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Curr Opin Struct Biol
; 65: 159-167, 2020 12.
Article
En
| MEDLINE
| ID: mdl-32739636
Allosteric regulation of the enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) controls the entry into aromatic amino acid biosynthesis in plants and microorganisms. DAH7PS has acquired a diverse range of allosteric machinery to enable this functionality. This review provides an overview of the current knowledge of the structural basis of allostery in this enzyme family and the evolutionary relationships between the different solutions to allosteric control of aromatic metabolite biosynthesis.
3-Deoxy-7-Phosphoheptulonate Synthase , Bacterial Proteins , Plant Proteins , 3-Deoxy-7-Phosphoheptulonate Synthase/chemistry , 3-Deoxy-7-Phosphoheptulonate Synthase/metabolism , Allosteric Regulation , Bacteria/enzymology , Bacterial Proteins/chemistry , Bacterial Proteins/metabolism , Plant Proteins/chemistry , Plant Proteins/metabolism , Plants/enzymology