Mandibular Aneurysmal Bone Cyst: About One Case

ABSTRACT: Aneurysmal bone cyst (ABC) is a benign multilocular expansive osteolytic pseudotumor with hematic content whose etiopathogeny is very controversial and whose histopathological diagnosis is sometimes difficult. The case of a 34 year old patient is reported, with no previous history, consulted for a right the mandibular angle and ramus swelling increasing in size, progressively hard, painless, cold, an orthopantomogram was performed in our patient completed by a facial CT scan in coronal and 3D axial sections. In view of our strong suspicion of aneurysmal cyst, we performed a fine needle puncture under general anesthesia before any operative gesture, which brought back a pure hematic liquid. We scheduled our patient for radical surgery: interrupting hemimandibulectomy of the horizontal branch at the right mandibular angle, with immediate reconstruction by maxipl ate given the extent of the tumor. Aneurysmal bone cyst was described in 1940 by Ewing and individualized by Jaffe and Lichtenstein (1942) who gave it their names. Clinically, the painless facial swelling, predominantly mandibular, is the main symptom and responsible for facial asymmetry. The paraclinical examinations requested are mainly orthopantomogram and facial CT scan. The treatment of ABC is exclusively surgical, either conservative or radical. The positive diagnosis of aneurysmal cyst is brou ght by imaging and the confirmation is anatomopathological. Regular clinical and laboratory follow-up is required to detect any recurrence. Many minimally invasive treatments are currently available.

RESUMEN: El quiste óseo aneurismático (QA) es un pseudotumor osteolítico expansivo multilocular benigno con contenido hemático cuya etiopatogenia es controvertida de difícil diagnóstico histopatológico Se reporta el caso de un paciente de 34 años, sin antecedentes previos, que consultó por aumento de tamaño del ángulo y rama mandibular derecha, progresivamente duro, indoloro, frío. Al paciente se le realizó ortopantomografía completada con tomografía computarizada facial en secciones coronal y axial 3D. Ante nuestra sospecha de quiste aneurismático, realizamos una punción con aguja fina bajo anestesia general antes de cualquier gesto operatorio, que devolvió un líquido hemático puro. Programamos al paciente para cirugía radical: hemimandibulectomía interrumpida de la rama horizontal en el ángulo mandibular derecho, con reconstrucción inmediata mediante maxiplaca dada la extensión del tumor. El quiste óseo aneurismático fue descrito en 1940 por Ewing e individualizado por Jaffe y Lichtenstein (1942) quienes le dieron sus nombres. Clínicamente, la tumefacción facial indolora, de predominio mandibular, es el síntoma principal y responsable de la asimetría facial. Los exámenes clínicos solicitados son principalmente la ortopantomografía y tomografía computarizada facial. El tratamiento del ABC es exclusivamente quirúrgico, ya sea conservador o radical. El diagnóstico positivo de quiste aneurismático se da por imagen y la confirmación es anatomopatológica. Se requiere un seguimiento clínico y de laboratorio regular para detectar cualquier recurrencia. Muchos tratamientos mínimamente invasivos están disponibles actualmente.

Out-of-hospital cardiac arrest in pregnant women: A 55-patient French cohort study.

AIM: To describe a cohort of pregnant women having suffered an out-of-hospital cardiac arrest (OHCA) and to compare them with nonpregnant women of childbearing age having suffered OHCA. METHODS: Study data were extracted from the French National OHCA Registry between 2011 and 2021. We compared patients in terms of characteristics, care and survival. RESULTS: We included 3,645 women of childbearing age (15-44) who had suffered an OHCA; 55 of the women were pregnant. Pregnant women were younger than nonpregnant victims (30 vs. 35 years, p = 0.006) and were more likely to have a medical history (76.4% vs. 50.5%, p < 0.001) and a medical cause of the OHCA (85.5% vs. 57.2%, p < 0.001). Advanced Life Support was more frequently administered to pregnant women (98.2%, vs. 72.0%; p < 0.001). In pregnant women, the median time of MICU arrival was 20 minutes for the Medical Intensive Care Unit with no difference with nonpregnant women. Survival rate on admission to hospital was higher among pregnant women (43.6% vs. 27.3%; p = 0.009). There was no difference in 30-day survival between pregnant and nonpregnant groups (14.5% vs. 7.3%; p = 0.061). Fetal survival was only observed for OHCAs that occurred during the pregnancy second or third trimester (survival rates: 10.0% and 23.5%, respectively). CONCLUSIONS: Our results show that resuscitation performance does not meet European Resuscitation Council's specific guidelines on OHCA in pregnant women. Although OHCA in pregnancy is rare, the associated prognosis is poor for both woman and fetus. Preventive measures should be reinforced, especially when pregnant women have medical history.

A cartilage-forming tumor of the mandibular angle: a case report.

BACKGROUND: Mandible can be the site of benign or malignant lesions of different origins, including odontogenic and non-odontogenic lesions. Cartilage-forming tumors have been rarely reported at this site. Chondrosarcoma is a rare malignant cartilage-producing neoplasm that is extremely rare in the mandible. The rarity of cartilage-forming tumor occurrence in the mandible can make diagnosis difficult for pathologists, as they do not expect this type of tumor at this anatomical site. Here we report a case of chondrosarcoma of mandibular angle. CASE PRESENTATION: A 70-year-old Moroccan male patient consulted a dentist for wisdom tooth pain. Wisdom tooth extraction was conducted. After 6 months, the patient reported the recurrence of pain associated with swelling in the mandibular area and paresthesia along the path of the mandibular nerve. A panoramic radiograph demonstrated a mixed radiolucent-opaque lesion involving the mandibular angle. Computed tomography showed a large osteolytic spontaneously hypointense and multilobulated lesion. A biopsy was done. Histopathological examination revealed sheets and irregular lobules of atypical cells presenting cartilaginous differentiation. Tumor cells showed severe nuclear atypia and were located within a hyaline cartilage matrix. Some foci of necrosis were noted. Osteoid deposits were not found. The patient was diagnosed with grade III chondrosarcoma and underwent a right segmental mandibulectomy with submandibular lymph node dissection. Macroscopically, the tumor was localized in the mandibular angle with extension in the mandibular body. Histopathology confirmed the previous diagnosis of grade III chondrosarcoma and did not show any lymph node metastasis. CONCLUSIONS: Owing to many histological similarities, grade III chondrosarcoma must be distinguished from chondroblastic osteosarcoma and metastatic lesions. In addition, chondroblastic osteosarcoma of the jawbones has a worse prognosis than chondrosarcoma, making the distinction between these two malignant tumors the most important concern of the pathologist when dealing with a cartilage-forming tumor at this site. Surgery with wide excision margins remains the best therapeutic approach, while the role of radiotherapy is controversial. The management of mandibular chondrosarcoma requires a multidisciplinary approach involving maxillofacial surgeons, radiologists, pathologists, and oncologists.

Coronavirus Disease 2019 and Out-of-Hospital Cardiac Arrest: No Survivors.

OBJECTIVES: To describe and compare survival among patients with out-of-hospital cardiac arrest as a function of their status for coronavirus disease 2019. DESIGN: We performed an observational study of out-of-hospital cardiac arrest patients between March 2020 and December 2020. Coronavirus disease 2019 status (confirmed, suspected, or negative) was defined according to the World Health Organization's criteria. SETTING: Information on the patients and their care was extracted from the French national out-of-hospital cardiac arrest registry. The French prehospital emergency medical system has two tiers: the fire department intervenes rapidly to provide basic life support, and mobile ICUs provide advanced life support. The study data (including each patient's coronavirus disease 2019 status) were collected by 95 mobile ICUs throughout France. PATIENTS: We included 6,624 out-of-hospital cardiac arrest patients: 127 cases with confirmed coronavirus disease 2019, 473 with suspected coronavirus disease 2019, and 6,024 negative for coronavirus disease 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The "confirmed" and "suspected" groups of coronavirus disease 2019 patients had similar characteristics and were more likely to have suffered an out-of-hospital cardiac arrest with a respiratory cause (confirmed: 53.7%, suspected coronavirus disease 2019: 56.5%; p = 0.472) than noncoronavirus disease 2019 patients (14.0%; p < 0.001 vs confirmed coronavirus disease 2019 patients). Advanced life support was initiated for 57.5% of the confirmed coronavirus disease 2019 patients, compared with 64.5% of the suspected coronavirus disease 2019 patients (p = 0.149) and 70.6% of the noncoronavirus disease 2019 ones (p = 0.002). The survival rate at 30-day postout-of-hospital cardiac arrest was 0% in the confirmed coronavirus disease 2019 group, 0.9% in the suspected coronavirus disease 2019 group (p = 0.583 vs confirmed), and 3.5% (p = 0.023) in the noncoronavirus disease 2019 group. CONCLUSIONS: Our results highlighted a zero survival rate in out-of-hospital cardiac arrest patients with confirmed coronavirus disease 2019. This finding raises important questions with regard to the futility of resuscitation for coronavirus disease 2019 patients and the management of the associated risks.

Management and outcomes of cardiac arrests at nursing homes: A French nationwide cohort study.

BACKGROUND: The incidence of cardiac arrest (CA) in nursing homes is rising. Our objective was to compare nursing home CAs with at-home CAs in patients aged 65 and over with regard to the CAs' characteristics, the use and characteristics of cardiopulmonary resuscitation (CPR), and the outcome. METHODS: We performed an ancillary analysis of a French nationwide cohort of over-65 patients having experienced an out-of-hospital CA (at home or in a nursing home) treated by a physician-manned mobile intensive care unit (MICU) between July 2011 and September 2015. RESULTS: Out of 21,720 CAs, 1907 (9%) occurred in a nursing home. The presence of a witness was more frequent in the nursing home than at home (77% vs. 62%, respectively; p < 0.001) and bystander-initiated CPR was more frequent (62% vs. 34%, respectively; p < 0.001). CPR by a MICU was less likely in the nursing home than at home - even after adjustment for the patients' and CAs' characteristics (adjusted odds ratio (aOR) [95% confidence interval] = 0.49 [0.42-0.57]). A return of spontaneous circulation was less frequent in the nursing home than at home (14% vs. 16%, respectively; OR = 0.86 [0.75-0.99]; p = 0.03) except when CPR was performed by the MICU (31% vs. 26%, respectively; OR = 1.25 [1.07-1.47]; p = 0.005). There was no intergroup difference in the CA outcome at day 30. CONCLUSIONS: Nursing home residents who experience a CA are less likely to receive CPR from a MICU. If CPR is performed, however, the residents' prognosis is no worse than that of patients treated at home.