Graft vs Host Disease , Hematopoietic Stem Cell Transplantation , Photopheresis , Recovery of Function/drug effects , Skin Diseases , Thymus Gland , Acute Disease , Allografts , Body Weight , Child, Preschool , Graft vs Host Disease/drug therapy , Graft vs Host Disease/physiopathology , Humans , Male , Skin Diseases/drug therapy , Skin Diseases/etiology , Skin Diseases/physiopathology
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology , Skin Neoplasms/pathology , Biopsy, Needle , Child, Preschool , Diagnosis, Differential , Follow-Up Studies , Humans , Immunohistochemistry , Male , Neoplasm Staging , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Risk Assessment , Scalp/pathology , Skin Neoplasms/diagnosis , Treatment Outcome
Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.
Anticonvulsants/adverse effects , Blister/etiology , Adolescent , Anticonvulsants/therapeutic use , Blister/chemically induced , Child , Edema/chemically induced , Epilepsy/drug therapy , Female , Humans , Male , Treatment Outcome
