[Rapid determination of ceftriaxone in mixed saliva of practically healthy subjects and patients with infectious and somatic pathologies].

A method for spectroscopic determination of ceftriaxone in saliva of healthy subjects and patients with upper respiratory tract infections was developed. The concentration range is 1-50 mcg/ml. The method is express and simple, and can be used to determine ceftriaxone in clinical tests and pharmacokinetic studies. Possible determination of ceftriaxone in aqueous solutions was demonstrated which is useful in analysis of drugs.

[Spectrophotometric determination of cefazolin in mixed saliva of practically healthy subjects and patients with infective somatic pathology].

The behaviour of cefazolin in aqueous and biological media with varying the antibiotic concentration was studied by UV-spectroscopy. Range of the contents and the detection limits of cefazolin were determined. The procedure of UV-spectroscopy of cefazolin in mixed saliva of patients with urinary tract infection was developed.

Effect of terahertz electromagnetic irradiation at nitric oxide frequencies on concentration of nitrites in blood serum of albino rats under conditions of immobilization stress.

The terahertz electromagnetic irradiation at NO emission and absorption spectrum frequencies elevated the concentration of nitrites in blood serum of albino rats subjected to acute immobilization stress.

[Modern methods of antibiotic determination in biological samples and drugs (review)].

The analysis of the literature data for the last 10 years showed that microbiological, spectroscopic, chromatographic and electrochemical methods were most often used in quantitative determination of antibiotics in biological samples and drugs. Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones and other antibiotics were widely investigated. The characteristics of different methods of the antibiotic determination were discussed.

Separate detection of homologous surfactants by means of solid-contact unmodified and modified with molecular sieves potentiometric sensors.

To improve the selectivity of surfactant sensors, the surface of their membranes was modified with molecular sieves with predetermined pore sizes. Water-soluble anionic, cationic and non-ionic surfactants were used as pore generators in the molecular sieves and introduced into the source membrane at the stage of its formation. The modified sensors enable detection of alkylsulfates homologues and alkylpyridinium with different lengths of the hydrocarbon chain (C(10)-C(18)); homologous poly(oxyethylated nonylphenols) differing in the number of oxyethyl groups (m=10-100). A novel approach to separate detection of surfactant homologues implies the usage of inselective sensors as a multisensor system. The software-supported multisensor approach allows information of both mixture composition and concentrations of separate components in multicomponent systems to be obtained with a certain accuracy. Inselective non-modified sensors with the highest cross-sensitivity were used to design multisensor systems like an "electronic tongue". The cross-sensitivity parameters of both source and modified sensors were estimated and the possibility of their usage in multisensor systems like an "electronic tongue" for analysis of multicomponent solutions of homologous surfactant is shown. Analytical signals were processed by artificial neural networks.