OBJECTIVES: The aim of this study is to determine the total, soluble and ionic fluoride (IF) concentration in toothpastes for children since there is a lack of information about this data. METHODS: Fifteen different brands of toothpastes were purchased in different cities in Brazil. The total fluoride (TF), total soluble fluoride (TSF) and IF of two samples of each brand were determined (µg/g F). RESULTS: The concentration of TF found in the fluoride toothpastes ranged from 324.4 to 1466.2 µg/g F, TSF ranged from 214.6 to 1424.1 µg/g F and IF ranged from 108.3 to 1320.1 µg/g F. TSF ranged between TF and IF. Most toothpastes were formulated with sodium fluoride (NaF), and only one with monofluorophosphate (MFP). The concentrations of TF were below the reported values. TSF and IF were below the TF concentration. CONCLUSIONS: The measured TF was less than that declared by the manufacturer in all the products. Most of the evaluated fluoride toothpastes commercialized in Brazil showed concentrations of TF below what was stated on the packaging, but with enough TSF to provide an anti-caries effect.
Dental Caries , Dentifrices , Child , Humans , Fluorides , Cariostatic Agents , Toothpastes , Brazil , Sodium Fluoride
To evaluate the fluoride concentration and pH of tea derived from Camellia sinensis produced and commercialized in Argentina. Forty-eight varieties of tea (black (n = 16), green (n = 21), red (n = 7), and white (n = 4)) commercialized in the form of leaves or tea bags were acquired. One bag or 2.0 ± 0.05 g of each product was infused for 5 min in 200 mL of distilled boiled water. The F- concentration was determined using an ion-selective electrode and pH was measured using a pH meter. The found fluoride concentrations ranged from 0.1 to 9.7 µg/mL and the pH ranged from 2.7 to 5.1. A higher fluoride concentration was observed in the leaves group (2.75 ± 2.65 µg/mL) compared to tea bags (1.10 ± 0.82 µg/mL) (p < 0.05). Regarding the type of tea, green and black tea were richer in F- than red and white tea. Fluoride and pH appeared not to be correlated (Pearson test). All the studied tea samples presented fluoride concentrations greater than the threshold recommended for drinking water. The pH proved to be low, which could be a risk for erosive tooth wear.
Camellia sinensis , Argentina , Environmental Monitoring , Fluorides/analysis , Tea
INTRODUCTION: Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. OBJECTIVE: This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. METHODS: This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments (p > 0.05). All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples (p > 0.05). RESULTS: The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. CONCLUSIONS: The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.
PURPOSE: This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. METHODS: A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. RESULTS: Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias. CONCLUSION: The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.
Dental caries is a sugar-dependent condition common in childhood, which causes microbiological imbalance in dental biofilm. The present study evaluated the antimicrobial efficacy of a 2.5% Brazilian Red Propolis (BRP) dental varnish to prevent caries in children. Seventy-five children with high caries risk, aged between 36 and 71 months and with no caries, were assigned to three groups to receive varnish treatment containing 2.5% BRP, 1% chlorhexidine, or 5% fluoride. The varnish was applied to the occlusal surfaces of the deciduous second molars on the first day of treatment (D1), after 90 days (D90), and 180 days of the start of treatment (D180). Saliva was collected to assess S. mutans before each varnish application and 180 days at the end of treatment (D360). Values were expressed in log10 (CFU/mL). Statistics were performed by applying repeated measures of variance analysis, Tukey's multiple comparisons test, and paired t-test. In the first dilution (1 : 10), there was microbial load reduction at the following periods: BRP in D0-D90 (p < 0.05) and D0-D180 (p < 0.01); fluoride in D0-D90 (p < 0.001); and chlorhexidine in D0-D180 (p < 0.05). In the second dilution (1 : 100), there was microbial load reduction in the groups at the following periods: BRP in D0-D90 (p < 0.05) and D0-D180 (p < 0.01); fluoride in D0-D180 (p < 0.05), and chlorhexidine in D0-180 (p < 0.01) and D0-360 (p < 0.05). The 2.5% BRP dental varnish was effective in decreasing S. mutans colonies in saliva when used within 90 days.
BACKGROUND: The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries.. METHODS: This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were carried out by ANOVA, Tukey's test, and the paired t-test. RESULTS: Copaiba varnish demonstrated significant S. mutans reduction: D360 versus D0 (p < 0.0001), D180 versus D0 (p < 0.001), D360 versus D90 (p < 0.001), D180 versus D90 (p < 0.001), and D360 versus D180 (p < 0.05). Chlorhexidine varnish significantly reduced S. mutans at D180 versus D0 (p < 0.05). Fluoride reduced at D180 versus D0 (p < 0.001). CONCLUSIONS: Three annual applications of this varnish showed substantial antimicrobial activity against S. mutans and caries prevention for up to 12 months.
BACKGROUND: Argentina has progressed with industrialization in comparison to other Latin American countries and this process had a direct impact on the innovative capacity of the national economy. A constant search for market leadership, including the dentistry field and dental materials, stimulates the industries to launch new products daily. Inventions related to health researches are mostly protected by patents as intellectual property. A patent landscape analysis through searches in patent banks is a tool used to identify trends in different areas of innovations. OBJECTIVE: This study aims to identify and evaluate the scenario of research, development and innovation of dental products in Argentina by a technological prospecting based on patents. METHODS: A survey of patent documents was conducted by searching for deposited and granted patents of dental products. The search was carried out during January 2020 in the patent database of the National Institute of Industrial Property of Argentina (INPI-AR). The terms "dentistry", "buccal", "dental" and "oral" were used to select the titles and abstracts of patent application reports. The information extracted from patent reports was organized in tables and Figs using Fig.Pad Prism 6 software to evaluate the applications. RESULTS: A total of 363 patents were published from 1989 to 2016, mainly by international industries, 93.3% as patent invention and 3.0% as utility model applications on dentistry. Only two patents (0.5%) were deposited by universities, as the University of Melbourne (Patent number 20060102378) and Universidad Nacional del Nordeste (Patent number 20140104149), among which only the last one is national. Among the deposits, only 6.6% were granted; mostly were in force, denied or lost. According to the specialties, most patents were related to compositions (64.7%) and personal products (21.7%), also on dentistry/cariology (6.33%) and prostheses/implants (4.68%). CONCLUSION: In general, we find that most patent applications are related to the preventive area, personal products and compositions for formulations. Few dental patents deposits are currently available in Argentina, suggesting that the importation of products into the area remains large, which can make dental products more expensive. It is important to invest in technology-based companies to promote increased economic activity, being a consequence of an investment in knowledge creation and intellectual property to the Dentistry area.
Intellectual Property , Patents as Topic , Argentina , Inventions , Technology
AIM: To evaluate the efficacy of dentifrice containing brazilian red propolis (BRP) in adolescents under orthodontic treatment. Materials and Methods. This is a randomized, double-blind, clinical trial. A total of 92 participants free from caries were randomized into 2 groups; the first received fluoride dentifrice, and the second received fluoride dentifrice incorporated with BRP. The gingival bleeding index (GBI) was recorded, and saliva was collected on the baseline (D0) and after 28 days (D28) for microbiological analysis. Data from GBI and Colony Forming Units (CFU) (log10) were expressed as mean and standard deviation. RESULTS: The two groups reduced GBI significantly, with no difference in the intergroup analysis. In the intragroup analysis, it was observed that G2 (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (S. mutans bacteria, it was observed that only G2 had a statistically significant reduction (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (p < 0.001) had a significant reduction for Gram-negative bacteria, while there was significance (. CONCLUSIONS: Dentifrice containing BRP demonstrated better clinical and microbiological activity. Future studies are needed to better identify effects to establish the use of dentifrice containing propolis in biofilm control.
BACKGROUND: Copaiba oil-resin has been widely used and is especially found in neotropical regions, for which several pharmacological activities have been documented over the years. Prospective studies in intellectual property banks are important to increase competitiveness and thus generate new products in various research areas. OBJECTIVE: A prospective study was carried out on patents of products containing copaiba oil-resin for dental use in intellectual property banks. METHODS: The research was conducted with patent searches in six intellectual property banks of the world. Relevant information about the invention in the patent document was collected, processed and described. RESULTS: The search found 9 patents using copaiba resin oil-resin in dental products. The National Institute of Industrial Property (INPI-Brazil) had the highest number of deposits (5), followed by Espacenet (2) and Free Patents (2). C. Langsdorffii was highlighted as the most widely used species in the products and deposits of vehicles in formulations (3). All the patents in the search are A61K code for medical, dental or hygienic purposes. CONCLUSION: Most of the found patents are related to the area of Microbiology, specifically with application in Cariology. Brazil is represented by the INPI and presented the highest number of patent applications when compared to other intellectual property banks.
Fabaceae , Oils, Volatile , Patents as Topic/statistics & numerical data , Plant Oils , Resins, Synthetic , Intellectual Property , Prospective Studies
O sucesso da reabilitação com implantes dentários está associado diretamente à quantidade e qualidade do tecido ósseo presente, favorecendo ou não o tratamento. A atrofia óssea dos maxilares, principalmente quando localizada nos rebordos alveolares, dificulta ou impede a reabilitação do aparelho estomatognático com o uso de implantes osseointegráveis. Na Odontologia, o plasma rico em plaquetas tem sido bastante estudado, sendo utilizado principalmente em cirurgias periodontais, cirurgias maxilofaciais e em pequenos enxertos ósseos em região alveolar para posterior colocação de implantes dentários. Diante disso, o objetivo do presente estudo foi realizar uma revisão de literatura sobre o plasma rico em plaquetas, abordando sua importância na Implantodontia, assim como sua obtenção e manipulação, características do material e indicações de aplicação. Muitos estudos demonstram as vantagens biológicas do plasma rico em plaquetas na reparação óssea em aplicações na clínica médica e odontológica. Esse biomaterial é uma alternativa viável, eficaz e de baixo custo relativo útil para acelerar os processos cicatriciais em tecidos moles e duros, podendo ser utilizado de forma isolada ou associado a outro biomaterial (AU).
The success of rehabilitation with dental implants is directly associated to the quantity and quality of bone tissue, favoring the treatment or not. The maxillary bone atrophy, especially when located in the alveolar ridges, obstructs or impedes the rehabilitation of the stomatognathic system with the use of dental implants. In Dentistry, the platelet-rich plasma has been studied extensively, being used especially in periodontal surgery, maxillofacial surgery, and small bone grafts in alveolar region for later placement of dental implants. Therefore, the aim of this study was to review the literature about the platelet-rich plasma, addressing its importance in Implantology, as well as obtaining and handling, characteristics of the material and directions for applying it. Many studies demonstrate the biological benefits of plateletrich plasma on bone healing in applications in medical and dental clinic. This biomaterial is a viable, effective and relatively low-cost useful alternative for speeding up the healing process in soft and hard tissues, and may be used alone or associated with another biomaterial (AU).
Biocompatible Materials , Dental Implants , Platelet-Rich Plasma , Mouth Rehabilitation , Brazil , Review
Para a reconstrução de dentes anteriores que sofreram fraturas ou restaurações envolvendo o ângulo incisal, a Dentística dispõe de um tratamento que oferece a cópia ideal da estrutura palatina, a técnica de restauração usando a muralha de silicona. Esta técnica permite recuperar a estética de forma rápida, conservadora e oferece uma grande vantagem para a Odontopediatria como a redução do tempo de cadeira do paciente infantil. O objetivo do presente trabalho foi relatar um caso em que foi aplicada a técnica da muralha de silicona em paciente pediátrico. Paciente CIG, gênero masculino, 8 anos de idade, apresentando fratura oblíqua das coroas dos dentes 11 e 21. Após procedimentos emergenciais, o paciente teve suas arcadas moldadas e posterior moldagem de gesso, reconstrução em cera, confecção da muralha e restauração dos dentes fraturados. O caso foi solucionado apenas com recursos de Dentística, técnica da muralha, utilização de ceroplastia e resinas compostas fotopolimerizáveis, alcançando-se um bom resultado estético. Portanto, conclui-se que a confecção da técnica da muralha de silicona para restauração direta em dentes anteriores traz vantagens no tempo gasto para realização do procedimento clínico, além de resultado satisfatório e estético.
For the reconstruction of fractured anterior teeth or restorations involving the incisal angle, the silicone guide technique offers an ideal copy of the palatal structure. This technique allows a fast and conservative aesthetics restoration, as well as reduces chair time, an important advantage at odontopediatric procedures. The aim of this study was to report a case in which the silicone guide technique was applied at the treatment of a pediatric patient. CIG, male patient 8 years old, presenting oblique fracture on crowns of teeth #11 #21. After emergency procedures, dental impressions from the patient were taken and a cast model was made, followed by the wax-up. Then silicone wall was manufactured and teeth were restored. The case was solved using just dentistry resources such as the guide technique, wax-up, and light cured composite resins and has achieved satisfactory results. Therefore, it was concluded that the silicone guide technique applied to direct restoration in anterior teeth has the advantage of reduced chair time obtaining satisfactory aesthetic results.
Humans , Male , Child , Child , Esthetics, Dental , Pediatric Dentistry , Silicones , Tooth Injuries
Objetiva-se nesse artigo realizar um levantamento na literatura sobre a associação entre o uso de chupetas na prevenção de morte súbita em crianças. Foi realizada uma revisão de literatura e escolhidos 34 artigos publicados entre os anos de 1978 e 2012 em bancos de dados como PubMed e Scielo, usando os descritores: "morte súbita", "chupetas" e "SIDS". À medida que a mortalidade infantil vem sendo reduzida devido às melhorias socioeconômicas, ambientais e na assistência médica, as mortes súbitas na infância (MSI) tendem a assumir papel relativamente mais importante. Concluiu-se que, de acordo com a literatura, o uso de chupeta por lactentes vem reduzindo consideravelmente a incidência de morte súbita dos mesmos (AU)
The aim of this study was to present a literature review about the use of pacifiers use in the prevention of sudden infant death. A search was conducted in PubMed and SciELO, for studies published between 1978 and 2012 using the key words: "sudden death", "pacifiers", and "SIDS". Thirty four studies were selected. As infant mortality has been reduced due to socioeconomics and environmental improvements, as well as to better medical care, there is a tendency to dedicate greater attention to the sudden infant death syndrome (SIDS). It was concluded that according to the literature the use of pacifiers may reduce considerably the incidence of sudden death of them (AU)
Humans , Infant, Newborn , Infant , Infant , Pacifiers/statistics & numerical data , Sleep , Sudden Infant Death , Brazil , Review , Risk Factors , Sucking Behavior
Introduction:The global increase life expectancy and the resulting tooth loss has required searching for new rehabilitation alternatives in Dentistry. Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. Objective: To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. Material and methods: The following databases were searched: Pubmed, Bireme, Lilacs, and Scielo and 30 articles published between 1965 and 2013 were found using the following descriptors: "dental implants", "maxillary sinus", and "biocompatible materials". Results: Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. In recent years, morphogenetic protein has presented a large clinical use. Conclusion: Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face.
Objetivo: avaliar o perfil epidemiológico dos usuários intensivos de um Centro de Atenção Psicossocial. Método: estudo descritivo quantitativo, de base documental, nos prontuários de pessoas atendidas de forma intensiva no período de maio a julho de 2010 no Centro de Assistência Psicossocial da Secretaria Executiva Regional VI do município de Fortaleza-Ceará. Os dados foram analisados no Programa IBM SPSS Statistics 20 apresentados em tabelas. O projeto de pesquisa foi aprovado pelo Comitê de Ética em Pesquisa, Parecer de nº 10029576-2. Resultados: foram analisados 35 prontuários de pacientes intensivos, observou-se que o gênero feminino predominou, principalmente de escolaridade e renda baixas. Entre as queixas de sintomatologia predominaram as alucinações auditivas, quanto às patologias predominou o transtorno de humor. Conclusão: as políticas públicas de saúde mental de Fortaleza devem atuar no sentido de atender as necessidades de mudanças no CAPS. (AU)
Objective: evaluating the epidemiological profile of intensive users of a Psychosocial Care Center. Method: a quantitative descriptive study, of a document basis, in the records of people seen intensively in the period from May to July 2010 in the Psychosocial Assistance Center in Regional Executive Secretary VI in FortalezaCeara. Data were analyzed in IBM SPSS Statistics 20 presented in tables. The research project was approved by the Research Ethics Committee, Opinion nº 10029576-2. Results: there were analyzed 35 medical records of intensive patients, observing that females predominated, with low education and income. Among the complaints of symptoms predominated auditory hallucinations, regarding the diseases predominated mood disorder. Conclusion: the public policies of mental health in Fortaleza should act to meeting the needs of changes in CAPS. (AU)
Objetivo: evaluar el perfil epidemiológico de los usuarios intensivos de un Centro de Atención Psicosocial. Método: un estudio descriptivo cuantitativo, de base de documental, en los registros de personas atendidas intensamente en el período mayo-julio, 2010, en el Centro de Asistencia Psicosocial de la Secretaria Ejecutiva Regional VI en Fortaleza-Ceará. Se analizaron los datos en IBM SPSS Statistics 20 presentados en tablas. El proyecto de investigación fue aprobado por el Comité de Ética en la Investigación, Opinión nº 10029576-2. Resultados: eran analizados 35 prontuarios de pacientes intensivos, se observó que las mujeres predominaban, principalmente de baja educación y bajos ingresos. Entre los síntomas de quejas predominan las alucinaciones auditivas, para las enfermedades predominó el trastorno de humor. Conclusión: las políticas públicas de salud mental de Fortaleza deben actuar para satisfacer las necesidades de cambios en el CAPS. (AU)
Humans , Male , Female , Adult , Middle Aged , Health Profile , Mental Health Services , Mental Health , Epidemiology , Depression
Introduction: Temporomandibular disorder (TMD) is the term used in Dentistry to define the structural and disorder changes affect the physiology of the masticatory system composed of TMJ and related to musculoskeletal structures. Objective: To conduct a descriptive, transversal and documentary study aiming to determine the profile of 14 TMD patients undergoing simultaneous dental and physiotherapeutic treatment at a private practice of the city of Fortaleza-Ce. Material and methods: The following instruments for the collection of the data were employed: files registering the evaluation and evolution, findings of the radiographic examinations and forms. Data were statistically analyzed through SPSS software, version 10.0. Results: Most of the sample was composed by females aged 32 years (+/-10.60) in average, mainly complaining about chronic headache, masticatory myalgia , TMJ pain, cervicalgy, otalgia, among others. The complete sample presented, at least, one pathology associated to and/or concomitant to TMD. The radiographic findings showed TMJ alterations and tooth losses. Analgesics were the most used drugs. Conclusion: TMD is a complex syndrome, with many etiologies and symptoms, aggravating and perpetuating factors, requiring multiple and even more specialized therapeutic management attempting treatment success.
