Nutritional load in post-prandial oxidative stress and the pathogeneses of diabetes mellitus.

Diabetes mellitus affected more than 500 million of people globally, with an annual mortality of 1.5 million directly attributable to diabetic complications. Oxidative stress, in particularly in post-prandial state, plays a vital role in the pathogenesis of the diabetic complications. However, oxidative status marker is generally poorly characterized and their mechanisms of action are not well understood. In this work, we proposed a new framework for deep characterization of oxidative stress in erythrocytes (and in urine) using home-built micro-scale NMR system. The dynamic of post-prandial oxidative status (against a wide variety of nutritional load) in individual was assessed based on the proposed oxidative status of the red blood cells, with respect to the traditional risk-factors such as urinary isoprostane, reveals new insights into our understanding of diabetes. This new method can be potentially important in drafting guidelines for sub-stratification of diabetes mellitus for clinical care and management.

Enhancing squat movement classification performance with a gated long-short term memory with transformer network model.

Bodyweight squat is one of the basic sports training exercises. Automatic classification of aberrant squat movements can guide safe and effective bodyweight squat exercise in sports training. This study presents a novel gated long-short term memory with transformer network (GLTN) model for the classification of bodyweight squat movements. Twenty-two healthy young male participants were involved in an experimental study, where they were instructed to perform bodyweight squat in nine different movement patterns, including one acceptable movement defined according to the National Strength and Conditioning Association and eight aberrant movements. Data were acquired from four customised inertial measurement units placed at the thorax, waist, right thigh, and right shank, with a sampling frequency of 200 Hz. The results show that compared to state-of-art deep learning models, our model enhances squat movement classification performance with 96.34% accuracy, 96.31% precision, 96.45% recall, and 96.32% F-score. The proposed model provides a feasible wearable solution to monitoring aberrant squat movements that can facilitate performance and injury risk assessment during sports training. However, this model should not serve as a one-size-fits-all solution, and coaches and practitioners should consider individual's specific needs and training goals when using it.

Infection of sheep by Echinococcus multilocularis in Gansu, China: evidence from mitochondrial and nuclear DNA analysis.

BACKGROUND: In the normal life cycle of the parasite (Echinococcus multilocularis) that causes alveolar echinococcosis, domestic and wild carnivores act as definitive hosts, and rodents act as intermediate hosts. The presented study contributes to the research on the distribution and transmission pattern of E. multilocularis in China having identified sheep as an unusual intermediate host taking part in the domestic transmission of alveolar echinococcosis in Gansu Province, China. METHODS: From 2020 to 2021, nine whitish different cyst-like were collected from the liver of sheep in Gansu Province for examination. A near complete mitochondrial (mt) genome and selected nuclear genes were amplified from the cyst-like lesion for identification. To confirm the status of the specimen, comparative analysis with reference sequences, phylogenetic analysis, and network analysis were performed. RESULTS: The isolates displayed ≥ 98.87% similarity to E. multilocularis NADH dehydrogenase sub-unit 1 (nad1) (894 bp) reference sequences deposited in GenBank. Furthermore, amplification of the nad4 and nad2 genes also confirmed all nine samples as E. multilocularis with > 99.30% similarity. Additionally, three nuclear genes, pepck (1545 bp), elp-exons VII and VIII (566 bp), and elp-exon IX (256 bp), were successfully amplified and sequenced for one of the isolates with 98.42% similarity, confirming the isolates were correctly identified as E. multilocularis. Network analysis also correctly placed the isolates with other E. multilocularis. CONCLUSIONS: As a result of the discovery of E. multilocularis in an unusual intermediate host, which is considered to have the highest zoonotic potential, the result clearly demonstrated the necessity for expanded surveillance in the area.

Influence of load knowledge on lifting biomechanics.

Objectives. Findings from previous studies implied that appropriately controlling load knowledge might help improve the biomechanical performance during lifting tasks. However, only load weight knowledge was often discussed in previous studies. The current study aimed to complement the existing studies and provide improved knowledge about the influence of load knowledge on lifting biomechanics. Methods. Twenty-four healthy male participants were recruited and instructed to perform symmetric lifting tasks with different load weights under different load knowledge conditions. Load weights were set at three levels (40, 80 and 120%) of each participant's maximum acceptable lifting capacity. The examined load knowledge conditions included 'no knowledge' condition, 'weight known' condition, 'fragile material known' condition and 'weight and fragile material known' condition. Results. We found that when knowing fragility information about lifting materials, workers tended to be more cautious by adopting a less dynamic motion pattern during the landing phase, as evidenced by decreases of 6-8% in elbow joint acceleration. The 'cautious' lifting pattern when fragility load knowledge was presented could contribute to reduced risk of lower back disorder. Conclusion. This finding could help to develop lower back disorder prevention interventions to improve occupational safety and health.

Evaluation of force-time curve analysis methods in the isometric mid-thigh pull test.

The purpose of this study was to evaluate the manual and automatic analysis methods for force-time curve analysis of the isometric mid-thigh pull (IMTP) test. The visual analysis, first derivative analysis and threshold analysis methods were used to analyse onset time and time-specific forces at 50 ms, 90 ms, 200 ms and 250 ms on the force-time curve. Ninety-three collegiate sports athletes' trials were selected and analysed by each method. The visual analysis method was set as the reference method for paired comparisons with the first derivative analysis method and threshold analysis method. Onset time comparisons revealed that the first derivative analysis method was comparable with the visual analysis method with average difference at about 30 ms. Results from the weighted least products regression analysis and the Bland-Altman analysis showed that large fixed bias confounded by proportional bias existed in the threshold analysis method, and time-specific force variables obtained from the first derivative analysis method were closer to those from the visual analysis method when compared with the threshold analysis method. These findings suggest that the first derivative analysis method could be an effective tool for force-time curve analysis of the IMTP test.

Exploring the environmental properties and resource utilization of construction waste in Beijing-Tianjin-Hebei region.

Beijing-Tianjin-Hebei region is a capital economic circle for the future. Promoting the coordinated development of its population, economy, resources and environment is a major national strategy. And as towns and cities continue to expand, the volume of construction waste is gradually expanding, posing a major challenge to the sustainable development of the construction industry. In order to solve this problem, this paper used portable X-ray fluorescence spectrometry to realize the on-site rapid monitoring of heavy metals in construction waste, and the correlation analysis result was R2 = 0.9908. The visualization of enrichment factor evaluation results was realized through ArcGIS. The Beijing-Tianjin-Hebei region is mainly polluted by heavy metal elements Cr, Zn, Pb and Hg, showing regional pollution characteristics, and the results of mercury morphology analysis show that all are inorganic mercury pollution, and methylmercury is not detected, and the cause can be traced to heavy industrial production in Tangshan City, which is consistent with industrial ecology. The results of leaching toxicity and cation anion analysis showed that the construction waste in Beijing-Tianjin-Hebei region had environmental risks to the surrounding surface water and groundwater. The resource treatment and disposal path were determined by means of XRD, ternary phase diagram and oxide composition analysis to avoid secondary pollution. This study explores the environmental properties and resource utilization pathways of construction waste in the Beijing-Tianjin-Hebei region, laying the foundation for research work on construction waste in the development of national urban agglomerations, effectively solving regional environmental pollution problems and promoting the sustainable development of the construction industry.

Influence of Load Knowledge on Biomechanics of Asymmetric Lifting.

BACKGROUND: Load knowledge has been identified as a factor affecting the risk of low back pain (LBP) during symmetric lifting. However, the effects of load knowledge in asymmetric lifting tasks have not been reported yet. The purpose of this study was to investigate the load knowledge influence on lifting biomechanics in asymmetric lifting tasks; Methods: Twenty-four male adults were recruited to complete a psychophysical lifting capacity test and a simulated asymmetric lifting task. The lifting task was set with load knowledge of 'no knowledge' (NK), 'weight known' (WK), 'fragile material known' (FK), and 'weight and fragile material known' (WFK) for different lifting load weights. Trunk kinematics and kinetics were collected and analyzed; Results: When fragility information was presented, trunk sagittal flexion acceleration, lateral flexion velocity and acceleration, and average lateral bending moment were significantly lowered at the deposit phase. Lifting a high load weight was found to significantly increase low back sagittal bending moment at the lifting phase and low back moments of all three dimensions at the deposit phase; Conclusions: The decrease of trunk kinematic load suggests that providing material fragility information to workers in asymmetric lifting tasks would be effective in reducing their risk of LBP.

Prediction Model for Compressive Strength of Porous Concrete with Low-Grade Recycled Aggregate.

As the first batch of products after the resource utilization of construction and demolition waste, low-grade recycled aggregate (RA) has not been fully utilized, which hinders the development of the comprehensive recycling industry of construction waste. Therefore, this paper studies the mechanical properties of porous concrete (POC) with low-grade RA. An improved relationship between porosity and compressive strength of brittle, porous materials is used to express the compressive strength of POC with recycled aggregate (RPOC), and the prediction for compressive strength of porous concrete with low-grade RA is constructed by analyzing the mechanism of compressive damage. The results show: the compressive strength of porous concrete decreases with the addition of low-grade recycled aggregate, but the effect is not obvious when the replacement rate is less than 25%. The error range of the relationship between porosity and compressive strength of RPOC is basically within 15% after improvement. The prediction model for compressive strength based on the ideal sphere model of aggregate can accurately reflect the compressive strength of porous concrete with low-grade RA. The results of this study can provide a reference for the staff to learn about the functional characteristics of recycled products in advance and provide security for the actual project.

Fast Response Organic Tandem Photodetector for Visible and Near-Infrared Digital Optical Communications.

Organic photodetectors (OPDs), which usually work as photodiodes, photoconductors, or phototransistors, have emerged as candidates for next-generation light sensing. However, low response speed caused by low carrier mobility and resistance-capacitance (RC) time constant, severely hinders the commercialization of OPDs. Herein, the authors demonstrate a state-of-the-art OPD with a record response speed of 146.8 ns by employing tandem structure to simultaneously reduce both the carrier transit time and RC time constant of the device, which is faster than that of previously reported OPDs as far as they know. Moreover, benefitting from the multi-level barrier enhancement and voltage division engendered by tandem structure, an ultralow noise current of 7.82 × 10-14 A Hz-1/2 is obtained, as well as a wide detection range in 300-1000 nm. In addition, the tandem OPDs are successfully integrated into the optical communication system as signal receivers, demonstrating the precise digital signal communication from visible to near-infrared light. It is believed that tandem OPDs have promising application potential in the wireless transmission system.

Periodization and Block Periodization in Sports: Emphasis on Strength-Power Training-A Provocative and Challenging Narrative.

ABSTRACT: Stone, MH, Hornsby, WG, Haff, GG, Fry, AC, Suarez, DG, Liu, J, Gonzalez-Rave, JM, and Pierce, KC. Periodization and block periodization in sports: emphasis on strength-power training-a provocative and challenging narrative. J Strength Cond Res 35(8): 2351-2371, 2021-Periodization can be defined as a logical sequential, phasic method of manipulating fitness and recovery phases to increase the potential for achieving specific performance goals while minimizing the potential for nonfunctional over-reaching, overtraining, and injury. Periodization deals with the micromanagement of timelines and fitness phases and is cyclic in nature. On the other hand, programming deals with the micromanagement of the training process and deals with exercise selection, volume, intensity, etc. Evidence indicates that a periodized training process coupled with appropriate programming can produce superior athletic enhancement compared with nonperiodized process. There are 2 models of periodization, traditional and block. Traditional can take different forms (i.e., reverse). Block periodization has 2 subtypes, single goal or factor (individual sports) and multiple goals or factors (team sports). Both models have strengths and weaknesses but can be "tailored" through creative programming to produce excellent results for specific sports.

Highly sensitive, broadband, fast response organic photodetectors based on semi-tandem structure.

Solution-processed organic photodetectors (OPDs) simultaneously integrating high sensitivity, ultrafast response and broadband detection have rarely been achieved so far. Herein, we demonstrate OPDs based on a semi-tandem structure with remarkable performance by solution-processability. The semi-tandem structure directly superimposes two active layers with complementary absorption spectra, achieving a broad spectral response of 300-1000 nm. It provides a detection covering from ultraviolet to near-infrared range, while the external quantum efficiency in the spectral range of 550-950 nm retains 70%. The high electron and hole injection barriers enable a dark current density as low as 6.51 × 10-5 mA cm-2 at -0.1 V, resulting in a noise current of 3.91 × 10-13 A Hz-1/2 at 70 Hz, which is nearly three times lower than single-junction photodetectors. Encouragingly, the device response speed is improved by suppressing the resistance-capacitance time constant of the device employing semi-tandem structure induced capacitance decreasing. The state-of-the-art OPDs contribute to the response time of 26.27 ns, which is the fastest one in OPDs to the best of our knowledge. We believe that the semi-tandem structures provide a new approach to achieving high-performance photodetectors integrating fast, sensitive and broadband response.

Color and transparency-switchable semitransparent polymer solar cells towards smart windows.

Semitransparent polymer solar cells (ST-PSCs) have attracted worldwide attention owing to unique superiority in multiple utilization of incident light. However, the color of ST-PSCs is relatively uniform after fabrication, cannot be dynamically tuned in terms of application requirement. Herein, we demonstrate a high-efficiency ST-PSCs as a smart window, which can be reversibly switched on and off by a gasochromic tungsten trioxide/platinum (WO3/Pt) back reflector layer. The ST-PSCs can be switchable between colored and bleached states with fast response speed of sub-second during hydrogen exposure. Meanwhile, the color and transparency-switching enable light trapping enhancement in long wavelength range, which can systematically improve power conversion efficiency (PCE). As a result, the ST-PSCs contribute a PCE of 10.2% and 9.1% as well as corresponding average visible transmission (AVT) of 25.4% and 33.8% at colored state and bleached state, respectively, which can meet the visual aesthetics requirement well in building integrated photovoltaics. To the best of our knowledge, this is the first example for ST-PSCs that achieve both color-switching and light trapping. Furthermore, the smart windows facing to automobile sunroof are proposed to prove a practical application towards commercialization. We believe that smart windows with gasochromic functions can promise potential opportunities and directions for the future development of ST-PSCs.

Transepithelial transport of Cerulenin across Caco-2 cell monolayers.

The transepithelial transport of Cerulenin across Caco-2 cell monolayers was examined in this study. The permeated amounts of Cerulenin were measured by HPLC method to calculate the permeation rate and the apparent permeability coefficient (P(app)). The transport of Cerulenin was independent on apical pH and exhibited concentration-dependent and nonsatuable even at 10 mM Cerulenin. The permeation rate at 1 mM Cerulenin in the apical-to-basolateral direction was 0.151 ng/min/mg of protein and the P(app) was 3.76 x 10(-6) cm/second. The permeation rate of Cerulenin was affected by neither metabolic inhibitors nor inhibitors for P-glycoprotein, as was the same case in monolayers treated with cytochalasin D. All these data from experiments indicated that transport of Cerulenin across Caco-2 cell monolayers was not mediated by ATP-dependent transport systems nor via paracellular pathway, but via passive diffusion without efflux by P-glycoprotein.

[Development of a portable ECG monitor with diagnostic & therapeutic functions and its clinical applications].

A portable ECG monitor is introduced in the paper, which has a temporary intravenous and transesophageal fixable rate pacing function. During the PSVT attack, the tachyarrythmia can be stopped by the transesophageal cardiac pacing while the ECG signals are monitored. The instrument has some advantages such as small size, low price and good practicality. It is worth while introducing and popularizing it to all hospitals.

[Development of multi-channels cardiac electrophysiological polygraph with LabVIEW as software platform and its clinical application].

Polygraph has become a necessary instrument in interventional cardiology and fundamental research of medicine up to the present. In this study, a LabView development system (DS) (developed by NI in U.S.) used as software platform, a DAQ data acquisition module and universal computer used as hardware platform, were creatively coupled with our self-made low noise multi-channels preamplifier to develop Multi-channels electrocardiograph. The device possessed the functions such as real time display of physiological process, digit highpass and lowpass, 50Hz filtered and gain adjustment, instant storing, random playback and printing, and process control stimulation. Besides, it was small-sized, economically practical and easy to operate. It could advance the spread of cardiac intervention treatment in hospitals.