Converter gas is a large scale waste product that is usually burned to carbon dioxide and contributes to the world emission of greenhouse gases. Herein we demonstrate that instead of burning the converter gas can be used as a reducing agent in organic reactions to produce valuable pharmaceuticals and agrochemicals. In particular, amide-based selected drug molecules have been synthesized by a reaction of aromatic nitro compounds and carboxylic acids in the presence of converter gas. In addition, we showed that this gas can also be conveniently utilized to carryout classical reductive amination reaction.
A series of substituted pyridine dialcohols (2,6-bis(hydroxyalkyl)pyridines), 1-4, was used for the synthesis of various types of aluminum complexes. Aluminum methyl derivatives, 2-4a, were obtained by the reaction of AlMe3 with the corresponding ligand or transmetallation reactions of germylenes. Aluminum chloride complexes, 3-4b, were obtained by substitution of the Me group under the action of chlorinating agents. Methoxy-, 2-4c, or benzyloxy-, 2d, aluminum complexes were synthesized in transalkoxylation reaction of Me2Al(OX) (X = Me, Bn) by the corresponding ligand. All complexes obtained were thoroughly investigated by multinuclear NMR and X-ray analysis. It has been established that the structure of the ligand (number of carbon atoms) determines the nature of the complexes formed. Compounds were used as initiators of ring-opening polymerization of l-lactide and ε-caprolactone and showed moderate activity with controlled or immortal character.
The coordination polyhedron at the silicon atom in the title compound, C26H37Cl2NO2Si·0.25C7H8, is typical for penta-coordinated silicon derivatives and represents a slightly distorted trigonal bipyramid with an N atom and a Cl atom in the apical positions and the two O atoms and the other Cl atom occupying the equatorial sites. There are two independent mol-ecules in the asymmetric unit. The N-Si-Cl fragment in each is close to linear [178.24â (5) and 178.71â (5)°], in good agreement with 4e-3c theory, as is the elongation of the apical bond lengths [Si-Cl = 2.1663â (7) and 2.1797â (7)â Å] in comparison with the equatorial bonds [Si-Cl = 2.0784â (7) and 2.0748â (7)â Å]. Orthogonal least-squares fitting of the two independent mol-ecules resulted in r.m.s. deviation of 0.017â Å. The conformations of the two mol-ecules are almost the same, with corresponding torsion angles differing by less than 5.5°. The toluene solvent mol-ecule is disordered about an inversion centre.
In the title compound, [Al(C16H14N2O2)(C3H7O)]·0.5CH2Cl2, the salen complex is monomeric and the dichlormethane solvent mol-ecule lies on a crystallographic twofold axis. The central Al atom is fivefold coordinated and possesses a square-based pyramidal environment. The Al-OAlk( (i) prop-yl) bond [1.7404â (14)â Å] is much shorter than the Al-OAr(salen) bond lengths [1.7974â (15) and 1.8094â (14)â Å]. The iso-propyl-oxo group forms an intra-molecular C-Hâ¯N hydrogen bond. In the crystal, the complex mol-ecules are linked by weak C-Hâ¯O inter-actions.
