1.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 31(2): 147-9, 2015 Mar.
Artículo
en Chino
| MEDLINE
| ID: mdl-26248422
2.
J Org Chem
; 75(9): 3125-8, 2010 May 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20394411
RESUMEN
A short and practical synthesis of oseltamivir was accomplished in 11 steps from inexpensive and abundant diethyl D-tartrate starting material. This azide-free route featured an asymmetric aza-Henry reaction and a domino nitro-Michael/Horner-Wadsworth-Emmons (HWE) reaction as the key steps to construct the relevant cyclohexene ring of the product, which provided an economical and practical alternative for the synthesis of oseltamivir.