfaxalone, xylazine, and medetomidine at separate times with a 1-week washout period between sedative administration. After sedation with each agent, pigeons underwent the modified ERG protocol adapted from the standardized protocol for dogs. The scotopic mixed rod and cone response was recorded after 20 minutes of dark adaptation, and the photopic cone response and photopic flicker response were recorded after 10 minutes of light adaptation. Either a 1-way analysis of variance or a Kruskall-Wallis test was used to compare the a-wave and b-wave implicit time and amplitude. No significant differences were observed in the scotopic mixed rod and cone response among all 3 sedatives used. Compared with alfaxalone, medetomidine significantly prolonged the a-wave implicit time, depressed the b-wave amplitude of photopic cone response, and prolonged the peak implicit time of the photopic flicker response (P < .05). These results show that medetomidine has a depressant effect on photopic ERG in pigeons at a dosage that produces light sedation.
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Columbidae , Electrorretinografía/veterinaria , Medetomidina/farmacología , Pregnanodionas/farmacología , Xilazina/farmacología , Anestésicos/farmacología , Animales , Estudios Cruzados , Hipnóticos y Sedantes/farmacologíaRESUMEN
The olfactory bulb (OB) shows special characteristics in its phylogenetic cortical structure and synaptic pattern. In the OB, gamma-aminobutyric acid (GABA), as an inhibitory neurotransmitter, is secreted from GABAergic neurons which contain parvalbumin (a calcium-binding protein). Many studies on the distribution of parvalbumin-immunoreactive neurons in the rodent OB have been published but poorly reported in the avian OB. Therefore, in this study, we compared the structure of the OB and distribution of parvalbumin-immunoreactive neurons in the OB between the rat and pigeon using cresyl violet staining and immunohistochemistry for parvalbumin, respectively. Fundamentally, the pigeon OB showed layers like those of the rat OB; however, some layers were not clear like in the rat OB. Parvalbumin-immunoreactive neurons in the pigeon OB were predominantly distributed in the external plexiform layer like that in the rat OB; however, the neurons did not have long processes like those in the rat. Furthermore, parvalbumin-immunoreactive fibres were abundant in some layers; this finding was not shown in the rat OB. In brief, parvalbumin-immunoreactive neurons were found like those in the rat OB; however, parvalbumin-immunoreactive fibres were significantly abundant in the pigeon OB compared to those in the rat OB.
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Columbidae/anatomía & histología , Bulbo Olfatorio/citología , Parvalbúminas/análisis , Ratas Sprague-Dawley/anatomía & histología , Animales , Benzoxazinas , Colorantes , Columbidae/metabolismo , Inmunohistoquímica/veterinaria , Masculino , Bulbo Olfatorio/química , Parvalbúminas/inmunología , Ratas , Ratas Sprague-Dawley/metabolismo , Coloración y Etiquetado/veterinariaRESUMEN
This study examined the dietary nutrient intake of Korean adolescent distance runners and analyzed the difference between weekdays and weekends. The participants were 40 male middle- and long-distance runners aged 13 to 18 years, 36 of whom were analyzed. The 3-day diet records including 2 weekdays and 1 weekend day, were investigated according to the food record method and analyzed using the computer-aided nutritional analysis program. A paired t-test was used to compare the energy and nutrient intakes of the weekdays and weekends, and the chi-square test was used to compare the distribution of the nutrient intake below the estimated average requirement. The results showed that the energy intake per day was quite low at 2,051.0±304.3 kcal, with a body mass index percentile of 16.8±9.8. The nutrients that showed remarkably lower levels than the dietary reference intakes for Koreans were vitamin D, vitamin C, vitamin B2, and calcium, among which calcium was the highest at 86.1% in the proportion of those who consumed less than the estimated average requirement. The intakes of vitamin C and calcium, in particular, showed a significant decrease during the weekends. Therefore, to improve the dietary nutrient intake of adolescent male runners, appropriate management of the weekend diet as well as school meals should be considered.
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Navigation of freely moving animals has been studied for potential application to emergency situations and hazardous environments. A fully implantable stimulation system for remote animal navigation was proposed and applied to living pigeons. The animal navigation system, consisting of an external controller and a neural stimulator, was designed based on the anatomy of the pigeons. Depth electrodes were fabricated based on the anatomy of target pigeon brain regions. The fabricated neural stimulators received data wirelessly from the external controller and generated biphasic current pulses with preset parameters of amplitude, duration, and rate. The average impedance of the fabricated electrodes was 12.0â -13.05° kΩ at 1 kHz. The neural stimulator was implanted on the dorsal side, and the depth electrodes were inserted into the formatio reticularis medialis mesencephali (FRM). When successive current pulses with an amplitude of 400 µA, a rate of 58 Hz, and a duration of 80 µs were applied to the target regions at 0.85 s intervals, turning/circling behaviors were induced for 6.2 s. The feasibility of the proposed wireless stimulation system was demonstrated in vivo.
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Columbidae , Estimulación Eléctrica , Electrodos Implantados , Tecnología Inalámbrica , Animales , Encéfalo , Impedancia EléctricaRESUMEN
This paper describes the electrical modulation of locomotion in pigeons using deep brain electrodes. Polymer-based depth electrodes with four channels were fabricated. Based on the location of the nucleus intercollicularis (ICo), the shanks of the depth electrodes were designed to be a length of 11 mm. After the implantation of the depth electrode into the ICo region of the brain, it was connected by wires to a custom-made stimulator, and biphasic current pulses were delivered. Current pulses with an amplitude of 0.5 mA, a rate of 58.0 Hz, and a duration of $320\mu \mathrm{s} $s were applied for 0.5 s. When the ICo region was electrically stimulated, taking-off behavior was successfully induced for 0.4 s. Induction of taking-off behavior by electrical stimulation, when coupled to control of turning and running forward locomotions, may contribute to the development of remote flight-control system of freely moving pigeon.