[Effectiveness of cerebrolysin in hypertensive supratentorial intracranial hemorrhages: results of a randomized triple blind placebo-controled study].

Cerebrolysin was administered to 38 patients with small hypertensive supratentorial intracranial hemorrhages. Cerebrolysin was used intravenous in drops in dosage of 30 ml during 14 days. High effectiveness and good tolerability of the treatment was shown. In the end of treatment, groups receiving cerebrolysin or placebo were statistically significant differed by the total NIHSS score, Bartel index and the Rankin's modified scale. Moreover, a trend to the decrease of intracranial hemorrhage volume was observed in patients treated with cerebrolysin.

[Diagnosis of sarcoidosis of the brain].

Based on 15 years' their own experience and clinical observations of 65 patients with sarcoidosis of the brain, the authors have formulated diagnostic algorithms and a battery of studies that can suspect this disease. Since the clinical manifestations of sarcoidosis of the brain are non-specific, particularly at the early stages of its development, the condition of its recognition is the application of all required high-informative diagnostic neuroimaging techniques that are available to a neurological clinic. Nevertheless, sarcoidosis cannot be timely and correctly recognized in all cases. Diagnostic errors in its recognition are caused by the fact that X-ray computed tomography and/or magnetic resonance imaging is untimely made, tomographic changes are erroneously interpreted, and the studies are conducted improperly.

[The dynamics of lipid peroxidation in patients with acute disorders of the cerebral circulation of an ischemic nature]. / Dinamika perekisnogo okisleniia lipidov u bol'nykh s ostrymi narusheniiami mozgovogo krovoobrashcheniia ishemicheskogo kharaktera.

Lipid peroxidation (LP) was analysed in the blood and atherogenic lipoproteins of 36 patients with ischemic stroke in the internal carotid arteries at the acute stage (1, 7 and 21 days). During 1-7 days 22 patients (group 1) were treated with haemocorrecting drugs (rheopolyglucin, euphyllin, aspirin, curantyl, trental) and 14 patients (group 2) were treated with vasoactive and metabolic drugs (cavinton, complamin, actovegin). On days 8-21 all the patients received the same treatment: pyracetam and essential. Before the treatment both activation of LP and exhaustion of endogenic antioxidant background were observed in blood samples of all the patients. Significant changes of LP parameters were observed in group 1 up to day 7, but they reached the basic level on the 21 day. No significant changes were observed in group 2. Thus, haemocorrecting drugs had some antioxidant effects, but to provide a steady antioxidant effect it is necessary to use special antioxidants.

[Cerebral sarcoidosis diagnosed by biopsy]. / Tserebral'nyi sarkoidoz, diagnostirovannyi s pomoshch'iu biopsii.

Space-occupying lesion was found by head computer tomography in the left brain hemisphere of the patients with lung and lymph node sarcoidosis. Neurologic symptoms and clinical course did not allow to exclude brain tumour. Granulomas typical for sarcoidosis were found in the stereotaxis biopsy of the parietal brain region.

[Clinical course of the initial manifestations of cerebrovascular insufficiency in arterial hypertension]. / Klinicheskoe techenie nachal'nykh proiavlenii nedostatochnosti krovosnabzheniia mozga pri arterial'noi gipertonii.

A study was made of the catamnesis of 96 patients with the initial manifestations of brain blood supply insufficiency. After the first examination under inpatient conditions the patients were followed up for up to 7 years on the average. During the observation period, 56 patients demonstrated an increase of cerebral complaints and their enhancement as regards the intensity. It should be noted that the patients' age did not produce any influence on the increment of cerebral complaints. During the same observation period, 49% of the patients manifest different acute disorders of cerebral circulation. Despite the apparent relatively mild and reversible clinical signs, the initial manifestations of brain blood supply insufficiency should be viewed as progressive vascular diseases of the brain. Taking into account the data obtained, it is advisable that this patients' group is to be followed up with a purpose of carrying out the treatment and prophylactic measures.