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1.
J Am Acad Dermatol ; 84(2): 432-470, 2021 Feb.
Article En | MEDLINE | ID: mdl-32738429

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the United States population. This guideline addresses important clinical questions that arise in psoriasis management and care and provides recommendations based on the available evidence. The treatment of psoriasis with topical agents and with alternative medicine will be reviewed, emphasizing treatment recommendations and the role of dermatologists in monitoring and educating patients regarding benefits as well as risks that may be associated. This guideline will also address the severity assessment methods of psoriasis in adults.


Complementary Therapies/methods , Dermatologic Agents/administration & dosage , Dermatology/methods , Psoriasis/therapy , Academies and Institutes/standards , Administration, Cutaneous , Combined Modality Therapy/methods , Combined Modality Therapy/standards , Complementary Therapies/standards , Dermatology/standards , Evidence-Based Medicine/methods , Evidence-Based Medicine/standards , Foundations/standards , Humans , Patient Education as Topic/standards , Psoriasis/diagnosis , Severity of Illness Index , Treatment Outcome , United States
2.
J Am Acad Dermatol ; 82(6): 1445-1486, 2020 Jun.
Article En | MEDLINE | ID: mdl-32119894

Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).


Psoriasis/drug therapy , Acitretin/therapeutic use , Cyclosporine/therapeutic use , Drug Monitoring , Humans , Methotrexate/therapeutic use , Piperidines/therapeutic use , Pyrimidines/therapeutic use , Thalidomide/analogs & derivatives , Thalidomide/therapeutic use
3.
J Am Acad Dermatol ; 82(1): 161-201, 2020 Jan.
Article En | MEDLINE | ID: mdl-31703821

Psoriasis is a chronic, multisystem, inflammatory disease that affects approximately 1% of children, with onset most common during adolescence. This guideline addresses important clinical questions that arise in psoriasis management and provides evidence-based recommendations. Attention will be given to pediatric patients with psoriasis, recognizing the unique physiology, pharmacokinetics, and patient-parent-provider interactions of patients younger than 18 years old. The topics reviewed here mirror those discussed in the adult guideline sections, excluding those topics that are irrelevant to, or lack sufficient information for, pediatric patients.


Biological Products/therapeutic use , Dermatologic Agents/therapeutic use , Methotrexate/therapeutic use , Photochemotherapy , Psoriasis/drug therapy , Psoriasis/epidemiology , Adolescent , Adrenal Cortex Hormones/therapeutic use , Anthralin/therapeutic use , Calcineurin Inhibitors/therapeutic use , Cardiovascular Diseases/epidemiology , Child , Child, Preschool , Coal Tar/therapeutic use , Comorbidity , Cyclosporine/therapeutic use , Dyslipidemias/epidemiology , Evidence-Based Medicine , Humans , Infant , Infant, Newborn , Inflammatory Bowel Diseases/epidemiology , Insulin Resistance , Mental Health , Metabolic Syndrome/epidemiology , Nicotinic Acids/therapeutic use , Obesity/epidemiology , Psoriasis/psychology , Retinoids/therapeutic use
4.
J Am Acad Dermatol ; 81(3): 775-804, 2019 Sep.
Article En | MEDLINE | ID: mdl-31351884

Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 3.2% of the world's population. In this section of the guidelines of care for psoriasis, we will focus the discussion on ultraviolet (UV) light-based therapies, which include narrowband and broadband UVB, UVA in conjunction with photosensitizing agents, targeted UVB treatments such as with an excimer laser, and several other modalities and variations of these core phototherapies, including newer applications of pulsed dye lasers, intense pulse light, and light-emitting electrodes. We will provide an in-depth, evidence-based discussion of efficacy and safety for each treatment modality and provide recommendations and guidance for the use of these therapies alone or in conjunction with other topical and/or systemic psoriasis treatments.


Dermatology/standards , Phototherapy/standards , Practice Guidelines as Topic , Psoriasis/therapy , Academies and Institutes/standards , Foundations/standards , Humans , Meta-Analysis as Topic , Phototherapy/instrumentation , Phototherapy/methods , Systematic Reviews as Topic , Treatment Outcome , United States
5.
J Am Acad Dermatol ; 80(4): 1073-1113, 2019 Apr.
Article En | MEDLINE | ID: mdl-30772097
6.
J Am Acad Dermatol ; 80(4): 1029-1072, 2019 Apr.
Article En | MEDLINE | ID: mdl-30772098

Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evidence. The treatment of psoriasis with biologic agents will be reviewed, emphasizing treatment recommendations and the role of the dermatologist in monitoring and educating patients regarding benefits as well as associated risks.


Biological Products/therapeutic use , Dermatologic Agents/therapeutic use , Psoriasis/drug therapy , Adalimumab/therapeutic use , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Biosimilar Pharmaceuticals/therapeutic use , Certolizumab Pegol/therapeutic use , Drug Therapy, Combination , Etanercept/therapeutic use , Evidence-Based Medicine , Humans , Infliximab/therapeutic use , Piperidines/therapeutic use , Pyrimidines/therapeutic use , Pyrroles/therapeutic use , Ustekinumab/therapeutic use
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