Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Nat Neurosci ; 23(8): 981-991, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32514136

RESUMEN

Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level consequences of such reactivations remain unclear. Here, we imaged hundreds of neurons in visual association cortex across days as mice learned a visual discrimination task. Distinct patterns of neurons were activated by different visual cues. These same patterns were subsequently reactivated during quiet waking in darkness, with higher reactivation rates during early learning and for food-predicting versus neutral cues. Reactivations involving ensembles of neurons encoding both the food cue and the reward predicted strengthening of next-day functional connectivity of participating neurons, while the converse was observed for reactivations involving ensembles encoding only the food cue. We propose that task-relevant neurons strengthen while task-irrelevant neurons weaken their dialog with the network via participation in distinct flavors of reactivation.


Asunto(s)
Aprendizaje Discriminativo/fisiología , Plasticidad Neuronal/fisiología , Neuronas/fisiología , Corteza Visual/fisiología , Percepción Visual/fisiología , Animales , Señales (Psicología) , Alimentos , Privación de Alimentos/fisiología , Ratones , Recompensa
2.
J Neurosci ; 38(47): 10102-10113, 2018 11 21.
Artículo en Inglés | MEDLINE | ID: mdl-30282728

RESUMEN

In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan using a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin-expressing inhibitory interneurons toward a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.SIGNIFICANCE STATEMENT The study provides the first direct evidence of aggrecan as the main functional constituent and orchestrator of perineuronal nets (PNNs), and that loss of PNNs by aggrecan removal induces a permanent state of critical period-like plasticity. Loss of aggrecan ablates the PNN structure, resulting in invoked juvenile plasticity in the visual cortex and enhanced object recognition memory.


Asunto(s)
Agrecanos/deficiencia , Matriz Extracelular/metabolismo , Red Nerviosa/metabolismo , Plasticidad Neuronal/fisiología , Corteza Visual/metabolismo , Agrecanos/análisis , Agrecanos/genética , Animales , Línea Celular , Matriz Extracelular/química , Matriz Extracelular/genética , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Ratones Transgénicos , Red Nerviosa/química , Estimulación Luminosa/métodos , Corteza Visual/química
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA