The impact of the war on maintenance of long-term therapies in Ukraine.

Due to the Russian invasion, which started on 24 February 2022, the Ukrainian healthcare system is facing multiple challenges. A great number of healthcare facilities have been destroyed, while availability of other ones is often limited due to a lack of qualified medical staff. Certain services, e.g. cancer therapies, have been seriously disrupted. Moreover, millions of Ukrainians with chronic conditions are also suffering as due to war-related problems with execution of their long-term therapies. Availability of drugs is particularly limited in the occupied regions. According to the national statistics, as of 18 August 2022, about 505 pharmacies were damaged in Eastern Ukraine and 47 completely ruined. Moreover, the invaders have been blocking humanitarian aid provided to these territories by the Ukrainian government or other countries. Fortunately, in the areas controlled by the Government of Ukraine, the acute shortage of medicines, observed at the beginning of the war, has already been eliminated. Nevertheless, not all drugs are now fully available, even in the areas where no military attacks occur. The economic availability of drugs is also profoundly influenced by the significant increase in the cost of medications and the fall in average salaries. The Government of Ukraine is trying to minimise the impact of these war-related challenges by adopting a new legislation. This includes, among others, simplification of procedures for licensing, quality control and import of medicinal products to Ukraine. Other measures involve securing displaced people with the option of benefiting from local healthcare facilities, broadening the scope of the ePrescription system, authorizing primary care doctors to issue prescriptions to refugees, increasing the number of drugs reimbursed for long-term therapies, etc. These solutions, however, cannot balance all the harmful consequences the war in Ukraine brings in terms of maintenance of long-term therapies. Therefore, in order to minimise this negative impact, Ukraine still needs urgent international support in this area.

1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3-d]thiazoles as Potential Biologically Active Compounds.

A series of 11-substituted 3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones were obtained via hetero-Diels-Alder reaction of 5-alkyl/arylallylidene/-4-thioxo-2-thiazolidinones and 1,4-naphthoquinones. The structures of newly synthesized compounds were established by spectral data and a single-crystal X-ray diffraction analysis. According to U.S. NCI protocols, compounds 3.5 and 3.6 were screened for their anticancer activity; 11-Phenethyl-3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d]thiazole-2,5,10-trione (3.6) showed pronounced cytotoxic effect on leukemia (Jurkat, THP-1), epidermoid (KB3-1, KBC-1), and colon (HCT116wt, HCT116 p53-/-) cell lines. The cytotoxic action of 3.6 on p53-deficient colon carcinoma cells was two times weaker than on HCT116wt, and it may be an interesting feature of the mechanism action.

SELF-ESTEEM OF THE EATING BEHAVIOR BY THE STUDENT PHARMACEUTICAL YOUTH FROM THE VIEW OFTHE EXCESS BODY WEIGHT AND OBESITY.

OBJECTIVE: The aim: The purpose of the research is to study the understanding of student pharmaceutical youth the eating behavior in the context of the EBW and obesity. PATIENTS AND METHODS: Materials and methods: The material of the study was anonymous questionnaire survey the students of the pharmaceutical faculties from Ukraine. RESULTS: Results: The results of the questionnaire were analyzed using methods of statistics, comparison and generalization. Almost 9 out of 10 respondents from both universities consider the reason of obesity a sedentary lifestyle and poor nutrition, and the most effective way to treat it is physical activity, though only 36.3% and 28.4% of students of the corresponding samples have it constantly. CONCLUSION: Conclusions: The questionnaire showed a lack of eating behavior, of their knowledge of the basic issues of the EBW and obesity, as well as differences in personal perception and the desire for the practical implementation of queries regarding the weight of their body that may further affect the professional ability of young specialists in influencing the processes of formation and improving the quality of their lives and patients' lives.