RESUMEN
The present paper is designed to promote awareness of DCD outside the academic world. With a prevalence of 5-6% it is one of the most common disorders of child development. It is therefore surprising that so little is known about it among professionals in child healthcare and education. Parents have expressed frustration about this lack of awareness, including the general public. The general aim of this paper was to describe those critical aspects of DCD that will promote awareness.
Asunto(s)
Trastornos de la Destreza Motora , Niño , Humanos , Trastornos de la Destreza Motora/epidemiología , Desarrollo Infantil , Escolaridad , Padres , PrevalenciaRESUMEN
BACKGROUND: In everyday life, tasks are often performed simultaneously, which may be more difficult for children with developmental coordination disorder (DCD) than their peers. AIMS: To examine (1) the effects of task complexity and type of concurrent task on dual-task performance in children with and without DCD; and (2) if the amount of effort that children put into the task performance differs between the groups. METHODS: Participants were 64 children with and without DCD (aged 7-14 years). The dual-task paradigm consisted of a manual dexterity task of relatively low complexity (box and block test) or relatively high complexity (pegboard task), and a concurrent motor task (cycling task) or a concurrent cognitive task (word-listening task). To assess mental effort, children were asked how tired they felt before and after the experiment. RESULTS: Dual-task interference was highest when the manual dexterity task of relatively high complexity was combined with the concurrent motor task. There were no group differences in dual-task interference, but children with DCD reported a larger increase in the level of tiredness after the experiment indicative of greater mental effort. CONCLUSIONS: Depending on task demands, children with DCD are able to perform dual-tasks at the same level as their peers, but performance may take children with DCD more mental effort.
Asunto(s)
Trastornos de la Destreza Motora , Análisis y Desempeño de Tareas , Humanos , Niño , Trastornos de la Destreza Motora/psicología , Cognición , Destreza MotoraRESUMEN
BACKGROUND: When completing grip-selection tasks, healthy adults generally plan for the most comfortable end-posture which is termed the end-state comfort (ESC) effect. Children with and without developmental coordination disorder (DCD) are less likely to plan for ESC which begs the question as to whether they are not able to perform this type of planning or whether they prioritize other aspects of the task. AIMS: (1) Examine if children with and without probable DCD (pDCD) are able to plan for ESC if they are explicitly instructed to and (2) if this transfers to another similar task. (3) Examine if children with and without pDCD perceive the level of comfort of the grips that they use differently and if this relates to ESC planning. METHODS: Twelve children with and 12 children without probable DCD (pDCD) (aged 5-9 years) received a 10-min training session in which children were explicitly instructed to end their movement in ESC, after which they formulated their own plan to reach this goal. The study consisted of a pre-post-test design in which changes in the proportion of ESC were analyzed on the task that was trained as well as on an untrained transfer-task. Furthermore, the perceived level of comfort was examined. RESULTS: Both groups of children showed a higher proportion of ESC on the post-test compared with the pre-test, on the task that was trained as well as on the transfer-task. There were no group differences regarding the perceived level of comfort of the different grip postures. CONCLUSION: The majority of the children with and without pDCD seems to be able to adjust their planning strategy and prioritize ESC if they are explicitly instructed to.
Asunto(s)
Trastornos de la Destreza Motora , Adulto , Humanos , Niño , Objetivos , Movimiento , Postura , Fuerza de la ManoRESUMEN
AIM: To identify subtypes in a large group of children clinically diagnosed with developmental coordination disorder (DCD) based on their pattern of motor, cognitive, and visual-motor abilities. METHOD: Standardized scores for verbal IQ, total IQ, Movement Assessment Battery for Children, Second Edition (MABC-2) balance, MABC-2 manual dexterity, MABC-2 ball skills, and Beery-Buktenica Developmental Tests of Visual-Motor Integration (Beery-VMI), Motor Coordination (Beery-MC), and Visual Perception (Beery-VP) were used. The NbClust complete procedure was used to best partition the data on 98 children (84 males, 14 females, mean [SD] age: 8 years [2 years 1 month]) into clusters. Deviation contrasts, multivariate analysis of variance, and post hoc comparisons were used to characterize the clusters. RESULTS: Four clusters were revealed: two clusters with a broad motor skill problem, one with relatively preserved visual-motor integration and Beery-MC skills, and a second with abnormal ball skills, balance, and Beery-MC skills. A third cluster with more specific gross-motor problems, and a fourth with relatively preserved ball skills but low Beery-MC and performance IQ, were identified. Balance scores were 'at risk' or 'abnormal' in all four clusters. INTERPRETATION: DCD is a heterogeneous condition. However, subtypes can be discriminated on the basis of more severe difficulties in fine-motor performance, gross-motor performance, or both. There was evidence for generalized motor impairments in around half of all children. Importantly, at least borderline level reduced balance was evident in each subtype. WHAT THIS PAPER ADDS: Four subtypes were identified in a large clinical group of children with developmental coordination disorder (DCD). Subtypes were based on motor, cognitive, and visual-motor abilities. There was evidence of generalized motor impairments in around 50% of children with DCD. A generalized balance problem is present across all subtypes of DCD.
Asunto(s)
Trastornos de la Destreza Motora , Niño , Femenino , Humanos , Masculino , Destreza Motora , Trastornos de la Destreza Motora/diagnóstico , Desempeño Psicomotor , Visión Ocular , Percepción VisualRESUMEN
AIM: The neurocognitive basis of Developmental Coordination Disorder (DCD; or motor clumsiness) remains an issue of continued debate. This combined systematic review and meta-analysis provides a synthesis of recent experimental studies on the motor control, cognitive, and neural underpinnings of DCD. METHODS: The review included all published work conducted since September 2016 and up to April 2021. One-hundred papers with a DCD-Control comparison were included, with 1,374 effect sizes entered into a multi-level meta-analysis. RESULTS: The most profound deficits were shown in: voluntary gaze control during movement; cognitive-motor integration; practice-/context-dependent motor learning; internal modeling; more variable movement kinematics/kinetics; larger safety margins when locomoting, and atypical neural structure and function across sensori-motor and prefrontal regions. INTERPRETATION: Taken together, these results on DCD suggest fundamental deficits in visual-motor mapping and cognitive-motor integration, and abnormal maturation of motor networks, but also areas of pragmatic compensation for motor control deficits. Implications for current theory, future research, and evidence-based practice are discussed. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier: CRD42020185444.
RESUMEN
BACKGROUND: Receiving a diagnosis can have a major impact on the child and its family. Parental satisfaction concerning the diagnostic trajectory is important with regard to acceptance and coping with their child's problems. Our aim was to describe the diagnostic trajectory of developmental coordination disorder (DCD) in the Netherlands and identify factors that are related to parents' satisfaction. METHOD: Mothers of 60 children with a DCD diagnosis completed an online survey concerning their experiences during and after the diagnostic trajectory of obtaining this diagnosis. RESULTS: Forty percent of the mothers rated the diagnostic trajectory towards a DCD diagnosis as stressful and 47% rated the knowledgeability of the first professional they consulted (mostly a general practitioner, paediatric physical therapist, or youth health care physician) as having no or just superficial knowledge about DCD. Around 60% of the mothers described a lack of knowledge and support at their child's school after receiving the diagnosis. Notwithstanding this, the majority of the participating mothers was (very) satisfied with the diagnostic trajectory. Higher appreciation of both the manner of the diagnosing professional and the post-diagnostic support provided were predictive of higher satisfaction. CONCLUSIONS: Our results underline the importance of improving the knowledgeability in primary schools and primary health care professionals with regard to DCD.
Asunto(s)
Trastornos de la Destreza Motora , Adolescente , Niño , Femenino , Humanos , Madres , Trastornos de la Destreza Motora/diagnóstico , Países Bajos/epidemiología , Relaciones Padres-Hijo , PadresRESUMEN
The second-order motor planning ability of children with developmental coordination disorder (DCD) has often been studied using tasks that require judgements of end-state comfort (ESC). In these studies, children may have chosen to prioritize other aspects of performance (e.g., a comfortable start-posture) over ESC while still being able to complete the goal of the task. This is a limitation that is inherent to previously used ESC paradigms. To avoid this in the present study, 52 children with and without DCD (aged 5-12 years) completed a task that requires second-order motor planning for its successful completion. In the hexagonal knob task, children were instructed to grasp and rotate a hexagonal knob. The rotation angle varied in size: 60°, 120°, 180°, and 240° rotations. Both the 180° and 240° rotation conditions required an uncomfortable starting posture for successful task completion. Results showed that children with DCD were less likely to adjust their initial grip in anticipation of the required rotation angle, resulting in more task failures compared with typically developing (TD) children. Based on this finding we conclude that children with DCD experience genuine second-order motor planning difficulties. Analysis of temporal outcomes, showed that initial reaction time increased with rotation angle, but this was less pronounced for children with DCD than for TD children. There were no between group differences in timing of subsequent events. These results suggest that the difficulties of children with DCD are related to the initial planning process, that is, before the start of the movement.
Asunto(s)
Trastornos de la Destreza Motora , Niño , Fuerza de la Mano , Humanos , Destreza Motora , Movimiento , Tiempo de ReacciónRESUMEN
Children with Developmental Coordination Disorder (DCD) have difficulty performing and learning motor skills. Automatic activation of the mirror neuron system (MNS) during action observation and its coupling to the motor output system are important neurophysiological processes that underpin observational motor learning. In the present study, we tested the hypothesis that MNS function is disrupted in children with DCD by using sensitive electroencephalography (EEG)-based measures of MNS activation during action observation. Specifically, we predicted reduced mu-suppression and coherence in DCD compared with typically developing children. Neural activation of the motor network was measured by EEG, specifically event-related desynchronization (ERD) of mu rhythms and fronto-parietal coherence. Children (15 DCD/15 controls) were tested under two task conditions: observational learning (imitation of an observed action) and detection (report a deviant movement after observation). EEG-metrics were compared between groups using linear mixed-effects models. As predicted, children with DCD showed lower levels of mu suppression and reduced modulation of coherence during the observational learning task compared with their non-DCD peers. Notably, mu suppression was reduced in DCD over the entire imitation task (repetitions, and both observation and pause intervals). Action observation can be used for the acquisition of new motor skills. This form of learning entails the transposition of the observed action to the existing internal representations of the observer's own motor system. The present neurophysiological results suggest that this process of learning is impaired in children with DCD. The results are discussed in relation to current hypotheses on mechanisms of DCD.
RESUMEN
Children with developmental coordination disorder (DCD) have difficulties with the predictive control of movements. This was shown in studies that target motor imagery and motor planning, and appears to become particularly evident with increases in task complexity. In this study, we used a complex mental chronometry paradigm to examine the development of motor imagery ability in children with DCD, using a longitudinal design. Thirty children were included in the DCD group (aged 6-11 years) and age- and gender-matched to 30 controls. The DCD group had a Movement Assessment Battery for Children-2 score ≤16th percentile and the control group ≥25th percentile. Results of this study showed that children with DCD indeed had a significantly lower correlation between executed and imagined movements. Importantly, the increase in the correlation and linear fit during subsequent measurements was comparable for the DCD and control group. Together, these findings suggest a delayed developmental onset of motor imagery ability in DCD, but a similar rate of development over time compared to the control group. Based on these results, it seems likely that explicit motor imagery instructions can be used to improve predictive control in children with DCD.
Asunto(s)
Objetivos , Imaginación , Trastornos de la Destreza Motora/fisiopatología , Destreza Motora , Movimiento , Niño , Femenino , Humanos , MasculinoRESUMEN
Children with impaired motor coordination (or Development Coordination Disorder - DCD) have difficulty with the predictive control of movements, evidenced by cross-sectional studies that show impaired motor imagery and action planning abilities. What remains unclear is whether this deficit in predictive control reflects immaturity of the motor system (a developmental delay) or some deviation from normal development (a disorder). To advance this discussion the present study used a longitudinal design to examine the development of motor imagery and action planning in children with DCD. Thirty children were included in the DCD group (aged 6-11years) and age- and gender-matched to 30 controls. The DCD group had a mABC-2 score≤16th percentile, the control group>20th percentile. Motor imagery was assessed with the hand rotation task, action planning with a test for end-state comfort. Children participated in three measurements, with one year in between measurements. Results showed that children with DCD were slower and less accurate than their typically developing peers in all subsequent years but were able to improve their motor imagery ability over time. Furthermore, children with DCD showed less planning for ESC at the start of the present study, but were able to catch up with their peers during two-year follow up. These results exemplify that improvement of motor imagery and action planning ability is possible in DCD, and they lend theoretical support to the use of new training techniques that focus on training motor imagery to improve motor skills in children with DCD.
Asunto(s)
Anticipación Psicológica/fisiología , Trastornos de la Destreza Motora/psicología , Niño , Estudios Transversales , Femenino , Mano/fisiología , Humanos , Imágenes en Psicoterapia/métodos , Masculino , Destreza Motora/fisiología , Trastornos de la Destreza Motora/fisiopatología , Trastornos de la Destreza Motora/terapia , Movimiento/fisiología , RotaciónRESUMEN
Children with Developmental Coordination Disorder (DCD) experience movement difficulties that may be linked to processes involved in motor imagery (MI). This paper discusses recent advances in theory that underpin the use of MI training for children with DCD. This knowledge is translated in a new MI training protocol which is compared with the cognitive orientation to daily occupational performance (CO-OP). Children meeting DSM-5 criteria for DCD were assigned to MI (n = 4) or CO-OP (n = 4) interventions and completed nine treatment sessions, including homework exercises. Results were positive, with two children in the MI group and three in the CO-OP group improving their m-ABC-2 score by ≥ 2 standard scores, interpreted as a clinically meaningful change. Moreover, all children and parents noticed improvements in motor skills after training. This is the first study to demonstrate the feasibility of a theoretically principled treatment protocol for MI training in children with DCD, and extends earlier work. Trial registration: The complete trial is registered at the Dutch trial register, www.trialregister.nl (NTR5471). http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5471.
RESUMEN
Recent systematic reviews (Wilson et al., 2013, Dev. Med. Child Neurol., 55, 217; Adams et al., 2014, Neurosci. Biobehav. Rev., 47C, 225) suggest that a common underlying problem in developmental coordination disorder (DCD) is the internal modelling deficit. The study presented here is the first to test this hypothesis using a within-subject design, assessing motor imagery, action planning, and rapid online control (ROC) in a sample of children screened rigorously for DCD. Participants were 66 children; 33 children (26 boys and seven girls) aged 6-11 years in the DCD group and 33 controls (gender and age matched). Motor imagery was assessed with the hand rotation task (HRT), action planning with an end-state comfort effect test, and ROC with the double-step pointing task. Results showed that children with DCD were slower and less accurate than controls in the HRT. Reduced forward planning for comfortable end-state was also shown in DCD. Finally, no group differences were found on the ROC task. Collectively, children with DCD manifest deficits in the internal modelling of movements, but this varies under different task constraints, particularly those related to movement complexity.
Asunto(s)
Trastornos de la Destreza Motora/psicología , Destreza Motora , Movimiento , Rotación , Estudios de Casos y Controles , Niño , Femenino , Mano , Humanos , Masculino , Tiempo de ReacciónRESUMEN
AIM: The aim of this study was to examine the specificity of motor imagery (MI) difficulties in children with CP. METHOD: Performance of 22 children with CP was compared to a gender and age matched control group. MI ability was measured with the Hand Laterality Judgment (HLJ) task, examining specifically the direction of rotation (DOR) effect, and the Praxis Imagery Questionnaire (PIQ). RESULTS: In the back view condition of the HLJ task both groups used MI, as evidenced by longer response times for lateral compared with medial rotational angles. In the palm view condition children with CP did not show an effect of DOR, unlike controls. Error scores did not differ between groups. Both groups performed well on the PIQ, with no significant difference between them in response pattern. CONCLUSION AND IMPLICATION: The present study suggests that children with CP show deficits on tasks that trigger implicit use of MI, whereas explicit MI ability was relatively preserved, as assessed using the PIQ. These results suggest that employing more explicit methods of MI training may well be more suitable for children with CP in rehabilitation of motor function.
Asunto(s)
Parálisis Cerebral/psicología , Imaginación , Actividad Motora , Estudios de Casos y Controles , Parálisis Cerebral/fisiopatología , Parálisis Cerebral/rehabilitación , Niño , Preescolar , Femenino , Humanos , Juicio , Masculino , RotaciónRESUMEN
BACKGROUND: Previous studies have shown that the predictive control of movements is impaired in children with Developmental Coordination Disorder (DCD), most likely due to a deficit in the internal modeling of movements. Motor imagery paradigms have been used to test this internal modeling deficit. The aim of the present study is to examine whether a training focused on the mental imagery of motor skills, can help to improve the motor abilities of children with DCD. METHODS/DESIGN: A pre-post design will be used to examine the motor performance, motor imagery and motor planning abilities before and after a training of 9 weeks. Two groups will be included in this study (1) one receiving motor imagery (MI) training focused on the forward modeling of purposive actions, (2) one receiving Cognitive Orientation to daily Occupational Performance (CO-OP) training focused on identifying effective cognitive strategies that will increase motor competence. MI training will be given with the use of instruction videos of the motor skill that will be trained. Both groups will participate in 9 individual sessions of 45 min (once a week) with a paediatric physical or occupational therapist, added with homework sessions. Inclusion criteria are: (1) aged 7-12 years, (2) meeting the DSM-V criteria for DCD (motor performance substantially low (score on the m-ABC ≤ 16th percentile) and motor problems that interfere with daily life (DCDQ, and request for help at a paediatric physical or occupational therapist)). Exclusion criteria are IQ < 70 and other medical conditions causing the motor impairment. DISCUSSION: The results of this study will help to make treatment protocols for children with DCD more evidence-based. This study will increase our knowledge about the efficacy of both the MI training and CO-OP training, and both children with DCD and therapists will benefit from this knowledge. TRIAL REGISTRATION: www.trialregister.nl/NTR5471.
Asunto(s)
Protocolos Clínicos , Imaginación/fisiología , Actividad Motora/fisiología , Trastornos de la Destreza Motora/rehabilitación , Terapia Ocupacional/métodos , Ensayos Clínicos Controlados Aleatorios como Asunto/métodos , Niño , Femenino , Humanos , MasculinoRESUMEN
The present study examined action planning and position sense in children with Developmental Coordination Disorder (DCD). Participants performed two action planning tasks, the sword task and the bar grasping task, and an active elbow matching task to examine position sense. Thirty children were included in the DCD group (aged 6-10years) and age-matched to 90 controls. The DCD group had a MABC-2 total score ⩽5th percentile, the control group a total score ⩾25th percentile. Results from the sword-task showed that children with DCD planned less for end-state comfort. On the bar grasping task no significant differences in planning for end-state comfort between the DCD and control group were found. There was also no significant difference in the position sense error between the groups. The present study shows that children with DCD plan less for end-state comfort, but that this result is task-dependent and becomes apparent when more precision is needed at the end of the task. In that respect, the sword-task appeared to be a more sensitive task to assess action planning abilities, than the bar grasping task. The action planning deficit in children with DCD cannot be explained by an impaired position sense during active movements.
Asunto(s)
Percepción Auditiva , Trastornos de la Destreza Motora/diagnóstico , Trastornos de la Destreza Motora/psicología , Propiocepción , Desempeño Psicomotor , Estimulación Subliminal , Percepción del Tiempo , Adaptación Psicológica , Niño , Femenino , Lateralidad Funcional , Humanos , MasculinoRESUMEN
A viable hypothesis to explain the compromised motor ability of children with Developmental Coordination Disorder (DCD) suggests a fundamental deficit in their ability to utilize internal models for motor control. Dysfunction in this mode of control is thought to compromise their motor learning capabilities. The aim of this systematic review is to examine the available evidence for the internal modeling deficit (IMD) hypothesis. A systematic review using five databases identified 48 relevant articles. These studies were categorized according to the effector system involved in the evaluation of motor control and were evaluated for methodological quality. In most papers, DSM-IV-TR criteria for the classification of DCD were not completely fulfilled and possible attentional problems not accounted for. Results showed compromised control of overt and covert eye movements, dynamic postural control, manual control for tasks that vary in complexity, and for motor imagery of manual and whole-body postures. Importantly, this review shows support for general hypothesis that deficits of predictive control manifest in DCD across effector systems.
Asunto(s)
Trastornos de la Destreza Motora/fisiopatología , Desempeño Psicomotor/fisiología , Atención/fisiología , Niño , Humanos , Modelos NeurológicosRESUMEN
The evolution of handedness in human populations has intrigued scientists for decades. However, whether handedness really affects Darwinian fitness is unclear and not yet studied in a non-industrial society where selection pressures on health and handedness are likely to be similar to the situation in which handedness has evolved. We measured both hand preference and asymmetry of hand skill (speed of fine motor control, measured by a pegboard task, and accuracy of throwing), as they measure different aspects of handedness. We investigated the associations between both the direction (left versus right) and strength (the degree to which a certain preference or asymmetry in skill is manifested, independent of the direction) of handedness. We analyzed to what extent these measures predict the number of offspring and self-reported illness in a non-industrial society in Papua, Indonesia. As it is known that body height and fitness are correlated, data on body height was also collected. Due to low numbers of left-handers we could not investigate the associations between direction of hand preference and measures of Darwinian fitness. We found a positive association between strength of asymmetry of hand skill (pegboard) and the number of children men sired. We also found a positive association for men between strength of hand preference and number of children who died within the first three years of life. For women we found no such effects. Our results may indicate that strength of handedness, independent of direction, has fitness implications and that the persistence of the polymorphism in handedness may be ascribed to either balancing selection on strength of asymmetry of hand skill versus strength of hand preference, or sexual antagonistic selection. No relationships between health and handedness were found, perhaps due to disease related selective disappearance of subjects with a specific handedness.
Asunto(s)
Lateralidad Funcional/fisiología , Industrias , Reproducción/fisiología , Sociedades , Niño , Mortalidad del Niño , Padre , Femenino , Humanos , Masculino , Modelos Estadísticos , Madres , Destreza Motora/fisiología , Análisis de Regresión , Tamaño de la Muestra , Autoinforme , Adulto JovenRESUMEN
Considerable variation in the frequency of left-handedness between cultures has been reported, ranging from 0.5 to 24%. This variation in hand preference may have evolved under natural or cultural selection. It has been suggested that schooling affects handedness but as in most human societies only a selected and minor part of the population does not attend school this is difficult to test. We investigated to what extent schooling affects both hand preference and asymmetry in hand skill in a non-industrial population in the highlands of New Guinea. This provided unique opportunities because of the relatively recent establishment of a primary school in this population, and where people still live a non-industrial traditional life reflecting conditions in which handedness may have evolved. We interviewed 620 inhabitants (aged 5-70 y) to collect demographic data and school history, tested hand preference on 10 ecologically relevant activities, and measured performance of each hand on three tasks (pegboard, grip force, ball throwing). Schooled individuals were overall faster in fine motor performance, had greater grip strength and greater throwing accuracy. This suggests that there is implicit selection on the fitter part of the population to enter school. Schooling is associated with hand preference, as schooled individuals were more likely to be extremely right-handed and less likely to be strongly right-handed, but not with asymmetry of hand skill (controlled for sex and age). Developmental plasticity in hand preference but not skill asymmetry, and the weak correlations between hand preference and hand skill asymmetry indicate that they represent different aspects of brain lateralization. Furthermore, the weak correlations between hand preference and hand skill asymmetry leave room for moderating factors such as schooling, sex and age to have a differential effect on hand preference and hand skill, and each needs to be studied in its own right.
Asunto(s)
Lateralidad Funcional/fisiología , Mano , Desempeño Psicomotor/fisiología , Adolescente , Adulto , Factores de Edad , Anciano , Análisis de Varianza , Niño , Preescolar , Femenino , Fuerza de la Mano/fisiología , Humanos , Masculino , Persona de Mediana Edad , Dinamómetro de Fuerza Muscular , Valor Predictivo de las Pruebas , Tiempo de Reacción/fisiología , Factores Sexuales , Adulto JovenRESUMEN
OBJECTIVE: Handedness is the most noticeable functional expression of cerebral lateralization in humans. However, its developmental process and plasticity remain elusive. It has been postulated that prenatal testosterone (pT) has an effect on human lateralization development. In the present study we examined the relationship between pT and handedness and compared the outcome to previously published data on language lateralization in the same children. METHOD: pT was assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice during performance of age appropriate tasks. Regression procedures and the Olkin & Siotani Z-statistic were used. RESULTS: Results demonstrate that higher pT exposure was related to a decrease in strength of handedness (R² = .11, p = .01). The analysis shows that pT has quite stronger explanatory power than sex by itself, although there may be an additional effect of sex independent from pT. In a subgroup of these children we recently reported that higher levels of pT are related to increased left hemisphere dominance for language. Analyses show that pT is differentially related to handedness and language lateralization in these children (Z > 2.75, p < .003). CONCLUSIONS: Results imply a differential effect of pT on language lateralization and handedness. This may be explained by differential sensitivity of different areas of the corpus callosum or hemispheres for androgens, fuelling the ongoing debate about the relationship between prenatal exposure to testosterone and lateralization of brain and behavior.