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Drug Discov Today ; 22(6): 896-911, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-28412474

RESUMEN

A considerable number of approved drugs show non-equilibrium binding characteristics, emphasizing the potential role of drug residence times for in vivo efficacy. Therefore, a detailed understanding of the kinetics of association and dissociation of a target-ligand complex might provide crucial insight into the molecular mechanism-of-action of a compound. This deeper understanding will help to improve decision making in drug discovery, thus leading to a better selection of interesting compounds to be profiled further. In this review, we highlight the contributions of the Kinetics for Drug Discovery (K4DD) Consortium, which targets major open questions related to binding kinetics in an industry-driven public-private partnership.


Asunto(s)
Descubrimiento de Drogas , Preparaciones Farmacéuticas/metabolismo , Animales , Industria Farmacéutica , Humanos , Cinética , Farmacocinética
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