RESUMEN
We developed new miniature ring array transducers integrated into interventional device catheters such as used to deploy atrial septal occluders. Each ring array consisted of 55 elements operating near 5 MHz with interelement spacing of 0.20 mm. It was constructed on a flat piece of copper-clad polyimide and then wrapped around an 11 French O.D. catheter. We used a braided cabling technology from Tyco Electronics Corporation to connect the elements to the Volumetric Medical Imaging (VMI) real-time 3-D ultrasound scanner. Transducer performance yielded a -6 dB fractional bandwidth of 20% centered at 4.7 MHz without a matching layer vs. average bandwidth of 60% centered at 4.4 MHz with a matching layer. Real-time 3-D rendered images of an en face view of a Gore Helex septal occluder in a water tank showed a finer texture of the device surface from the ring array with the matching layer.
Asunto(s)
Tabique Interatrial/diagnóstico por imagen , Ecocardiografía/instrumentación , Aumento de la Imagen/instrumentación , Imagenología Tridimensional/instrumentación , Dispositivo Oclusor Septal , Transductores , Tabique Interatrial/cirugía , Sistemas de Computación , Diseño de Equipo , Análisis de Falla de Equipo , Humanos , Fantasmas de Imagen , Reproducibilidad de los Resultados , Sensibilidad y EspecificidadRESUMEN
As a treatment for aortic stenosis, several companies have recently introduced prosthetic heart valves designed to be deployed through a catheter using an intravenous or transapical approach. This procedure can either take the place of open heart surgery with some ofthe devices or delay it with others. Real-time 3D ultrasound could enable continuous monitoring of these structures before, during and after deployment. We have developed a 2D ring array integrated with a 30 French catheter that is used for transapical prosthetic heart valve implantation. The transducer array was built using three 46 cm long flex circuits from MicroConnex (Snoqualmie, WA) which terminate in an interconnect that plugs directly into our system cable; thus, no cable soldering is required. This transducer consists of 210 elements at 0.157 mm interelement spacing and operates at 5 MHz. Average measured element bandwidth was 26% and average round-trip 50 ohm insertion loss was -58.1 dB after correcting for diffractive losses. The transducer was wrapped around the 1 cm diameter lumen of a heart-valve deployment catheter. Prosthetic heart valve images were obtained in water-tank studies.
Asunto(s)
Estenosis de la Válvula Aórtica/terapia , Ecocardiografía Tridimensional/instrumentación , Implantación de Prótesis de Válvulas Cardíacas/métodos , Prótesis Valvulares Cardíacas , Transductores , Ultrasonografía Intervencional/instrumentación , Cateterismo Cardíaco , Diseño de Equipo , Implantación de Prótesis de Válvulas Cardíacas/instrumentación , HumanosRESUMEN
In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.
Asunto(s)
Neoplasias Encefálicas/terapia , Glioblastoma/terapia , Hipertermia Inducida/instrumentación , Cirugía Asistida por Computador/instrumentación , Transductores , Ultrasonografía Intervencional/instrumentación , Animales , Angiografía Cerebral , Modelos Animales de Enfermedad , Diseño de Equipo , Estudios de Factibilidad , Ratones , Ratones Desnudos , Fantasmas de Imagen , Oveja Doméstica , PorcinosRESUMEN
Because stroke remains an important and time-sensitive health concern in developed nations, we present a system capable of fusing 3-D transcranial ultrasound volumes acquired from two sides of the head. This system uses custom sparse array transducers built on flexible multilayer circuits that can be positioned for simultaneous imaging through both temporal acoustic windows, allowing for potential registration of multiple real-time 3-D scans of cerebral vasculature. We examine hardware considerations for new matrix arrays-transducer design and interconnects-in this application. Specifically, it is proposed that SNR may be increased by reducing the length of probe cables. This claim is evaluated as part of the presented system through simulation, experimental data, and in vivo imaging. Ultimately, gains in SNR of 7 dB are realized by replacing a standard probe cable with a much shorter flex interconnect; higher gains may be possible using ribbon-based probe cables. In vivo images are presented, showing cerebral arteries with and without the use of microbubble contrast agent; they have been registered and fused using a simple algorithm which maximizes normalized cross-correlation.
Asunto(s)
Arterias Cerebrales/diagnóstico por imagen , Ecoencefalografía/instrumentación , Procesamiento de Imagen Asistido por Computador/métodos , Adulto , Algoritmos , Encéfalo/irrigación sanguínea , Simulación por Computador , Femenino , Humanos , Angiografía por Resonancia Magnética , Masculino , Microburbujas , Reproducibilidad de los Resultados , TransductoresRESUMEN
An autonomous multiple-core biopsy system guided by real-time 3D ultrasound and operated by a robotic arm with 6+1 degrees of freedom has been developed. Using a specimen of turkey breast as a tissue phantom, our system was able to first autonomously locate the phantom in the image volume and then perform needle sticks in each of eight sectors in the phantom in a single session, with no human intervention required. Based on the fraction of eight sectors successfully sampled in an experiment of five trials, a success rate of 93% was recorded. This system could have relevance in clinical procedures that involve multiple needle-core sampling such as prostate or breast biopsy.
Asunto(s)
Biopsia con Aguja/métodos , Imagenología Tridimensional , Robótica , Ultrasonografía Intervencional , Animales , Diseño de Equipo , Procesamiento de Imagen Asistido por Computador , Fantasmas de Imagen , TurquíaRESUMEN
Feasibility studies of autonomous robot biopsies in tissue have been conducted using real-time three-dimensional (3-D) ultrasound combined with simple thresholding algorithms. The robot first autonomously processed 3-D image volumes received from the ultrasound scanner to locate a metal rod target embedded in turkey breast tissue simulating a calcification, and in a separate experiment, the center of a water-filled void in the breast tissue simulating a cyst. In both experiments the robot then directed a needle to the desired target, with no user input required. Separate needle-touch experiments performed by the image-guided robot in a water tank yielded an rms error of 1.15 mm. (E-mail: kaicheng.liang@duke.edu).
Asunto(s)
Biopsia con Aguja/métodos , Mama/patología , Imagenología Tridimensional/métodos , Robótica/instrumentación , Cirugía Asistida por Computador/instrumentación , Ultrasonografía Intervencional/métodos , Algoritmos , Animales , Estudios de Factibilidad , Femenino , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional/instrumentación , Modelos Biológicos , Fantasmas de Imagen , Reproducibilidad de los Resultados , PavosRESUMEN
Vibrations can be induced in ferromagnetic shrapnel by a variable electromagnet. Real time 3-D color Doppler ultrasound located the induced motion in a needle fragment and determined its 3-D position in the scanner coordinates. This information was used to guide a robot which moved a probe to touch the shrapnel fragment.
Asunto(s)
Compuestos Ferrosos/análisis , Cuerpos Extraños/diagnóstico por imagen , Imagenología Tridimensional/instrumentación , Robótica/instrumentación , Cirugía Asistida por Computador/instrumentación , Ultrasonografía Doppler en Color/instrumentación , Ultrasonografía Intervencional/instrumentación , Cuerpos Extraños/cirugía , Humanos , Cirugía Asistida por Computador/métodos , TransductoresRESUMEN
In this study, we investigated the feasibility of an intracranial catheter transducer with dual-mode capability of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: first by using a 50-element linear array transducer (17 mm x 3.1 mm aperture) operating at 4.4 MHz with our Volumetrics diagnostic scanner and custom, electrical impedance-matching circuits to achieve a temperature rise over 4 degrees C in excised pork muscle, and second, by designing and constructing a 12 Fr, integrated matrix and linear-array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements diced on a 0.2 mm pitch, with a total aperture size of 8.4 mm x 2.3 mm. This 3.64 MHz array achieved a 3.5 degrees C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav catheter as a gold standard in experiments assessing image quality and therapeutic potential and both probes were used in an in vivo canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating.
Asunto(s)
Neoplasias Encefálicas/terapia , Cateterismo/métodos , Hipertermia Inducida/métodos , Imagenología Tridimensional/métodos , Ultrasonografía Doppler en Color/métodos , Ultrasonografía Intervencional/métodos , Animales , Neoplasias Encefálicas/diagnóstico por imagen , Cateterismo/instrumentación , Perros , Diseño de Equipo , Estudios de Factibilidad , Hipertermia Inducida/instrumentación , Imagenología Tridimensional/instrumentación , Fantasmas de Imagen , Porcinos , Transductores , Ultrasonografía Doppler en Color/instrumentación , Ultrasonografía Intervencional/instrumentaciónRESUMEN
We have previously described miniature 2D array transducers integrated into a Cook Medical, Inc. vena cava filter deployment device. While functional, the fabrication technique was very labor intensive and did not lend itself well to efficient fabrication of large numbers of devices. We developed two new fabrication methods that we believe can be used to efficiently manufacture these types of devices in greater than prototype numbers. One transducer consisted of 55 elements operating near 5 MHz. The interelement spacing is 0.20 mm. It was constructed on a flat piece of copper-clad polyimide and then wrapped around an 11 French catheter of a Cook Medical, Inc. inferior vena cava (IVC) filter deployment device. We used a braided wiring technology from Tyco Electronics Corp. to connect the elements to our real-time 3D ultrasound scanner. Typical measured transducer element bandwidth was 20% centered at 4.7 MHz and the 50 Omega round trip insertion loss was --82 dB. The mean of the nearest neighbor cross talk was -37.0 dB. The second method consisted of a 46-cm long single layer flex circuit from MicroConnex that terminates in an interconnect that plugs directly into our system cable. This transducer had 70 elements at 0.157 mm interelement spacing operating at 4.8 MHz. Typical measured transducer element bandwidth was 29% and the 50 Omega round trip insertion loss was -83 dB. The mean of the nearest neighbor cross talk was -33.0 dB.
Asunto(s)
Imagenología Tridimensional/métodos , Transductores , Ultrasonografía Doppler en Color/métodos , Ultrasonografía Intervencional/instrumentación , Prótesis Vascular , Diseño de Equipo , Ultrasonografía Intervencional/métodos , Filtros de Vena CavaRESUMEN
We have previously developed 2-D array transducers for many real-time volumetric imaging applications. These applications include transducers operating up to 7 MHz for transthoracic imaging, up to 15 MHz for intracardiac echocardiography (ICE), 5 MHz for transesophageal echocardiography (TEE) and intracranial imaging, and 7 MHz for laparoscopic ultrasound imaging (LUS). Now we have developed a new generation of miniature ring-array transducers integrated into the catheter deployment kits of interventional devices to enable real-time 3-D ultrasound scanning for improved guidance of minimally invasive procedures. We have constructed 3 new ring transducers. The first consists of 54 elements operating at 5 MHz. Typical measured transducer element bandwidth was 25%, and the 50 Ohm round trip insertion loss was -65 dB. Average nearest neighbor cross talk was -23.8 dB. The second is a prototype 108-element transducer operating at 5 MHz. The third is a prototype 108-element ring array with a transducer center frequency of 8.9 MHz and a -6 dB bandwidth of 25%. All transducers were integrated with an 8.5 French catheter sheath of a Cook Medical, Inc. vena cava filter deployment device.
Asunto(s)
Cateterismo Venoso Central/instrumentación , Cateterismo Venoso Central/métodos , Imagenología Tridimensional/instrumentación , Cirugía Asistida por Computador/instrumentación , Ultrasonografía Intervencional/instrumentación , Filtros de Vena Cava , Diseño de Equipo , Análisis de Falla de Equipo , Humanos , Imagenología Tridimensional/métodos , Fantasmas de Imagen , Ultrasonografía Intervencional/métodosRESUMEN
A miniature motor rotating at 11,000 rpm was attached onto the proximal end of cardiac electrophysiological (EP) catheters in order to produce vibrations at the tip that were then visualized by color Doppler on ultrasound scanners. The catheter tip was imaged within a vascular graft submerged in a water tank using the Volumetrics Medical Imaging 3D scanner, the Siemens Sonoline Antares 2D scanner and the Philips ie33 3D ultrasound scanner with TEE probe. The vibrating catheter tip was visualized in each case, although results varied with the color Doppler properties of the individual scanner.
Asunto(s)
Cateterismo Cardíaco/instrumentación , Ultrasonografía Doppler en Color/métodos , Ultrasonografía Intervencional/instrumentación , Vibración , Prótesis Vascular , Electrofisiología , Diseño de Equipo , Imagenología Tridimensional/métodosRESUMEN
We integrated electrocardiogram (ECG) leads onto the face of a cardiac ultrasound transducer and the exterior chassis of a simulated small, portable scanner to minimize the number of devices needed to collect cardiac information. Since the ECG leads were not placed on their standard locations, a precordial ECG was recorded.
Asunto(s)
Electrocardiografía , Ultrasonografía/instrumentación , Diseño de Equipo , Estudios de Factibilidad , Humanos , TransductoresRESUMEN
A transducer originally designed for transesophageal echocardiography (TEE) was adapted for real-time volumetric endoscopic imaging of the brain. The transducer consists of a 36 x 36 array with an interelement spacing of 0.18 mm. There are 504 transmitting and 252 receive channels placed in a regular pattern in the array. The operating frequency is 4.5 MHz with a -6 dB bandwidth of 30%. The transducer is fabricated on a 10-layer flexible circuit from Microconnex (Snoqualmie, WA, USA). The purpose of this study is to evaluate the clinical feasibility of real-time 3-D intracranial ultrasound with this device. The Volumetrics Medical Imaging (Durham, NC, USA) 3-D scanner was used to obtain images in a canine model. A transcalvarial acoustic window was created under general anesthesia in the animal laboratory by placing a 10-mm burr hole in the high parietal calvarium of a 50-kg canine subject. The burr-hole was placed in a left parasagittal location to avoid the sagittal sinus, and the transducer was placed against the intact dura mater for ultrasound imaging. Images of the lateral ventricles were produced, including real-time 3-D guidance of a needle puncture of one ventricle. In a second canine subject, contrast-enhanced 3-D Doppler color flow images were made of the cerebral vessels including the complete Circle of Willis. Clinical applications may include real-time 3-D guidance of cerebrospinal fluid extraction from the lateral ventricles and bedside evaluation of critically ill patients where computed tomography and magnetic resonance imaging techniques are unavailable.
Asunto(s)
Ecoencefalografía/métodos , Ultrasonografía Intervencional/métodos , Animales , Arteria Cerebral Anterior/patología , Encéfalo/patología , Arteria Carótida Interna/patología , Medios de Contraste , Perros , Ecoencefalografía/instrumentación , Diseño de Equipo , Imagenología Tridimensional/instrumentación , Imagenología Tridimensional/métodos , Cuidados Intraoperatorios/métodos , Angiografía por Resonancia Magnética/métodos , Fantasmas de Imagen , TransductoresRESUMEN
Laparoscopic ultrasound has seen increased use as a surgical aide in general, gynecological, and urological procedures. The application of real-time, three-dimensional (RT3D) ultrasound to these laparoscopic procedures may increase information available to the surgeon and serve as an additional intraoperative guidance tool. The integration of RT3D with recent advances in robotic surgery also can increase automation and ease of use. In this study, a 1-cm diameter probe for RT3D has been used laparoscopically for in vivo imaging of a canine. The probe, which operates at 5 MHz, was used to image the spleen, liver, and gall bladder as well as to guide surgical instruments. Furthermore, the three-dimensional (3-D) measurement system of the volumetric scanner used with this probe was tested as a guidance mechanism for a robotic linear motion system in order to simulate the feasibility of RT3D/robotic surgery integration. Using images acquired with the 3-D laparoscopic ultrasound device, coordinates were acquired by the scanner and used to direct a robotically controlled needle toward desired in vitro targets as well as targets in a post-mortem canine. The rms error for these measurements was 1.34 mm using optical alignment and 0.76 mm using ultrasound alignment.
Asunto(s)
Imagenología Tridimensional/instrumentación , Laparoscopios , Robótica/instrumentación , Transductores , Ultrasonografía Intervencional/instrumentación , Animales , Perros , Diseño de Equipo , Análisis de Falla de Equipo , Estudios de Factibilidad , Imagenología Tridimensional/métodos , Laparoscopía/métodos , Robótica/métodos , Integración de Sistemas , Ultrasonografía Intervencional/métodosRESUMEN
Modifications were made to a commercial real-time, three-dimensional (3-D) ultrasound system for near simultaneous 3-D scanning with two matrix array transducers. As a first illustration, a transducer cable assembly was modified to incorporate two independent, 3-D intra-cardiac echo catheters, a 7 Fr (2.3 mm O.D.) side scanning catheter and a 14 Fr (4.7 mm O.D) forward viewing catheter with accessory port, each catheter using 85 channels operating at 5 MHz. For applications in treatment of atrial fibrillation, the goal is to place the sideviewing catheter within the coronary sinus to view the whole left atrium, including a pulmonary vein. Meanwhile, the forward-viewing catheter inserted within the left atrium is directed toward the ostium of a pulmonary vein for therapy using the integrated accessory port. Using preloaded, phasing data, the scanner switches between catheters automatically, at the push of a button, with a delay of about 1 second, so that the clinician can view the therapy catheter with the coronary sinus catheter and vice versa. Preliminary imaging studies in a tissue phantom and in vivo show that our system successfully guided the forward-viewing catheter toward a target while being imaged with the sideviewing catheter. The forward-viewing catheter then was activated to monitor the target while we mimicked therapy delivery. In the future, the system will switch between 3-D probes on a line-by-line basis and display both volumes simultaneously.
Asunto(s)
Algoritmos , Ecocardiografía Tridimensional/instrumentación , Aumento de la Imagen/instrumentación , Interpretación de Imagen Asistida por Computador/instrumentación , Imagenología Tridimensional/instrumentación , Transductores , Animales , Sistemas de Computación , Perros , Ecocardiografía Tridimensional/métodos , Diseño de Equipo , Análisis de Falla de Equipo , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Almacenamiento y Recuperación de la Información/métodos , Reproducibilidad de los Resultados , Sensibilidad y EspecificidadRESUMEN
We have previously described 2D array ultrasound transducers operating up to 10 MHz for applications including real time 3D transthoracic imaging, real time volumetric intracardiac echocardiography (ICE), real time 3D intravascular ultrasound (IVUS) imaging, and real time 3D transesophageal echocardiography (TEE). We have recently built a pair of 2D array transducers for real time 3D laparoscopic ultrasonography (3D LUS). These transducers are intended to be placed down a trocar during minimally invasive surgery. The first is a forward viewing 5 MHz, 11 x 19 array with 198 operating elements. It was built on an 8 layer multilayer flex circuit. The interelement spacing is 0.20 mm yielding an aperture that is 2.2 mm x 3.8 mm. The O.D. of the completed transducer is 10.2 mm and includes a 2 mm tool port. The average measured center frequency is 4.5 MHz, and the -6 dB bandwidth ranges from 15% to 30%. The 50 omega insertion loss, including Gore MicroFlat cabling, is -81.2 dB. The second transducer is a 7 MHz, 36 x 36 array with 504 operating elements. It was built upon a 10 layer multilayer flex circuit. This transducer is in the forward viewing configuration and the interelement spacing is 0.18 mm. The total aperture size is 6.48 mm x 6.48 mm. The O.D. of the completed transducer is 11.4 mm. The average measured center frequency is 7.2 MHz, and the -6 dB bandwidth ranges from 18% to 33%. The 50 omega insertion loss is -79.5 dB, including Gore MicroFlat cable. Real-time in vivo 3D images of canine hearts have been made including an apical 4-chamber view from a substernal access with the first transducer to monitor cardiac function. In addition, we produced real time 3D rendered images of the right pulmonary veins from a right parastemal access with the second transducer, which would be valuable in the guidance of cardiac ablation catheters for treatment of atrial fibrillation.
Asunto(s)
Imagenología Tridimensional/instrumentación , Laparoscopía/métodos , Venas Pulmonares/diagnóstico por imagen , Ultrasonografía Intervencional/instrumentación , Animales , Perros , Ecocardiografía Tridimensional/instrumentación , Fantasmas de Imagen , TransductoresRESUMEN
We tested the feasibility of real-time, 3-D ultrasound (US) imaging in the brain. The 3-D scanner uses a matrix phased-array transducer of 512 transmit channels and 256 receive channels operating at 2.5 MHz with a 15-mm diameter footprint. The real-time system scans a 65 degrees pyramid, producing up to 30 volumetric scans per second, and features up to five image planes as well as 3-D rendering, 3-D pulsed-wave and color Doppler. In a human subject, the real-time 3-D scans produced simultaneous transcranial horizontal (axial), coronal and sagittal image planes and real-time volume-rendered images of the gross anatomy of the brain. In a transcranial sheep model, we obtained real-time 3-D color flow Doppler scans and perfusion images using bolus injection of contrast agents into the internal carotid artery.
Asunto(s)
Ecoencefalografía/métodos , Animales , Ventrículos Cerebrales/diagnóstico por imagen , Circulación Cerebrovascular , Medios de Contraste , Estudios de Factibilidad , Humanos , Masculino , Persona de Mediana Edad , Polisacáridos , Ovinos , Ultrasonografía Doppler en Color/métodosRESUMEN
We have previously described 2D arrays operating at up to 10.0 MHz consisting of several thousand elements for transthoracic cardiac imaging and over a hundred elements for intracardiac imaging using 7 Fr to 12 Fr catheters. We have begun to explore forward viewing real time 3D phased array intravascular ultrasound, which may require imaging depths of a few centimeters to look down the axis of a vessel to view vulnerable atherosclerotic plaque. We used a noncoaxial based cable technology that allowed 100 signal wires to be placed inside a4.8 French IVUS lumen with an inner diameter of 1.3 mm. We pursued two different fabrication technologies for the building of the transducers. Each transducer was constructed in the forward viewing configuration to allow simultaneous real time B-scans, C-scans and volumetric rendering of vessels and vascular stents distal to the catheter tip. In order to obtain the desired penetration depth, each transducer was constructed to operate at 10.0 MHz. The first method included an ordered array of 11 x 11 = 121 elements. In order to conform to the round aperture of the IVUS lumen, the comers were cut off, resulting in a total of 97 signal channels. Real time images include a 4 mm diameter vessel in a tissue mimicking phantom, an expanded stent and a stent in an excised sheep aorta. The second method is based upon a laser dicing technique that cuts the individual elements in a random pattern. This resulted in 61 signal channels. Real time 3D images of the AIUM test object were made with this transducer.
Asunto(s)
Vasos Coronarios/diagnóstico por imagen , Imagenología Tridimensional/instrumentación , Transductores , Ultrasonografía Intervencional/instrumentación , Animales , Aorta/diagnóstico por imagen , Endosonografía/instrumentación , Diseño de Equipo , Fantasmas de Imagen , Ovinos , StentsRESUMEN
We investigated the feasibility of the guidance of pacemaker lead implantation using the pacemaker lead stylet as an acoustic wave-guide combined with real time 3D ultrasound imaging. In one approach, with a 2.5 MHz transducer coupled to a stylet of a pacemaker lead, we used the stylet as a transmitter to track the vibrating tip in a 3D ultrasound scan. In another approach, we connected the stylet to a piezoelectric actuator vibrating in the range 0.5-5 kHz so that the tip of the stylet was imaged using the color Doppler feature of the real time 3D ultrasound scanner. In both approaches, tracking of the isolated stylet showed good accuracy. However, neither approach offered sufficient signal-to-noise ratio to detect the vibration within the lumen of an intact pacemaker lead.
Asunto(s)
Marcapaso Artificial , Ultrasonografía Doppler/métodos , Animales , Electrodos Implantados , Estudios de Factibilidad , Imagenología Tridimensional , Modelos Animales , Ovinos , Ultrasonografía Doppler/instrumentaciónRESUMEN
Using catheter-mounted two-dimensional array transducers, we have obtained real-time three-dimensional color flow and spectral Doppler ultrasound images in phantoms. We have constructed several transducers operating at 5 MHz with up to 137 channels inside a 12 French catheter lumen. The transducer configuration may be side scanning or beveled with respect to the long axis of the catheter lumen. We have also included six electrodes to acquire simultaneous electrocardiograms. We have measured Doppler signals in two phantoms, a string phantom and a pulsatile flow phantom. Using an open chest sheep model, we inserted the catheter into the cardiac chambers to study the utility of in vivo 3D intracardiac Doppler echocardiography.