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Epilepsy Behav ; 71(Pt B): 130-141, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-26228091

RESUMEN

The more recent history and main experimental data for the Krushinsky-Molodkina (KM) audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain is inbred, and two new strains are maintained in a laboratory in parallel. These strains originated from KM×Wistar hybrids and were bred (starting from 2000) for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogenic seizure physiology were accumulated in parallel with (and usually ahead of) data on other audiogenic-prone strains. The peculiar feature of the KM strain is its vulnerability to brain hemorrhages. Thus, the KM strain is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".


Asunto(s)
Estimulación Acústica/efectos adversos , Epilepsia Refleja/genética , Epilepsia Refleja/fisiopatología , Estimulación Acústica/métodos , Animales , Encéfalo/fisiopatología , Humanos , Fenotipo , Ratas , Ratas Wistar , Convulsiones/genética , Convulsiones/fisiopatología , Especificidad de la Especie , Factores de Tiempo
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