Age-related differences in the impact of mind-wandering and visual distraction on performance in a go/no-go task.

Optimal performance in many tasks requires minimizing the impact of both visual distraction and mind-wandering. Yet, so far, these two types of distraction have been studied in isolation and it remains unclear whether they act in similar or dissociable ways across age groups. Here, we studied the impact of visual distraction and mind-wandering on performance in a go/no-go task in young and older adults. Older adults reported higher task focus than young, which was associated with a specific age-related reduction in mind-wandering, rather than to thoughts triggered by the task. Older adults exhibited fewer no-go errors, higher mean reaction time (RT) and reduced RT variability compared to young adults. In contrast, visual distraction was associated with a disproportionate effect in older versus young adults on go accuracy, mean RT, and RT variability. Decreasing task focus was similarly associated with reduced go- and no-go accuracy and increased RT variability across age groups. In summary, our results suggest that whereas older adults are disproportionately affected by visual distraction compared to young, they exhibit a reduction in mind-wandering frequency. Moreover, the impact of decreasing task focus on task performance is similar across age groups. Our results suggest a dissociation of the impact of visual distraction and mind-wandering as a function of age. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Differential effects of mind-wandering and visual distraction on age-related changes in neuro-electric brain activity and variability.

Optimal performance in many tasks requires minimizing the impact of both visual distractors in the environment and distracting internal thoughts (i.e., mind-wandering). Prior research has indicated that older adults are disproportionately affected by the presence of visual distractors compared to young adults, but are not excessively affected by distracting thoughts. Yet an explanation for these dissociable effects remains elusive. In the current study, we assessed age-related differences in event-related potentials and neural variability associated with internal distraction and visual distractors in a go/no-go task. Compared to young adults, older adults showed an increased visual distraction cost in mean reaction time (RT) and RT variability but a reduction in internal distraction frequency and a reduced internal distraction cost on go accuracy and RT variability. Visual distraction and internal distraction were associated with opposite patterns of behavioral and neural effects. Behaviorally, across age groups, internal distraction was associated with more no-go errors whereas visual distraction was associated with reduced no-go errors. Across groups, internal distraction was associated with decreased P3 amplitude, whereas visual distraction was associated with increased P3 amplitude. In addition, internal distraction was associated with an increase in neural variability (more so in young versus older adults), while visual distraction was associated with a reduction in variability in young adults only. We suggest that the opposing effects of the two distractor types on behavioral and neural measures occur because visual distraction is associated with increased attentional resources devoted to the task to overcome visual interference whereas internal distraction is associated with decreased attentional resources devoted to the task. Moreover, older adults exhibited reduced flexibility of neural variability as a function of both distractor types, which may correspond to a diminished ability to up-regulate attention in the face of visual distraction and a diminished shift in attention away from the task during internal distraction.

Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts.

In recent years, several studies have indicated that healthy older adults exhibit a reduction in task-unrelated thoughts compared to young adults. However, much less is known regarding age-related differences in time spent engaging in stimulus-independent thoughts or in their neural correlates in the absence of an ongoing task. In the current study, we collected functional magnetic resonance imaging (fMRI) data while 29 young (mean age = 22y) and 22 older (mean age = 70y) adults underwent experience sampling in the absence of an ongoing task (i.e., at "rest"). Although both age groups reported spending a similar amount of time engaged in stimulus-independent thoughts, older adults rated their thoughts as more present-oriented (rather than atemporal) and more novel. Moreover, controlling for these age-related differences in content, we found that experiencing stimulus-independent thoughts was associated with increased posterior cingulate and left angular gyrus activation across age groups compared to exhibiting an external focus of attention. When experiencing stimulus-independent thoughts, younger adults engaged medial and left lateral prefrontal cortex as well as left superior temporal gyrus to a greater degree than older adults. Taken together, our results suggest that, in the absence of an ongoing task, although young and older adults spend a similar amount of time engaging in stimulus-independent thoughts, the content and neural correlates of these thoughts differ with age.

Large-scale network interactions involved in dividing attention between the external environment and internal thoughts to pursue two distinct goals.

Previous research suggests that default-mode network (DMN) and dorsal attention network (DAN) are involved in internally- and externally-directed attention, respectively, through interactions with salience network (SN) and frontoparietal network (FPCN). Performing a task requiring external attention is often accompanied by a down-regulation of attention to internal thoughts, and vice-versa. In contrast, we often divide our attention between the external environment and internal thoughts to pursue distinct goals, yet virtually no prior research has examined how brain networks support this functionally critical neurocognitive process. In the current study, participants planned their responses for an upcoming alternate uses divergent thinking task (AUT-Condition), indicated whether arrows were pointing left or right (Arrows-Condition) or performed both tasks simultaneously (Dual-Task condition). Behaviorally, the Dual-Task condition was associated with equivalent generation of alternate uses but increased RT variability compared to the single-task conditions. Static connectivity analyses indicated that FPCN and SN increased their connectivity to DMN and reduced their connectivity to DAN during the Dual-Task condition and the AUT-Condition compared to the Arrows-Condition. Furthermore, DAN-SN connectivity was highest during the Arrows-Condition, intermediate during the Dual-Task condition and lowest during the AUT-Condition. Finally, time-varying connectivity analyses indicated that individuals who reported spending less time thinking of alternate uses during the Dual-Task condition spent more time in a state associated with performing the Arrows-Condition. Overall, our results suggest that interactions between DMN, FPCN, SN and DAN allow internal-external dual-tasking, and that time-varying functional connectivity between these networks is sensitive to attentional fluctuations between tasks during dual-tasking.

Age-related differences in mind-wandering in daily life.

In recent years, several laboratory studies have indicated that healthy older adults exhibit a reduction in mind-wandering frequency compared with young adults. However, it is unclear if these findings extend to daily life settings. In the current study, using experience sampling over the course of a week in the daily life of 31 young and 20 older adults, we assessed age-related differences in: (a) mind-wandering frequency, (b) the relationship between affect and mind-wandering frequency, and (c) content of mind wandering. Older adults mind wandered less than young adults in daily life. Across age groups, negative affect was positively associated with mind-wandering occurrence. Finally, older adults reported that their thoughts were more pleasant, interesting, and clear compared with young adults, who had thoughts that were more dreamlike, novel, strange, and racing. Our results provide the first demonstration using thought sampling that older adults exhibit a reduction in mind-wandering frequency in daily life. Implications for current theories of age-related reductions in mind-wandering frequency are discussed. (PsycINFO Database Record

Mind-Wandering as a Natural Kind: A Family-Resemblances View.

As empirical research on mind-wandering accelerates, we draw attention to an emerging trend in how mind-wandering is conceptualized. Previously articulated definitions of mind-wandering differ from each other in important ways, yet they also maintain overlapping characteristics. This conceptual structure suggests that mind-wandering is best considered from a family-resemblances perspective, which entails treating it as a graded, heterogeneous construct and clearly measuring and describing the specific aspect(s) of mind-wandering that researchers are investigating. We believe that adopting this family-resemblances approach will increase conceptual and methodological connections among related phenomena in the mind-wandering family and encourage a more nuanced and precise understanding of the many varieties of mind-wandering.

Mind-wandering and task stimuli: Stimulus-dependent thoughts influence performance on memory tasks and are more often past- versus future-oriented.

Although many studies have indicated that participants frequently mind-wander during experimental tasks, relatively little research has examined the extent to which such thoughts are triggered by task stimuli (stimulus-dependent thoughts; SDTs) versus internally triggered (stimulus-independent thoughts; SITs). In the current experiment, we assessed differences in the frequency and characteristics of SDTs and SITs, as well as their associations with subsequent memory in young adults. Whereas frequency of SDTs (but not SITs) increased in a task with more meaningful stimuli, frequency of SITs (but not SDTs) increased in an easier task. Furthermore, only SDTs were more likely to be past- versus future-oriented. Finally, frequency and vividness of SDTs during a shallow, but not a deep, incidental encoding task both correlated with later memory performance for word stimuli. These results suggest that SDTs differ from SITs in several important ways.

Cognitive aging and the distinction between intentional and unintentional mind wandering.

A growing number of studies have reported age-related reductions in the frequency of mind wandering. Here, at both the trait (Study 1) and state (Study 2) levels, we reexamined this association while distinguishing between intentional (deliberate) and unintentional (spontaneous) mind wandering. Based on research demonstrating age-accompanied deficits in executive functioning, we expected to observe increases in unintentional mind wandering with increasing age. Moreover, because aging is associated with increased task motivation, we reasoned that older adults might be more engaged in their tasks, and hence, show a more pronounced decline in intentional mind wandering relative to young adults. In both studies, we found that older adults did indeed report lower rates of intentional mind wandering compared with young adults. However, contrary to our expectations, we also found that older adults reported lower rates of unintentional mind wandering (Studies 1 and 2). We discuss the implications of these findings for theories of age-related declines in mind wandering. (PsycINFO Database Record

Exploring the influence of encoding format on subsequent memory.

Distinctive encoding is greatly influenced by gist-based processes and has been shown to suffer when highly similar items are presented in close succession. Thus, elucidating the mechanisms underlying how presentation format affects gist processing is essential in determining the factors that influence these encoding processes. The current study utilised multivariate partial least squares (PLS) analysis to identify encoding networks directly associated with retrieval performance in a blocked and intermixed presentation condition. Subsequent memory analysis for successfully encoded items indicated no significant differences between reaction time and retrieval performance and presentation format. Despite no significant behavioural differences, behaviour PLS revealed differences in brain-behaviour correlations and mean condition activity in brain regions associated with gist-based vs. distinctive encoding. Specifically, the intermixed format encouraged more distinctive encoding, showing increased activation of regions associated with strategy use and visual processing (e.g., frontal and visual cortices, respectively). Alternatively, the blocked format exhibited increased gist-based processes, accompanied by increased activity in the right inferior frontal gyrus. Together, results suggest that the sequence that information is presented during encoding affects the degree to which distinctive encoding is engaged. These findings extend our understanding of the Fuzzy Trace Theory and the role of presentation format on encoding processes.

When the mind wanders: Distinguishing stimulus-dependent from stimulus-independent thoughts during incidental encoding in young and older adults.

In recent years, several studies have indicated that healthy older adults exhibit a reduction in mind-wandering compared with young adults. However, relatively little research has examined the extent to which ongoing thoughts in young and older adults are dependent on environmental stimuli. In the current study, we assessed age-related differences in frequency of stimulus-dependent thoughts (SDTs) and stimulus-independent thoughts (SITs) during a slow-paced incidental encoding task. Based on previous research suggesting that older adults rely on external information to a greater extent than young adults, we hypothesized that ongoing thoughts in older adults may be more stimulus-dependent than in young adults. We found that although older adults reported overall fewer thoughts compared to young adults, they exhibited a reduction in proportion of SITs and an increase in proportion of SDTs. In both age groups, SDTs were more frequently about the past compared with SITs, while SITs were more frequently about the future. Finally, the extent to which both young and older adults reported SDTs, but not SITs, at encoding was positively correlated with how often they reported remembering thoughts at retrieval, and SDT frequency was positively correlated with overall performance on the memory task in older adults. Our results provide evidence that ongoing thoughts in older adults may be more dependent on environmental stimuli than young adults, and that these thoughts may impact performance in recognition tasks. (PsycINFO Database Record

Default Network and Aging: Beyond the Task-Negative Perspective.

During cognitive tasks requiring externally directed attention, activation in the default-network (DN) typically decreases below baseline levels ('deactivation'). Healthy aging is associated with reduced deactivation, which is usually attributed to a failure to suppress DN processes. Recent evidence instead suggests that older adults may be more reliant on DN than young adults when performing these tasks.

Assessing the Neural Correlates of Task-unrelated Thoughts during Episodic Encoding and Their Association with Subsequent Memory in Young and Older Adults.

Recent evidence indicates that young adults frequently exhibit task-unrelated thoughts (TUTs) such as mind-wandering during episodic encoding tasks and that TUTs negatively impact subsequent memory. In the current study, we assessed age-related differences in the frequency and neural correlates of TUTs during a source memory encoding task, as well as age-related differences in the relationship between the neural correlates of TUTs and subsequent source forgetting effects (i.e., source misses). We found no age-related differences in frequency of TUTs during fMRI scanning. Moreover, TUT frequency at encoding was positively correlated with source misses at retrieval across age groups. In both age groups, brain regions including bilateral middle/superior frontal gyri and precuneus were activated to a greater extent during encoding for subsequent source misses versus source hits and during TUTs versus on-task episodes. Overall, our results reveal that, during a source memory encoding task in an fMRI environment, young and older adults exhibit a similar frequency of TUTs and that experiencing TUTs at encoding is associated with decreased retrieval performance. In addition, in both age groups, experiencing TUTs at encoding is associated with increased activation in some of the same regions that exhibit subsequent source forgetting effects.

From mind wandering to involuntary retrieval: Age-related differences in spontaneous cognitive processes.

The majority of studies that have investigated the effects of healthy aging on cognition have focused on age-related differences in voluntary and deliberately engaged cognitive processes. Yet many forms of cognition occur spontaneously, without any deliberate attempt at engaging them. In this article we review studies that have assessed age-related differences in four such types of spontaneous thought processes: mind-wandering, involuntary autobiographical memory, intrusive thoughts, and spontaneous prospective memory retrieval. These studies suggest that older adults exhibit a reduction in frequency of both mind-wandering and involuntary autobiographical memory, whereas findings regarding intrusive thoughts have been more mixed. Additionally, there is some preliminary evidence that spontaneous prospective memory retrieval may be relatively preserved in aging. We consider the roles of age-related differences in cognitive resources, motivation, current concerns and emotional regulation in accounting for these findings. We also consider age-related differences in the neural correlates of spontaneous cognitive processes.

Context Memory Decline in Middle Aged Adults is Related to Changes in Prefrontal Cortex Function.

The ability to encode and retrieve spatial and temporal contextual details of episodic memories (context memory) begins to decline at midlife. In the current study, event-related fMRI was used to investigate the neural correlates of context memory decline in healthy middle aged adults (MA) compared with young adults (YA). Participants were scanned while performing easy and hard versions of spatial and temporal context memory tasks. Scans were obtained at encoding and retrieval. Significant reductions in context memory retrieval accuracy were observed in MA, compared with YA. The fMRI results revealed that overall, both groups exhibited similar patterns of brain activity in parahippocampal cortex, ventral occipito-temporal regions and prefrontal cortex (PFC) during encoding. In contrast, at retrieval, there were group differences in ventral occipito-temporal and PFC activity, due to these regions being more activated in MA, compared with YA. Furthermore, only in YA, increased encoding activity in ventrolateral PFC, and increased retrieval activity in occipital cortex, predicted increased retrieval accuracy. In MA, increased retrieval activity in anterior PFC predicted increased retrieval accuracy. These results suggest that there are changes in PFC contributions to context memory at midlife.

Age-related differences in brain activity in the subsequent memory paradigm: a meta-analysis.

Healthy aging is associated with declines in episodic memory. This reduction is thought to be due in part to age-related differences in encoding-related processes. In the current study, we performed an activation likelihood estimation meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing age-related differences in the neural correlates of episodic encoding. Only studies using the subsequent memory paradigm were included. We found age-related under-recruitment of occipital and fusiform cortex, but over-recruitment in a set of regions including bilateral middle/superior frontal gyri, anterior medial frontal gyrus, precuneus and left inferior parietal lobe. We demonstrate that all of the regions consistently over-recruited by older adults during successful encoding exhibit either direct overlap, or occur in close vicinity to regions consistently involved in unsuccessful encoding in young adults. We discuss the possibility that this overall pattern of age-related differences represents an age-related shift in focus: away from perceptual details, and toward evaluative and personal thoughts and feelings during memory tasks. We discuss whether these age-related differences in brain activation benefit performance in older adults, and additional considerations.

Dissociable roles of default-mode regions during episodic encoding.

We investigated the role of distinct regions of the default-mode network (DMN) during memory encoding with fMRI. Subjects encoded words using either a strategy that emphasized self-referential (pleasantness) processing, or one that emphasized semantic (man-made/natural) processing. During encoding subjects were intermittently presented with thought probes to evaluate if they were concentrated and on-task or exhibiting task-unrelated thoughts (TUT). After the scanning session subjects performed a source retrieval task to determine which of two judgments they performed for each word at encoding. Source retrieval accuracy was higher for words encoded with the pleasantness vs. the man-made/natural task and there was a trend for higher performance for words preceding on-task vs. TUT reports. fMRI results show that left anterior medial PFC and left angular gyrus activity was greater during successful vs. unsuccessful encoding during both encoding tasks. Greater activity in left anterior cingulate and bilateral lateral temporal cortex was related successful vs. unsuccessful encoding only in the pleasantness task. In contrast, posterior cingulate, right anterior cingulate and right temporoparietal junction were activated to a greater extent in unsuccessful vs. successful encoding across tasks. Finally, activation in posterior cingulate and bilateral dorsolateral prefrontal cortex was related to TUT across tasks; moreover, we observed a conjunction in posterior cingulate between encoding failure and TUT. We conclude that DMN regions play dissociable roles during memory formation, and that their association with subsequent memory may depend on the manner in which information is encoded and retrieved.

Age-related changes in frequency of mind-wandering and task-related interferences during memory encoding and their impact on retrieval.

During the performance of cognitive tasks such as memory encoding, attention can become decoupled from the external environment and instead focused on internal thoughts related to the appraisal of the current task (task-related interferences; TRI), or personal thoughts unrelated to the task at hand (mind-wandering; MW). However, the association between the frequency of these thoughts experienced at encoding and retrieval accuracy in young and older adults remains poorly understood. In this study young and older adults encoded lists of words using one of two encoding tasks: judging whether words are man-made/natural (objective task), or whether they are pleasant/neutral (subjective task). We measured the frequency of TRI and MW at encoding, and related them to retrieval accuracy in both age groups. We found that encoding task influenced the type of internal thoughts experienced by young, but not older, adults: young exhibited greater MW in the subjective vs the objective task, and greater TRI in the objective vs subjective encoding task. Second, across both tasks we found marked age-related decreases in both MW and TRI at encoding, and frequency of these thoughts negatively impacted memory retrieval in young adults only. We discuss these findings in relation to current theories of ageing, attention and memory.

Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: a review.

Functional neuroimaging studies have consistently reported age-related changes in prefrontal cortex (PFC) activity during a variety of cognitive tasks, including episodic memory. These changes are often interpreted within the context of one of the following three neural models of age-related changes in brain function: dedifferentiation, neural inefficiency, and neural plasticity and compensation models. Distinguishing between these competing models has proven difficult when interpreting results using functional imaging data alone. In this paper we suggest that a more accurate interpretation of age-related changes in PFC activity requires consideration of age-related differences in gray matter volume (GMv) in PFC and the medial temporal lobes (MTL). We review fMRI studies of cognitive aging that have directly examined the relationship between PFC activity and both local (PFC) and distal (MTL) GMv in older versus younger adults. We also considered how structure-function relationships may be further modified in pathological aging (i.e. mild cognitive impairment (MCI) and Alzheimer's disease (AD)). We found that when task performance was matched between age-groups there was a negative association between regional PFC volume and activity in older adults. However, when older adults performed worse than young adults we observed a positive association between volume and activity in right lateral PFC. Additionally during memory tasks, several studies revealed that PFC activity is positively related to GM volume in MTL in healthy older adults, but negatively related in MCI and AD patients. We conclude that PFC activity is related to age-related changes in local and distal GM volume reductions and that consideration of these structural measures aids the interpretation of fMRI results. Furthermore, the study of structure-function relationships may provide important insights into the biological mechanisms underlying healthy versus pathological aging.

Age-related changes in the three-way correlation between anterior hippocampus volume, whole-brain patterns of encoding activity and subsequent context retrieval.

Age-related declines in memory for context have been linked to volume loss in the hippocampal head (HH) with age. However, it remains unclear how this volumetric decline correlates with age-related changes in whole-brain activity during context encoding, and subsequent context retrieval. In the current study we examine this. We collected functional magnetic resonance imaging data in young and older adults during the encoding of item, spatial context and temporal context. HH volume and subsequent retrieval performance was measured in all participants. In young adults only there was a positive three-way correlation between larger HH volumes, better memory retrieval, and increased activity in right hippocampus, right ventrolateral prefrontal cortex (VLPFC) and midline brain regions during episodic encoding. In contrast, older adults exhibited a positive three-way association between HH volume, generalized activity in bilateral hippocampus and dorsolateral PFC across all encoding tasks, and subsequent spatial context retrieval. Young adults also engaged this network, but only during the most difficult temporal context encoding task and activity in this network correlated with subsequent temporal context retrieval. We conclude that age-related volumetric reductions in HH disrupted the structure-function association between the hippocampus and activity in the first general encoding network recruited by young adults. Instead, older adults recruited those brain regions young adults only engaged for the most difficult temporal task, at lower difficulty levels. This altered pattern of association correlated with spatial context retrieval in older adults, but was not sufficient to maintain context memory abilities overall.