[Use of the expired air condensate in the study of biochemistry of bronchial contents in patients with bronchial asthma]. / Ispol'zovanie kondensata vydykhaemogo vozdukha dlia issledovaniia biokhimicheskogo sostava soderzhimogo bronkhov u bol'nykh bronkhial'noi astmoi.

A total of 7 patients with premorbid adjustment (PA) and 13 patients with bronchial asthma (BA) were comparatively studied for the content of calcium, magnesium and biogenic amines (histamine, serotonin) which were assessed with atom absorption spectrophotometry and fluorimetry in the condensate of expired air (CEA), fluid of the bronchial wash-off (FBW) and bronchoalveolar lavage (BAL). It was revealed that the studied values in CEA were similar to those in FBW and BAL. The results obtained indicated that CEA adequately demonstrated the biochemical composition of bronchial contents in various generations and alveoli. CEA availability and high informative value permitted it to be employed in the research into the mechanisms of bronchial obstruction as well as in the control for the efficacy of BA and PA treatment.

[The level of biogenic amines in bronchi of patients with chronic obstructive bronchitis]. / Soderzhanie biogennykh aminov v bronkhakh bol'nykh khronicheskim obstructivnym bronkhitom.

Histamine and serotonin levels were measured in expired air humidity condensate (EAHC), bronchoalveolar lavage fluid and sputum of 9 patients with chronic nonobstructive bronchitis and 25 healthy controls. It was found that concentration of biogenic amines depended on the form of chronic bronchitis, activity of bronchial inflammation, characteristics of bronchial obstruction, degree of respiratory insufficiency. EAHC furnished most complete information.

[The therapeutic potentials of magnesium sulfate in bronchial asthma]. / Terapevticheskie vozmozhnosti sul'fata magniia pri bronkhial'noi astme.

Twelve patients with preasthma (PA) and 27 bronchial asthma (BA) patients were examined for the effect of magnesium sulphate aerosol on bronchial sensitivity and reactivity to acetylcholine (ACC) and graded physical exercise (GPE) as well as on bronchial patency recorded by general plethysmography and pneumotachography. Inhalation of the drug was established to exert no bronchodilatory action but reduced, as compared with placebo, nonspecific hyperreactivity of the bronchial tree and blocked the ACC induced increment of histamine in the exhaled air condensate. The data obtained allow bronchial smooth muscles and mast cells to be regarded as targets for magnesium sulphate. The drug properties discovered may serve a prerequisite for its use in the combined treatment of BA patients and those with PA.