RESUMEN
Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide and is endemic in Europe, including Denmark. Several non-liver manifestations have been apparent, the most important of which is neurological, including neuralgic amyotrophy and Guillain-Barré syndrome as summarised in this review. Certain neurological presentations and patients with unexplained mild to moderate increase in liver enzymes, should lead to the consideration of a HEV-related condition. Many research questions regarding HEV-related neurological injury remain unanswered and need further investigation.
Asunto(s)
Neuritis del Plexo Braquial , Síndrome de Guillain-Barré , Virus de la Hepatitis E , Hepatitis E , Enfermedades del Sistema Nervioso , Síndrome de Guillain-Barré/diagnóstico , Síndrome de Guillain-Barré/etiología , Hepatitis E/complicaciones , Hepatitis E/diagnóstico , Hepatitis E/epidemiología , Humanos , Enfermedades del Sistema Nervioso/etiologíaRESUMEN
Ketogenic diet (KD) has for a long time been known as an effective treatment for medically intractable epilepsy. However, the underlying mechanism is still unknown. Recent work indicates, that several mechanisms exist for KD, including neurotransmitter regulation, glucose restriction, effects of fatty acids, altered mitochondrial function and mammalian target of rapamycin pathway. Revealing the mechanisms of KD provides a better insight in the pathophysiology of epilepsy and helps the development of new treatments of epilepsy and other neurological disorders.