Non-traumatic subarachnoid hemorrhage (SAH) is a critical neurosurgical emergency with a high mortality rate, imposing a significant burden on both society and families. Accurate prediction of the risk of death within 7 days in SAH patients can provide valuable information for clinicians, enabling them to make better-informed medical decisions. In this study, we developed six machine learning models using the MIMIC III database and data collected at our institution. These models include Logistic Regression (LR), AdaBoosting (AB), Multilayer Perceptron (MLP), Bagging (BAG), Gradient Boosting Machines (GBM), and Extreme Gradient Boosting (XGB). The primary objective was to identify predictors of death within 7 days in SAH patients admitted to intensive care units. We employed univariate and multivariate logistic regression as well as Pearson correlation analysis to screen the clinical variables of the patients. The initially screened variables were then incorporated into the machine learning models, and the performance of these models was evaluated. Furthermore, we compared the performance differences among the six models and found that the MLP model exhibited the highest performance with an AUC of 0.913. In this study, we conducted risk factor analysis using Shapley values to identify the factors associated with death within 7 days in patients with SAH. The risk factors we identified include Gcsmotor, bicarbonate, wbc, spo2, heartrate, age, nely, glucose, aniongap, GCS, rbc, sysbp, sodium, and gcseys. To provide clinicians with a useful tool for assessing the risk of death within 7 days in SAH patients, we developed a web calculator based on the MLP machine learning model.
Background: Intracerebral hemorrhage (ICH) is one of the most serious complications in patients with chronic kidney disease undergoing long-term hemodialysis. It has high mortality and disability rates and imposes a serious economic burden on the patient's family and society. An early prediction of ICH is essential for timely intervention and improving prognosis. This study aims to build an interpretable machine learning-based model to predict the risk of ICH in patients undergoing hemodialysis. Methods: The clinical data of 393 patients with end-stage kidney disease undergoing hemodialysis at three different centers between August 2014 and August 2022 were retrospectively analyzed. A total of 70% of the samples were randomly selected as the training set, and the remaining 30% were used as the validation set. Five machine learning (ML) algorithms, namely, support vector machine (SVM), extreme gradient boosting (XGB), complement Naïve Bayes (CNB), K-nearest neighbor (KNN), and logistic regression (LR), were used to develop a model to predict the risk of ICH in patients with uremia undergoing long-term hemodialysis. In addition, the area under the curve (AUC) values were evaluated to compare the performance of each algorithmic model. Global and individual interpretive analyses of the model were performed using importance ranking and Shapley additive explanations (SHAP) in the training set. Results: A total of 73 patients undergoing hemodialysis developed spontaneous ICH among the 393 patients included in the study. The AUC of SVM, CNB, KNN, LR, and XGB models in the validation dataset were 0.725 (95% CI: 0.610 ~ 0.841), 0.797 (95% CI: 0.690 ~ 0.905), 0.675 (95% CI: 0.560 ~ 0.789), 0.922 (95% CI: 0.862 ~ 0.981), and 0.979 (95% CI: 0.953 ~ 1.000), respectively. Therefore, the XGBoost model had the best performance among the five algorithms. SHAP analysis revealed that the levels of LDL, HDL, CRP, and HGB and pre-hemodialysis blood pressure were the most important factors. Conclusion: The XGB model developed in this study can efficiently predict the risk of a cerebral hemorrhage in patients with uremia undergoing long-term hemodialysis and can help clinicians to make more individualized and rational clinical decisions. ICH events in patients undergoing maintenance hemodialysis (MHD) are associated with serum LDL, HDL, CRP, HGB, and pre-hemodialysis SBP levels.
