TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer: a clinical next-generation sequencing study.

Background: TP53 mutations and homologous recombination deficiency (HRD) occur frequently in breast cancer. However, the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not clear. Methods: Clinical next-generation sequencing (NGS) of both tumor and paired blood DNA from 119 breast cancer patients (BRCA-119 cohort) was performed with a 520-gene panel. Mutations, tumor mutation burden (TMB), and genomic HRD scores were assessed from NGS data. NGS data from 47 breast cancer patients in the HRD test cohort were analyzed for further verification. Results: All TP53 pathogenic mutations in patients had somatic origin, which was associated with the protein expression of estrogen receptor and progestogen receptor. Compared to patients without TP53 pathologic mutations, patients with TP53 pathologic mutations had higher levels of HRD scores and different genomic alterations. The frequency of TP53 pathologic mutation was higher in the HRD-high group (HRD score ≥ 42) relative to that in the HRD-low group (HRD score < 42). TP53 has different mutational characteristics between the HRD-low and HRD-high groups. TP53-specific mutation subgroups had diverse genomic features and TMB. Notably, TP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve (AUC) of 0.61. TP53-specific mutations, namely HRD-low mutation, HRD-high mutation, and HRD common mutation, predicted the HRD status of breast cancer patients with AUC values of 0.32, 0.72, and 0.58, respectively. Interestingly, TP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values (0.80) in predicting HRD status. Conclusions: TP53-specific mutation combinations predict the HRD status of patients, indicating that TP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase (PARP) inhibitors in breast cancer patients .

Hybrid supercapacitors using metal-organic framework derived nickel-sulfur compounds.

HYPOTHESIS: Metal-organic frameworks (MOFs) are highly suitable precursors for supercapacitor electrode materials owing to their high porosity and stable backbone structures that offer several advantages for redox reactions and rapid ion transport. EXPERIMENTS: In this study, a carbon-coated Ni9S8 composite (Ni9S8@C-5) was prepared via sulfuration at 500 ℃ using a spherical Ni-MOF as the sacrificial template. FINDING: The stable carbon skeleton derived from Ni-MOF and positive structure-activity relationship due to the multinuclear Ni9S8 components resulted in a specific capacity of 278.06 mAh·g-1 at 1 A·g-1. Additionally, the hybrid supercapacitor (HSC) constructed using Ni9S8@C-5 as the positive electrode and the laboratory-prepared coal pitch-based activated carbon (CTP-AC) as the negative electrode achieved an energy density of 69.32 Wh·kg-1 at a power density of 800.06 W·kg-1, and capacity retention of 83.06 % after 5000 cycles of charging and discharging at 5 A·g-1. The Ni-MOF sacrificial template method proposed in this study effectively addresses the challenges associated with structural collapse and agglomeration of Ni9S8 during electrochemical reactions, thus improving its electrochemical performance. Hence, a simple preparation method is demonstrated, with broad application prospects in supercapacitor electrodes.

The ordered lattice host framework induced guest Li+ disordering in high performance cobalt-free Ni-rich cathode materials.

Recently, due to high price, resource shortage and unstable supply of cobalt, the development of low-cost cobalt-free Ni-rich cathodes has attracted extensive attention with the ever-increasing lithium-ion batteries (LIBs) industry. Selecting cost-effective elements to replace cobalt in Ni-rich cathodes is urgent. However, the principle of structural design of Ni-rich cathode remains unclear, hampering the selection of alternative elements. Herein, the cobalt-free cathodes of LiNi0.95Mg0.05O2 (NiMg) and LiNi0.95Mn0.05O2 (NiMn) are designed as alternatives to LiNi0.96Co0.04O2 (NiCo). NiMg has comparable cycle stability with NiCo, while NiMn has inferior cycle performance. Reverse Monte Carlo modelling was used to generate structural model and uncover local structure by fitting pair distribution function. It reveals Mn causes more severe Jahn-Teller distortions and disordered lattice host framework (Ni0.95M0.05O2, M = Co/Mn/Mg) than Co and Mg due to the strong size effect and coulomb interactions of Mn in Ni0.95Mn0.05O2 layer. The outstanding cycle stability of NiMg and NiCo originates from the ordered lattice host frameworks, which relieve stress and inhibit particle breakage during cycle. Meanwhile, the ordered lattice host framework induced guest Li+ disordering reduces Li+ diffusion energy barrier, improving the rate capability. This study provides a new perspective for the structural design of cobalt-free Ni-rich cathodes.

Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real-world clinical tumor sequencing study.

Breast cancers involving mutations in homologous recombination (HR) genes, most commonly BRCA1 and BRCA2 (BRCA1/2), respond well to PARP inhibitors and platinum-based chemotherapy. However, except for these specific HR genes, it is not clear which other mutations contribute to homologous recombination defects (HRD). Here, we performed next-generation sequencing of tumor tissues and matched blood samples from 119 breast cancer patients using the OncoScreen Plus panel. Genomic mutation characteristics and HRD scores were analyzed. In the HR genes, we found that BRCA1/2 and PLAB2 mutations were related to HRD. HRD was also detected in a subset of patients without germline or somatic mutations in BRCA1/2, PLAB2, or other HR-related genes. Notably, LRP1B, NOTCH3, GATA2, and CARD11 (abbreviated as LNGC) mutations were associated with high HRD scores in breast cancer patients. Furthermore, functional experiments demonstrated that silencing CARD11 and GATA2 impairs HR repair efficiency and enhances the sensitivity of tumor cells to olaparib treatment. In summary, in the absence of mutations in the HR genes, the sensitivity of tumor cells to PARP inhibitors and platinum-based chemotherapy may be enhanced in a subset of breast cancer patients with LNGC somatic mutations.

Construction of hub transcription factor-microRNAs-messenger RNA regulatory network in recurrent implantation failure.

PURPOSE: Recurrent implantation failure (RIF) affects up to 10% of in vitro fertilization (IVF) patients worldwide. However, the pathogenesis of RIF remains unclear. This study was aimed at identifying hub transcription factors (TFs) of RIF in bioinformatics approaches. METHODS: The GSE111974 (mRNA), GSE71332 (miRNA), and GSE103465 (mRNA) datasets were downloaded from the Gene Expression Omnibus database from human endometrial tissue using R version 4.2.1 and used to identify differentially expressed TFs (DETFs), differentially expressed miRNAs, and differentially expressed genes for RIF, respectively. DETFs were subjected to functional enrichment analysis and the protein-protein interaction network analysis using the Search Tool for the Retrieval of Interacting Genes (version 11.5) database. Hub TFs were identified using the cytoHubb plug-in, after which a hub TF-miRNA-mRNA network was constructed using Cytoscape v3.8.2. RESULTS: Fifty-seven DETFs were identified, in which Gene Ontology analysis revealed to be mainly involved in the regulation of transcription. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that DETFs were enriched in transcriptional misregulation in cancer, aldosterone synthesis and secretion, AMPK signaling pathway, and cGMP-PKG signaling pathway. EOMES, NKX2-1, and POU5F1 were identified as hub TFs, and a hub TF-miRNA-mRNA regulatory network was constructed using these three hub TFs, four miRNAs, and four genes. CONCLUSION: Collectively, we identified three promising molecular biomarkers for the diagnosis of RIF, which may further be potential therapeutic targets. This study provides novel insights into the molecular mechanisms underlying RIF. However, further experiments are required to verify these results.

Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells.

AIM: Vitamin D3 has been implicated in multiple reproductive events, whereas the effect of its bioactive metabolite 1α, 25 dihydroxyvitamin D3 (1,25(OH) 2 D3 ) on transcriptome profile of the placenta is unclear. The aim of this article is to determine transcriptome-wide profile caused by 1,25(OH) 2 D3 in human placental trophoblast cells. METHODS: We performed RNA sequencing after stimulation of HTR-8/SVneo cells with 0.1, 1, 10, and 100 nM 1,25(OH)2 D3 for 24 h, identified differentially expressed genes by edgeR package (version 3.38.4), and analyzed Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways by webtool Metascape. Also, common genes and specific genes in different concentrations of 1,25(OH) 2 D3 were identified. RESULTS: There were 180, 158, 161, and 174 differentially expressed genes after 0.1, 1, 10, and 100 nM 1,25(OH) 2 D3 stimulation, respectively. KEGG pathway analysis displayed that "lipid and atherosclerosis" were significantly enriched at 0.1 and 1 nM 1,25(OH)2 D3 , while "cytokine-cytokine receptor interaction," "TGF-beta signaling pathway" and "hippo signaling pathway" were significantly enriched in 1, 10, and 100 nM 1,25(OH)2 D3 . CYP24A1 was a significantly expressed common gene. UCP3 was significantly expressed in low concentrations and might affect energy metabolism. TCF24, EIF3CL, ABCD2, EPHA7, CRLF1, and SECTM1 were specific genes at physiological concentration. Similarly, SPDYE1, IQUB, IL18R1, and ZNF713 were considered as specific genes at supraphysiological concentration. CONCLUSIONS: 1,25(OH)2 D3 mainly affected the expression of CYP24A1 gene in HTR-8/SVneo cells. Specific genes accounted for the majority of differentially expressed genes at different concentrations. However, their functions need to be further confirmed.

Chelated Ion-Exchange Strategy toward BiOCl Mesoporous Single-Crystalline Nanosheets for Boosting Photocatalytic Selective Aromatic Alcohols Oxidation.

The photoresponse and photocatalytic efficiency of bismuth oxychloride (BiOCl) are greatly limited by rapid recombination of photogenerated carriers. The construction of porous single-crystal BiOCl photocatalyst can effectively alleviate this issue and provide accessible active sites. Herein, a facile chelated ion-exchange strategy is developed to synthesize BiOCl mesoporous single-crystalline nanosheets (BiOCl MSCN) using acetic acid and ammonia solution respectively as chelating agent and ionization promoter. The strong chelation between acetate ions and Bi3+ ions introduces acetate ions into the precipitated product to exchange with Cl- ions, resulting in large lattice mismatch, strain release, and formation of void-like mesopores. The prepared BiOCl MSCN photocatalyst exhibits excellent catalytic performance with 99% conversion and 98% selectivity for oxidation of benzyl alcohol to benzaldehyde and superior general adaptability for various aromatic alcohols. The theoretical calculations and characterizations confirm that the superior performance is mainly attributed to the abundant oxygen vacancies, plenty of accessible adsorption/active sites and fast charge transport path without grain boundaries.

Exploring and attributing change to fractional vegetation coverage in the middle and lower reaches of Hanjiang River Basin, China.

The middle and lower reaches of Hanjiang River Basin (MLHB), areas that have an important ecological function in China, have experienced great changes in the vegetation ecosystem driven by natural environmental change and human activity. Here, we explored the spatio-temporal dynamics of fractional vegetation coverage (FVC) and quantitatively analyzed its driving factors to advance current understanding of how the ecological environment has changed. Specifically, we used the dimidiate pixel model to calculate the FVC of the MLHB from 2001 to 2018 based on Moderate Resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) data. We then used Theil-Sen median slope (Sen's slope) and coefficient of variation (CV) to explore spatial and temporal variations, as well as characteristics in fluctuations. Finally, we utilized a geographical detector model (with spatial scale effects and spatial data discretization tests) to quantify the influence of the detected natural and human factors. Results showed that average annual FVC was 0.30-0.75 for ~90% of the study area over the 19-year study period with a heterogeneous spatial distribution. FVC variation trend displayed stability and improvement. Areas with higher FVC displayed greater stability. All 10 detected natural and anthropogenic factors were responsible for changes in FVC. The primary factors causing FVC to change were precipitation (in 2001) and slope (in 2018), followed by landform type, distance to water, and nighttime light (NTL) (in 2018). Precipitation and slope consistently displayed the largest interaction across all years. The interaction between human and topographical factors had gradually increasing significance on changes in FVC over the research period. The range and type of factors suitable for promoting vegetation growth were detected in the study area. Results of this study can provide a scientific basis for developing effective strategies for local vegetation protection, restoration, and land resource management.

Ni-soc-MOF derived carbon hollow sphere encapsulated Ni3Se4 nanocrystals for high-rate supercapacitors.

Carbon hollow sphere encapsulated Ni3Se4 (Ni3Se4@CHS) nanocrystals are prepared using the Ni-soc-MOF by pyrolysis and further selenization. Ni3Se4@CHS exhibits a capacitance of 1720 F g-1 at 1 A g-1 and a capacitance retention of 97% after 6000 cycles at 5 A g-1. Moreover, the asymmetric supercapacitor of Ni3Se4@CHS//AC displays a wide potential window of 1.6 V, an energy density of 45.2 W h kg-1 at a power density of 800 W kg-1, and excellent cycling stability (89% capacitance retention) after 5000 cycles. Overall, this work establishes a significant step to synthesize a new carbon-based material with appreciable capacitance and long cycling durability for potential applications in energy storage and beyond.

Tetrakaidecahedron-shaped Cu four-core supramolecule as novel high-performance electrode material for lithium-ion batteries.

Here, a tetrakaidecahedron-shaped Cu four-core supramolecule was designed to overcome the defects of supramolecules for lithium-ion batteries. With multiple metal centers, conductive ligands and abundant hydrogen bonds, this novel electrode shows excellent rate capability (459.4 mA h g-1 at 2000 mA g-1) and cyclicality (494.5 mA h g-1 after 700 cycles).

Ethnobotanical survey of antifertility medicinal plants in Dali District, Yunnan Province, China.

In recent years, contraceptive medication has been widely used for birth control. It is worth noting that contraceptive medication from botanical source has great potential for clinical use. Yunnan is the province with the most species of plants in China and is known as the "plant kingdom". This study aims to archive herbal remedies traditionally used as antifertility remedies in Dali District, Yunnan Province, P. R. China. The survey was conducted from February 2011 to September 2016 in the population distributed in Dali and the surrounding counties. The data were collected from three groups of practitioners within the study area: therapists using traditional medicines (n = 104), aboriginal families (n = 37), and herbalists in commercial stalls (n = 12), and a total number of 117 plant species were recorded. Among the 117 plant species, 104 of which have been authenticated by a plant taxonomist from the Dali Herbarium. These plants were classified into 98 genera and 54 families, including Leguminosae (12 species), Liliaceae (7 species), Cucurbitaceae, Rosaceae and Rutaceae (5 species, respectively), Malvaceae, Compositae and Euphorbiaceae (4 species, respectively). Our data provides an in-depth delineation of the contraceptive plants used in Dali, which serve as valuable information for the practitioners of traditional Chinese medicine in contraceptive use. In addition, these data also hint that plants from different genus contain contraceptive components, which should be avoided by pregnant women. Future studies are required to identify the active contraceptive components, assess the toxicology, and elucidate the pharmacological mechanism of action.

Application of Metabolomics to the Discovery of Biomarkers for Ischemic Stroke in the Murine Model: a Comparison with the Clinical Results.

Ischemic stroke (IS) is a major cause of mortality and disability worldwide. However, the pathogenesis of IS remains unknown, and methods for early prediction and diagnosis of IS are lacking. Metabolomics can be applied to biomarker discovery and mechanism exploration of IS by exploring metabolic alterations. In this review, 62 IS metabolomics studies in the murine model published from January 2006 to December 2020 in the PubMed and Web of Science databases were systematically reviewed. Twenty metabolites (e.g., lysine, phenylalanine, methionine, tryptophan, leucine, lactate, serine, N-acetyl-aspartic acid, and glutathione) were reported consistently in more than two-third murine studies. The disturbance of metabolic pathways, such as arginine biosynthesis; alanine, aspartate and glutamate metabolism; aminoacyl-tRNA biosynthesis; and citrate cycle, may be implicated in the development of IS by influencing the biological processes such as energy failure, oxidative stress, apoptosis, and glutamate toxicity. The transient middle cerebral artery occlusion model and permanent middle cerebral artery occlusion model exhibit both common and distinct metabolic patterns. Furthermore, five metabolites (proline, serine, LysoPC (16:0), uric acid, glutamate) in the blood sample and 7 metabolic pathways (e.g., alanine, aspartate, and glutamate metabolism) are shared in animal and clinical studies. The potential biomarkers and related pathways of IS in the murine model may facilitate the biomarker discovery for early diagnosis of IS and the development of novel therapeutic targets.

Regulative Electronic States around Ruthenium/Ruthenium Disulphide Heterointerfaces for Efficient Water Splitting in Acidic Media.

Theoretical calculations unveil the charge redistribution over abundant interfaces and the enhanced electronic states of Ru/RuS2 heterostructure. The resulting surface electron-deficient Ru sites display optimized adsorption behavior toward diverse reaction intermediates, thereby reducing the thermodynamic energy barriers. Experimentally, for the first time the laminar Ru/RuS2 heterostructure is rationally engineered by virtue of the synchronous reduction and sulfurization under eutectic salt system. Impressively, it exhibits extremely high catalytic activity for both OER (201 mV @ 10 mA cm-2 ) and HER (45 mV @ 10 mA cm-2 ) in acidic media due to favorable kinetics and excellent specific activity, consequently leading to a terrific performance in acidic overall water splitting devices (1.501 V @ 10 mA cm-2 ). The in-depth insight into the internal activity origin of interfacial effect could offer precise guidance for the rational establishment of hybrid interfaces.

Construction of Circular RNA-MicroRNA-Messenger RNA Regulatory Network of Recurrent Implantation Failure to Explore Its Potential Pathogenesis.

Background: Many studies on circular RNAs (circRNAs) have recently been published. However, the function of circRNAs in recurrent implantation failure (RIF) is unknown and remains to be explored. This study aims to determine the regulatory mechanisms of circRNAs in RIF. Methods: Microarray data of RIF circRNA (GSE147442), microRNA (miRNA; GSE71332), and messenger RNA (mRNA; GSE103465) were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed circRNA, miRNA, and mRNA. The circRNA-miRNA-mRNA network was constructed by Cytoscape 3.8.0 software, then the protein-protein interaction (PPI) network was constructed by STRING database, and the hub genes were identified by cytoHubba plug-in. The circRNA-miRNA-hub gene regulatory subnetwork was formed to understand the regulatory axis of hub genes in RIF. Finally, the Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the hub genes were performed by clusterProfiler package of Rstudio software, and Reactome Functional Interaction (FI) plug-in was used for reactome analysis to comprehensively analyze the mechanism of hub genes in RIF. Results: A total of eight upregulated differentially expressed circRNAs (DECs), five downregulated DECs, 56 downregulated differentially expressed miRNAs (DEmiRs), 104 upregulated DEmiRs, 429 upregulated differentially expressed genes (DEGs), and 1,067 downregulated DEGs were identified regarding RIF. The miRNA response elements of 13 DECs were then predicted. Seven overlapping miRNAs were obtained by intersecting the predicted miRNA and DEmiRs. Then, 56 overlapping mRNAs were obtained by intersecting the predicted target mRNAs of seven miRNAs with 1,496 DEGs. The circRNA-miRNA-mRNA network and PPI network were constructed through six circRNAs, seven miRNAs, and 56 mRNAs; and four hub genes (YWHAZ, JAK2, MYH9, and RAP2C) were identified. The circRNA-miRNA-hub gene regulatory subnetwork with nine regulatory axes was formed in RIF. Functional enrichment analysis and reactome analysis showed that these four hub genes were closely related to the biological functions and pathways of RIF. Conclusion: The results of this study provide further understanding of the potential pathogenesis from the perspective of circRNA-related competitive endogenous RNA network in RIF.

Conductive Metal-Organic Frameworks for Amperometric Sensing of Paracetamol.

An electrochemical sensor for paracetamol is executed by using conductive MOF (NiCu-CAT), which is synthesized by 2, 3, 6, 7, 10, 11-hexahydroxytriphenylene (HHTP) ligand. The utility of this 2D NiCu-CAT is measured by the detection of paracetamol, p-stacking within the MOF layers is essential to achieve high electrical conductivity, redox activity, and catalytic activity. In particular, NiCu-CAT demonstrated detection Limit of determination near 5µM for paracetamol through a wide concentration range (5-190 µM). The NiCu-CAT/GCE exhibits excellent reproducibility, stability, and interference for paracetamol.

New P2-Type Honeycomb-Layered Sodium-Ion Conductor: Na2Mg2TeO6.

A novel solid sodium-ion conductor, Na2Mg2TeO6 (NMTO) with a P2-type honeycomb-layered structure, has been synthesized for the first time by a simple solid-state synthetic route. The conductor of NMTO exhibits high conductivity of 2.3 × 10-4 S cm-1 at room temperature (RT) and a large electrochemical window of ∼4.2 V (versus Na+/Na). The conductor is remarkably stable, both in the ambient environment and within its metallic Na anode. This facile sodium-ion conductor displays potential for use in all-solid-state sodium-ion batteries (SS-SIBs).

A P2-Type Layered Superionic Conductor Ga-Doped Na2 Zn2 TeO6 for All-Solid-State Sodium-Ion Batteries.

Here, a P2-type layered Na2 Zn2 TeO6 (NZTO) is reported with a high Na+ ion conductivity ≈0.6×10-3  S cm-1 at room temperature (RT), which is comparable to the currently best Na1+n Zr2 Sin P3-n O12 NASICON structure. As small amounts of Ga3+ substitutes for Zn2+ , more Na+ vacancies are introduced in the interlayer gaps, which greatly reduces strong Na+ -Na+ coulomb interactions. Ga-substituted NZTO exhibits a superionic conductivity of ≈1.1×10-3  S cm-1 at RT, and excellent phase and electrochemical stability. All solid-state batteries have been successfully assembled with a capacity of ≈70 mAh g-1 over 10 cycles with a rate of 0.2 C at 80 °C. 23 Na nuclear magnetic resonance (NMR) studies on powder samples show intra-grain (bulk) diffusion coefficients DNMR on the order of 12.35×10-12  m2 s-1 at 65 °C that corresponds to a conductivity σNMR of 8.16×10-3  S cm-1 , assuming the Nernst-Einstein equation, which thus suggests a new perspective of fast Na+ ion conductor for advanced sodium ion batteries.

Graphene-Roll-Wrapped Prussian Blue Nanospheres as a High-Performance Binder-Free Cathode for Sodium-Ion Batteries.

Sodium iron hexacyanoferrate (Fe-HCF) has been proposed as a promising cathode material for sodium-ion batteries (SIBs) because of its desirable advantages, including high theoretical capacity (∼170 mAh g-1), eco-friendliness, and low cost of worldwide rich sodium and iron resources. Nonetheless, its application faces a number of obstacles due to poor electronic conductivity and structural instability. In this work, Fe-HCF nanospheres (NSs) were first synthesized and fabricated by an in situ graphene rolls (GRs) wrapping method, forming a 1D tubular hierarchical structure of Fe-HCF NSs@GRs. GRs not only provide fast electronic conduction path for Fe-HCF NSs but also effectively prevent organic electrolyte from reaching active materials and inhibit the occurrence of side reactions. The Fe-HCF NSs@GRs composite has been used as a binder-free cathode with a capacity of ∼110 mAh g-1 at a current density of 150 mA g-1 (∼1C), the capacity retention of ∼90% after 500 cycles. Moreover, the Fe-HCF NSs@GRs cathode displays a super high rate capability with ∼95 mAh g-1 at 1500 mA g-1 (∼10C). The results suggest that the 1D tubular structure of 2D GRs-wrapped Fe-HCF NSs is promising as a high-performance cathode for SIBs.

Enhancing Sodium-Ion Storage Behaviors in TiNb2O7 by Mechanical Ball Milling.

Sodium-ion batteries (SIBs) have shown extensive prospects as alternative rechargeable batteries in large-scale energy storage systems, because of the abundance and low cost of sodium. The development of high-performance cathode and anode materials is a big challenge for SIBs. As is well known, TiNb2O7 (TNO) exhibits a high capacity of ∼250 mAh g-1 with excellent capacity retention as a Li-insertion anode for lithium-ion batteries, but it has rarely been discussed as an anode for SIBs. Here, we demonstrate ball-milled TiNb2O7 (BM-TNO) as an SIB anode, which provides an average voltage of ∼0.6 V and a reversible capacity of ∼180 mAh g-1 at a current density of 15 mA g-1, and presents excellent cyclability with 95% capacity retention after 500 cycles at 500 mA g-1. A possible Na storage mechanism in BM-TNO is also proposed.