Dual detection of Hg2+ and Pb2+ by a coumarin-functionalized Schiff base in environmental and biosystems.

Fluorescent chemosensors are often preferred for tracking toxic ions because of their non-destructive measurement and ease of use in environmental real samples and biosystems. Exploring high selectivity, great sensitivity, and biocompatible fluorophores with facile, accessible and dual-responsive features is currently highly demanding. A coumarin-based naphthol hydrazone Schiff base chemosensor, NaChro, is designed and synthesized in a two-step process to detect toxic metal ions with strong emission. Fluorescence spectra analysis demonstrates that the probe binds to Hg2+ and Pb2+ ions with a 1:1 and a 2:1 stoichiometry, respectively, with high sensitivity, short response time and minimal interference from other metal ions. The observed reversible turn-on reaction was attributed to the inhibition of C = N isomerization and excited-state intramolecular proton transfer (ESIPT) processes once the ions were introduced. The practical applications of NaChro are successfully addressed in paper strips, various water samples, HeLa cells and Zebrafish, demonstrating that the probe can detect and track Hg2+ and Pb2+ ions in environmental samples and biosystems.

Effects of tuning the structural symmetry of cobalt porphyrin on electrocatalytic oxygen reduction reactions.

Metalloporphyrins have attracted significant attention as highly promising alternatives to Pt-based electrocatalysts in the realm of oxygen reduction reactions (ORRs). While the structure of porphyrin is widely recognized as a pivotal factor influencing the ORR performance, the impact of molecular symmetry, which is one of the key properties of the molecular structure, has rarely been understood and its effects remain largely unexplored. Herein, we designed and synthesized two triphenylamine (TPA)-substituted cobalt porphyrins, the asymmetric aBz-TCoP and the symmetric Bz-2TCoP, which are doped onto carbon black to construct composite catalysts for ORRs. The electronic structures of both porphyrins are determined through density functional theory (DFT) calculations, and the morphology and electronic states of the composites are examined by spectroscopic techniques. A series of electrochemical measurements demonstrate the superior activity, selectivity and durability of Bz-2TCoP/C to aBz-TCoP/C in ORRs conducted in both acidic and alkaline electrolytes. The improved ORR properties of the symmetric porphyrin may stem from the steric properties rather than the electronic properties of the chemical structure. This work represents a preliminary study on the effects of porphyrin structural symmetry on electrocatalysis and provides a potential strategy for further structural modifications of metalloporphyrins, as non-noble metal electrocatalysts, to enhance the ORR performance.

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals.

Toxic cations, including heavy metals, pose significant environmental and health risks, necessitating the development of reliable detection methods. This review investigates the techniques and approaches used to strengthen the sensitivity and selectivity of Schiff base fluorescent chemosensors designed specifically to detect toxic and heavy metal cations. The paper explores a range of strategies, including functional group variations, structural modifications, and the integration of nanomaterials or auxiliary receptors, to amplify the efficiency of these chemosensors. By improving selectivity towards targeted cations and achieving heightened sensitivity and detection limits, consequently, these strategies contribute to the advancement of accurate and efficient detection methods while increasing the range of end-use applications. The findings discussed in this review offer valuable insights into the potential of leveraging Schiff base fluorescent chemosensors for the accurate and reliable detection and monitoring of heavy metal cations in various fields, including environmental monitoring, biomedical research, and industrial safety.

A pyridine modified naphthol hydrazone Schiff base chemosensor for Al3+ via intramolecular charge transfer process.

A pyridine modified naphthol hydrazone Schiff base chemosensor, NaPy, was prepared in a two-step process to detect aluminum ion (Al3+) in different samples. The probe shows a turn-off emission response towards Al3+ at a 1:1 binding stoichiometry via intramolecular charge transfer (ICT) mechanism, as validated by density functional theory (DFT) calculations and a series of spectroscopic measurements. The response time is slightly over one minute with a limit of detection (LOD) value of 0.164 µM, demonstrating the great sensitivity of the probe. It is also found that NaPy exhibits high selectivity towards Al3+ and resists interference from seventeen other cations. Application investigations in paper strips, water samples and HeLa cells suggest that NaPy can be used as an efficient probe for sensing Al3+ in real environmental samples and biosystems.