1.
Chem Rev
; 111(3): 2177-250, 2011 Mar 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21391570
2.
Chem Rev
; 109(9): 4398-438, 2009 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19537777
Asunto(s)
Antivirales/química , Inhibidores Enzimáticos/química , Gripe Humana/tratamiento farmacológico , Neuraminidasa/antagonistas & inhibidores , Oseltamivir/química , Zanamivir/química , Antivirales/síntesis química , Antivirales/uso terapéutico , Inhibidores Enzimáticos/síntesis química , Inhibidores Enzimáticos/uso terapéutico , Humanos , Neuraminidasa/metabolismo , Oseltamivir/síntesis química , Oseltamivir/uso terapéutico , Zanamivir/síntesis química , Zanamivir/uso terapéutico
3.
J Org Chem
; 71(18): 7103-5, 2006 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16930076
RESUMEN
A new reagent for the deprotection of aromatic methyl ethers, 2-(diethylamino)ethanethiol, is reported. This compound, commercially available as its HCl salt, affords the corresponding phenols in good to excellent yields on a wide variety of substrates. A clear advantage of this method over the use of more common thiols, such as ethanethiol, is the easy extraction of both the deprotecting reagent and the byproduct 2-(diethylamino)ethyl methyl sulfide into the aqueous phase by quenching with dilute acid, which allows an essentially odorless workup.