Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine.

Introduction: Dexmedetomidine (DXM) is widely used as an adjuvant to anesthesia or a sedative medicine, and differences in individual sensitivity to the drug exist. This study aimed to investigate the effect of genetic polymorphisms on these differences. Methods: A total of 112 patients undergoing hand surgery were recruited. DXM 0.5 µg/kg was administered within 10 min and then continuously injected (0.4 µg/kg/h). Narcotrend index, effective dose and onset time of sedation, MAP, and HR were measured. Forty-five single nucleotide polymorphisms (SNPs) were selected for genotype. Results: We observed individual differences in the sedation and hemodynamics induced by DXM. ABCG2 rs2231142, CYP2D6 rs16947, WBP2NL rs5758550, KATP rs141294036, KCNMB1 rs11739136, KCNMA1 rs16934182, ABCC9 rs11046209, ADRA2A rs1800544, and ADRB2 rs1042713 were shown to cause statistically significant (p < 0.05) influence on the individual variation of DXM on sedation and hemodynamics. Moreover, the multiple linear regression analysis indicated sex, BMI, and ADRA2A rs1800544 are statistically related to the effective dose of DXM sedation. Discussion: The evidence suggests that the nine SNPs involved in transport proteins, metabolic enzymes, and target proteins of DXM could explain the individual variability in the sedative and hemodynamic effects of DXM. Therefore, with SNP genotyping, these results could guide personalized medication and promote clinical and surgical management.

Changes in the live birth profile in Henan, China: A hospital registry-based study.

BACKGROUND: Preterm complications and neonatal asphyxia are the leading causes of death in those under 5 years of age. However, little information exists for the province of Henan, China. The purpose of this study was to explore changes in the live birth profile in a provincial hospital over the past 32 years in Henan, China. METHODS: A retrospective analysis was conducted to reveal the characteristics of live neonates from 1987 to 2018. RESULTS: There were 118 253 live births during the period, including 19 798 (16.74%) preterm births. The neonatal death rate was 6.45‰, and the top risk factor was preterm birth complications and birth asphyxia. Before 1998, neonatal death occurred primarily among term infants. Between 1999 and 2018, preterm infants, especially extreme and very preterm infants with very low birthweight, constituted more than half of all mortalities, and the preterm birth rate increased from 5.94% in 1999 to 16.69% in 2018. The risk factors associated with preterm birth were being male (aOR = 1.18, P < 0.001), advanced maternal age (>35 years old; aOR = 1.08, P = 0.008), gravidity ≥2 (aOR = 1.15, P < 0.001), parity ≥2 (aOR = 1.50, P < 0.001), placenta previa (aOR = 7.41, P < 0.001), twin or multiple births (aOR = 10.63, P < 0.001), hypertension (aOR = 2.08, P < 0.001), and rupture of membrane (aOR = 5.03, P < 0.001). CONCLUSIONS: The preterm birth rate has increased over the past 32 years from 4.98% to 16.69% in a provincial hospital in China. Preterm birth was the leading reason for neonatal death, and birth asphyxia was the major risk factor for death in term infants.

Comparative study on the influence of two kinds of different self-locking brackets on the dental arch shape change in non-extraction patients / 口腔疾病防治

Objective@# By analyzing changes of dental arch width and length during the aligning and leveling period (non-extraction case) with two kinds of self-locking bracket, compare the difference between the active self-locking bracket with the passive bracket.@*Methods@#The data of dental arch perimeter change amount and dental arch width and length change amount (WU/L3, WU/L4, WU/L5, WU/L6, U/LL) were statistically analyzed using the correlation and regression method by comparing active and passive brackets for the correction of dental arch variations. Two different brackets for the correction of the measured values of the dental arch variations was analyzed by t-test. Results There were statistical relationships between the amount of arch perimeter increase and the amount of width and length increase. The regression equation was statistically significant (P < 0.05), It was greater impacted arch width increase to arch perimeter in the self-locking. The t-test results showed WU3, WL3, WL6, LR 4 measured values (P < 0.05) statistically significant in the active self-locking group and passive group. @*Results @#There were statistical relationships between the amount of arch perimeter increase and the amount of width and length increase. The regression equation was statistically significant (P < 0.05), It was greater impacted arch width increase to arch perimeter in the self-locking. The t-test results showed WU3, WL3, WL6, LR 4 measured values (P < 0.05) statistically significant in the active self-locking group and passive group. @*Conclusin @#Active and passive self-locking bracket have good arch expansion effecting. The active self-locking bracket is slightly dominant than the passive bracket in the expansion of the canine width whereas the active self-locking bracket is better than the passive in the expansion of the mandibular first molar and arch perimeter which should be widely applied to the appropriate cases.

Trends in live births in the past 20 years in Zhengzhou, China.

OBJECTIVE: To evaluate changing trends in neonatal births and deaths in a provincial women's and children's hospital over the past 20 years. DESIGN: Retrospective longitudinal study. SETTING: Henan Provincial Women's and Children's Hospital, China. POPULATION: Live births in Henan Provincial Women's and Children's Hospital from January 1987 to December 2006. METHODS: Data was stratified by sex, birth weight, delivery type, maternal age, gestational age, and single or multiple births. The incidence of low Apgar scores and neonatal death was calculated for each fiscal year. MAIN OUTCOME MEASURES: Trends in the fundamental status of hospital-born live births and risk factors for neonatal death. RESULTS: 26 760 hospital live births were included. The ratio of males to females was 1.16:1. The mean gestational age decreased from 39.5±1.4 weeks to 38.4±2.5 weeks (p <0.001) and multiple births increased from 1.5 to 7.3% (p<0.001). The proportion of preterm births increased from 4.7 to 18.9% (p<0.001), maternal age increased from 25.9±3.7 years to 29.0±4.4 years (p<0.001), and cesarean deliveries increased from 23.7 to 65.5% (p<0.001). The incidence of low Apgar scores decreased from 12.9 to 1.1% (p<0.001). The incidence of neonatal death was 8.5/1 000 live births, with preterm births and low Apgar scores accounting for 72.8 and 16.2% of all neonatal deaths, respectively. CONCLUSION: Preterm births, multiple births, and cesarean deliveries increased dramatically. Preterm birth is the leading cause of neonatal death.