Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches.

Despite significant advancements in oncology, conventional chemotherapy remains the primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of the most prevalent and severe adverse effects associated with these cytotoxic agents. While platinum compounds are well-known for their nephrotoxic potential, other drugs including antimetabolites, alkylating agents, and antitumor antibiotics are also associated. The onset of AKI poses substantial risks, including heightened morbidity and mortality rates, prolonged hospital stays, treatment interruptions, and the need for renal replacement therapy, all of which impede optimal patient care. Various proactive measures, such as aggressive hydration and diuresis, have been identified as potential strategies to mitigate AKI; however, preventing its occurrence during chemotherapy remains challenging. Additionally, several factors, including intravascular volume depletion, sepsis, exposure to other nephrotoxic agents, tumor lysis syndrome, and direct damage from cancer's pathophysiology, frequently contribute to or exacerbate kidney injury. This article aims to comprehensively review the epidemiology, mechanisms of injury, diagnosis, treatment options, and prevention strategies for AKI induced by conventional chemotherapy.

Gastrointestinal Features of 22q11.2 Deletion Syndrome Include Chronic Motility Problems From Childhood to Adulthood.

OBJECTIVES: 22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion syndrome and has a multisystemic presentation including gastrointestinal features that have not yet been fully described. Our aim was to examine lifetime gastrointestinal problems in a large cohort of patients with 22q11.2DS. METHODS: All patients followed in the 22q and You Center at the Children's Hospital of Philadelphia (n = 1421) were retrospectively screened for: 1) age ≥ 17 years, 2) documented chromosomal microdeletion within the 22q11.2 LCR22A-LCR22D region, and 3) sufficient clinical data to characterize the adult gastrointestinal phenotype. Gastrointestinal problems in childhood, adolescence, and adulthood were summarized. Statistical association testing of symptoms against other patient characteristics was performed. RESULTS: Included patients (n = 206; 46% female; mean age, 27 years; median follow-up, 21 years) had similar clinical characteristics to the overall cohort. Genetic distribution was also similar, with 96% having deletions including the critical LCR22A-LCR22B segment (95% in the overall cohort). Most patients experienced chronic gastrointestinal symptoms in their lifetime (91%), but congenital gastrointestinal malformations (3.5%) and gastrointestinal autoimmune diseases (1.5%) were uncommon. Chronic symptoms without anatomic or pathologic abnormalities represented the vast burden of illness. Chronic symptoms in adulthood are associated with other chronic gastrointestinal symptoms and psychiatric comorbidities ( P < 0.01) but not with deletion size or physiologic comorbidities ( P > 0.05). One exception was increased nausea/vomiting in hypothyroidism ( P = 0.002). CONCLUSIONS: Functional gastrointestinal disorders (FGIDs) are a common cause of ill health in children and adults with 22q11.2DS. Providers should consider screening for the deletion in patients presenting with FGIDs and associated comorbidities such as neuropsychiatric illness, congenital heart disease, and palatal abnormalities.

A Comprehensive Analysis of the Genetic Diversity of Plasmodium falciparum Histidine-Rich Protein 2 (PfHRP2) in the Brazilian Amazon.

Early diagnosis and treatment are fundamental to the control and elimination of malaria. In many endemic areas, routine diagnosis is primarily performed microscopically, although rapid diagnostic tests (RDTs) provide a useful point-of-care tool. Most of the commercially available RDTs detect histidine-rich protein 2 (HRP2) of Plasmodium falciparum in the blood of infected individuals. Nonetheless, parasite isolates lacking the pfhrp2 gene are relatively frequent in some endemic regions, thereby hampering the diagnosis of malaria using HRP2-based RDTs. To track the efficacy of RDTs in areas of the Brazilian Amazon, we assessed pfhrp2 deletions in 132 P. falciparum samples collected from four malaria-endemic states in Brazil. Our findings show low to moderate levels of pfhrp2 deletion in different regions of the Brazilian Amazon. Overall, during the period covered by this study (2002-2020), we found that 10% of the P. falciparum isolates were characterized by a pfhrp2 deletion. Notably, however, the presence of pfhrp2-negative isolates has not been translated into a reduction in RDT efficacy, which in part may be explained by the presence of polyclonal infections. A further important finding was the discrepancy in the proportion of pfhrp2 deletions detected using two assessed protocols (conventional PCR versus nested PCR), which reinforces the need to perform a carefully planned laboratory workflow to assess gene deletion. This is the first study to perform a comprehensive analysis of PfHRP2 sequence diversity in Brazilian isolates of P. falciparum. We identified 10 PfHRP2 sequence patterns, which were found to be exclusive of each of the assessed regions. Despite the small number of PfHRP2 sequences available from South America, we found that the PfHRP2 sequences identified in Brazil and neighboring French Guiana show similar sequence patterns. Our findings highlight the importance of continuously monitoring the occurrence and spread of parasites with pfrhp2 deletions, while also taking into account the limitations of PCR-based testing methods associated with accuracy and the complexity of infections.

Standardized Feeding Approach Mitigates Weight Loss in Infants with Congenital Heart Disease.

OBJECTIVE: To evaluate the effect of a standardized feeding approach using a clinical nutrition pathway on weight-for-age Z score (WAZ) over hospital length of stay (HLOS) for infants with congenital heart disease (CHD). STUDY DESIGN: A 10-year retrospective cohort study examined eligible infants who underwent neonatal cardiac surgery between July 2009 and December 2018 (n = 987). Eligibility criteria included infants born at least 37 weeks of gestation and a minimum birth weight of 2 kg who underwent cardiac surgery for CHD within the first 30 days of life. Using the best linear unbiased predictions from a linear mixed effects model, WAZ change over HLOS was estimated before and after January 2013, when the standardized feeding approach was initiated. The best linear unbiased predictions model included adjustment for patient characteristics including sex, race, HLOS, and class of cardiac defect. RESULTS: The change in WAZ over HLOS was significantly higher from 2013 to 2018 than from 2009 to 2012 (ß = 0.16; SE = 0.02; P < .001), after controlling for sex, race, HLOS, and CHD category, indicating that infants experienced a decreased WAZ loss over HLOS after the standardized feeding approach was initiated. Additionally, differences were found in WAZ loss over HLOS between infants with single ventricle CHD (ß = 0.26; SE = 0.04; P < .001) and 2 ventricle CHD (ß = 0.04; SE = 0.02; P = .04). CONCLUSIONS: These data suggest that an organized, focused approach for nutrition therapy using a standardized pathway improves weight change outcomes before hospital discharge for infants with single and 2 ventricle CHD who require neonatal cardiac surgery.

Nephrotic syndrome after insect sting: a case report / Síndrome nefrótica após picada de inseto: relato de caso

ABSTRACT Minimal change disease accounts for up to 25% of the cases of nephrotic syndrome in adult population. The allergic mechanism has been associated with minimal change disease and allergens have been implied, namely insect stings. We present a case report of a woman with new onset of nephrotic syndrome after a non-hymenoptera insect sting, with biopsy-proven minimal change disease, that was accompanied by a pulmonary thromboembolism process. Complete remission with glucocorticoid therapy was observed, with sustained response for 6 months after discontinuation. A new exposure to insect sting in the same geographical region and season triggered a nephrotic syndrome relapse. Subsequent avoidance of the place resulted in a sustained remission for more than 4 years.

RESUMO A doença de lesões mínimas é responsável por até 25% dos casos de síndrome nefrótica na população adulta. O mecanismo alérgico tem sido associado à doença de lesão mínima a associada a alérgenos, como picadas de insetos. Apresentamos um caso de uma mulher com início recente de síndrome nefrótica após picada de inseto não himenóptero, com doença de lesões mínimas comprovada por biópsia, acompanhada por um processo de tromboembolismo pulmonar. A paciente teve remissão completa com glicocorticoides, com resposta sustentada por 6 meses após a interrupção do tratamento. Uma nova exposição à picada de inseto na mesma região geográfica e estação do ano provocou uma recaída da síndrome nefrótica. Evitar o local subsequentemente resultou em remissão sustentada por mais de 4 anos.

Nephrotic syndrome after insect sting: a case report.

Minimal change disease accounts for up to 25% of the cases of nephrotic syndrome in adult population. The allergic mechanism has been associated with minimal change disease and allergens have been implied, namely insect stings. We present a case report of a woman with new onset of nephrotic syndrome after a non-hymenoptera insect sting, with biopsy-proven minimal change disease, that was accompanied by a pulmonary thromboembolism process. Complete remission with glucocorticoid therapy was observed, with sustained response for 6 months after discontinuation. A new exposure to insect sting in the same geographical region and season triggered a nephrotic syndrome relapse. Subsequent avoidance of the place resulted in a sustained remission for more than 4 years.

Rhabdomyolysis as a manifestation of a metabolic disease: a case report. / Rabdomiólise como manifestação de uma doença metabólica: relato de caso.

Rhabdomyolysis is a process of muscle destruction that can present with varying clinical manifestations. In pediatric patients, its main etiology is infectious diseases. We present a previously healthy adolescent who was admitted to our emergency department with a four-day history of myalgia, muscle weakness and dark urine. At presentation, she was dehydrated. Blood analysis revealed acute renal failure and increased muscular enzymes. She was transferred to our pediatric intensive care unit. Medical therapies for correction of dehydration and the ionic and metabolic consequences of renal failure were performed. Due to oliguria, renal replacement therapy was initiated. An etiological investigation revealed a beta-oxidation defect. Metabolic diseases are a known cause of rhabdomyolysis. Muscular destruction should be diagnosed early in order to avoid its potential consequences. Generally, the treatment of rhabdomyolysis is conservative, although in some situations, a more invasive approach is needed.

Rabdomiólise como manifestação de uma doença metabólica: relato de caso / Rhabdomyolysis as a manifestation of a metabolic disease: a case report

RESUMO A rabdomiólise é um processo de destruição muscular com manifestações clínicas variáveis. Em pacientes pediátricos, tem como principal etiologia as doenças infecciosas. Apresentamos o caso de uma adolescente previamente saudável, que foi admitida ao nosso pronto-socorro com histórico de 4 dias com mialgia, fraqueza muscular e urina escura. Na avaliação inicial, apresentava-se desidratada. Os exames de sangue revelaram insuficiência renal aguda e aumento de enzimas musculares. A paciente foi transferida para nossa unidade de terapia intensiva pediátrica. Foi realizado tratamento clínico para correção da desidratação e das consequências iônicas e metabólicas da insuficiência renal. Em razão da oligúria, deu-se início à terapia de substituição renal. A investigação etiológica revelou um defeito da betaoxidação. Sabe-se que doenças metabólicas podem provocar rabdomiólise. A destruição muscular deve ser identificada precocemente, para evitar suas potenciais consequências. Em geral, o tratamento da rabdomiólise é conservador, embora em algumas situações seja necessária uma abordagem mais invasiva.

ABSTRACT Rhabdomyolysis is a process of muscle destruction that can present with varying clinical manifestations. In pediatric patients, its main etiology is infectious diseases. We present a previously healthy adolescent who was admitted to our emergency department with a four-day history of myalgia, muscle weakness and dark urine. At presentation, she was dehydrated. Blood analysis revealed acute renal failure and increased muscular enzymes. She was transferred to our pediatric intensive care unit. Medical therapies for correction of dehydration and the ionic and metabolic consequences of renal failure were performed. Due to oliguria, renal replacement therapy was initiated. An etiological investigation revealed a beta-oxidation defect. Metabolic diseases are a known cause of rhabdomyolysis. Muscular destruction should be diagnosed early in order to avoid its potential consequences. Generally, the treatment of rhabdomyolysis is conservative, although in some situations, a more invasive approach is needed.

Integrative Nutrition for Pediatrics.

Food is essential for life. Yet, poor food choices may cause poor health. Dietary manipulation is frequently integrated into the management of common chronic pediatric conditions. Parents seek dietary information to have more control over child's condition and to avoid side effects of medicine. This article reviews selected diets for a few common pediatric disorders including eczema, attention deficit hyperactivity disorder, headache and migraine, non-celiac gluten sensitivity, and irritable bowel syndrome.

The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid-base balance in a PICU population / Efeito do NaCl a 0,9% e do NaCl a 0,45% sobre o sódio, cloreto e equilíbrio ácido-base em uma população de UTIP

ABSTRACT OBJECTIVES: To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid-base balance in pediatric intensive care patients during the first 24 h of hospitalization. METHODS: A prospective randomized controlled study was performed, which allocated 233 patients to groups: (A) NaCl 0.9% or (B) NaCl 0.45%. Patients were aged 1 day to 18 years, had normal electrolyte concentrations, and suffered an acute insult (medical/surgical). Main outcome measured: change in plasma sodium. Parametric tests: t-tests, ANOVA, X 2 statistical significance level was set at a = 0.05. RESULTS: Group A (n = 130): serum Na increased by 2.91 (±3.9) mmol/L at 24 h (p < 0.01); 2% patients had Na higher than 150 mmol/L. Mean urinary Na: 106.6 (±56.8) mmol/L. No change in pH at 0 and 24 h. Group B (n = 103): serum Na did not display statistically significant changes. Fifteen percent of the patients had Na < 135 mmol/L at 24 h. The two fluids had different effects on respiratory and post-operative situations. CONCLUSIONS: The use of saline 0.9% was associated with a lower incidence of electrolyte disturbances.

RESUMO OBJETIVO: Estudar o efeito de dois fluidos de manutenção intravenosos sobre o sódio (Na) plasmático e o equilíbrio ácido-base em pacientes de terapia intensiva pediátrica durante as primeiras 24 horas de internação. MÉTODOS: Foi feito um estudo controlado randomizado prospectivo. Alocamos aleatoriamente 233 pacientes para os grupos: (A) NaCl a 0,9% e (B) NaCl a 0,45%. Os pacientes com um dia a 18 anos apresentavam concentrações normais de eletrólitos e sofriam de insulto agudo (médico/cirúrgico). Principal resultado: variação no sódio plasmático. Testes paramétricos: teste t, Anova, qui-quadrado. O nível de relevância estatística foi estabelecido em a = 0,05. RESULTADOS: Grupo A (n = 130): o Na sérico aumentou 2,91 (± 3,9) mmol L-1 em 24 h (p < 0,01); 2% dos pacientes apresentaram Na acima de 150 mmol L-1. Concentração média de Na na urina: 106,6 (± 56,8) mmol L-1. Sem alteração no pH em 0 e 24 horas. Grupo B (n = 103): o Na sérico não apresentou alterações estatisticamente significativas; 15% dos pacientes apresentaram Na < 135 mmol L-1 em 24 h. Os dois fluidos tiveram efeitos diferentes sobre as situações respiratória e pós-operatória. CONCLUSÃO: O uso de solução fisiológica a 0,9% foi associado à menor incidência de distúrbios eletrolíticos.

The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid-base balance in a PICU population.

OBJECTIVES: To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid-base balance in pediatric intensive care patients during the first 24h of hospitalization. METHODS: A prospective randomized controlled study was performed, which allocated 233 patients to groups: (A) NaCl 0.9% or (B) NaCl 0.45%. Patients were aged 1 day to 18 years, had normal electrolyte concentrations, and suffered an acute insult (medical/surgical). MAIN OUTCOME MEASURED: change in plasma sodium. Parametric tests: t-tests, ANOVA, X(2) statistical significance level was set at α=0.05. RESULTS: Group A (n=130): serum Na increased by 2.91 (±3.9)mmol/L at 24h (p<0.01); 2% patients had Na higher than 150 mmol/L. Mean urinary Na: 106.6 (±56.8)mmol/L. No change in pH at 0 and 24h. Group B (n=103): serum Na did not display statistically significant changes. Fifteen percent of the patients had Na<135 mmol/L at 24h. The two fluids had different effects on respiratory and post-operative situations. CONCLUSIONS: The use of saline 0.9% was associated with a lower incidence of electrolyte disturbances.

Vitamin B(12) status in children with cystic fibrosis and pancreatic insufficiency.

OBJECTIVES: Unexpectedly high serum B12 concentrations were noted in most study subjects with cystic fibrosis (CF) and pancreatic insufficiency (PI) participating in a nutrition intervention at the baseline evaluation. The objectives of this study were to determine dietary, supplement-based, and enzyme-based B12 intake, serum B12 concentrations, and predictors of vitamin B12 status in children with CF and PI. STUDY DESIGN: Serum B12 status was assessed in subjects (5-18 years) and categorized as elevated (serum B12 above reference range for age and sex [Hi-B12]) or within reference range (serum B12 within reference range for age and sex) for age and sex. Serum homocysteine, plasma B6, red blood cell folate, height, weight, and body mass index z scores, pulmonary function, energy, and dietary and supplement-based vitamin intake were assessed. RESULTS: A total of 106 subjects, mean age 10.4 ±â€Š3.0 years, participated in the study. Median serum B12 was 1083 pg/mL, with 56% in the Hi-B12 group. Dietary and supplement-based B12 intakes were both high representing 376% and 667% recommended dietary allowance (RDA), respectively. The Hi-B12 group had significantly greater supplement-based B12 intake than the serum B12 within reference range for age and sex group (1000% vs 583% RDA, P < 0.001). Multiple logistic regression analysis showed that high supplement-based B12 intake and age >12 years increased the risk of Hi-B12, whereas higher forced expiratory volume at 1 second (FEV1) decreased the risk (pseudo-R = 0.18, P < 0.001). CONCLUSIONS: Serum B12 was elevated in the majority of children with CF and PI. Supplement-based B12 intake was 6 to 10 times the RDA, and strongly predicted elevated serum B12 status. The health consequences of lifelong high supplement-based B12 intake and high serum B12 are unknown and require further study, as does the inversed correlation between serum B12 and forced expiratory volume at 1 second.

Fat-soluble vitamins in cystic fibrosis and pancreatic insufficiency: efficacy of a nutrition intervention.

OBJECTIVES: The aim of the study was to assess the impact of LYM-X-SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI). METHODS: Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (α-tocopherol, α-tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months. Dietary intake was determined using 3-day weighed food records and supplemental vitamin intake by a comprehensive questionnaire. RESULTS: A total of 58 subjects (32 boys, age 10.3 ± 2.9 years [mean ± standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed. After adjusting for dietary and supplemental vitamin intake, serum retinol increased 3.0 ± 1.4 µg/dL (coefficient ± standard error) (adjusted R2 = 0.02, P = 0.03) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of -6.0% ± 1.6% by 12 months (adjusted R2 = 0.15, P < 0.001). These changes occurred in both the LXS and placebo comparison groups. No changes in serum 25D or α-tocopherol were detected. Both nutrition interventions increased caloric intake a mean of 83 ± 666 kcal/day by 12 months. CONCLUSIONS: Vitamins A and K status improved, whereas vitamins D and E status was unchanged during 12 months of LXS and isocaloric placebo comparison supplement in children with CF and PI.

A percepção das mães sobre o apoio paterno: influência na duração do aleitamento materno / The maternal perception on paternal support: influence on the duration of breastfeeding / La percepción de las madres sobre el apoyo paterno: influencia en la duración de la lactancia materna

OBJETIVO: Estudo de coorte prospectiva dos bebês nascidos na cidade de Pelotas entre setembro de 2002 e maio de 2003, com o objetivo de avaliar a percepção das mães quanto ao apoio paterno e sua influência na duração do aleitamento materno (AM). MÉTODOS: A população inicial do estudo foi de 2.741 bebês, sendo que uma amostra aleatória de 30% destes foi acompanhada no 1º, 3º e 6º meses, baseada em cálculo amostral com um nível de significância de 95% e poder estatístico de 80% para detectar risco relativo de 2,0. Foram realizadas análises univariada e multivariada, sendo que somente as variáveis com p<0,05 foram consideradas associadas ao desfecho de forma significante. RESULTADOS: Observou-se que no 1º mês aproximadamente 10% dos bebês não estavam em AM. A baixa escolaridade paterna e a falta de participação do pai na amamentação foram variáveis associadas ao desmame no 1º mês. No 3º mês, constatou-se forte associação entre o desmame e a falta de apoio paterno. O fato de a mãe não viver com o companheiro e a menor escolaridade paterna foram variáveis também associadas ao desfecho. Já no 6º mês, não foi encontrada associação entre variáveis paternas e AM. CONCLUSÕES: Este estudo pode servir de subsídio para futuras políticas públicas em saúde, como também para incentivo à inserção da figura paterna nas consultas pré-natais, na atenção ao parto e no puerpério.

OBJECTIVE: A cohort prospective study of newborns in the city of Pelotas, Southern Brazil, between September 2002 and May 2003, which aims at evaluating the perception of mothers as to fatherly support and its influence in breastfeeding duration. METHODS: The initial population included 2,741 babies, and a random and representative sample of 30% was followed-up on the first, third, and sixth months, with a significance level of 95% and statistical power of 80% to detect a relative risk of 2.0. Univariate and multivariate analyses were applied. Variables with p<0.05 were considered as significantly associated with the outcome. RESULTS: In the first month, approximately 10% of infants were not breastfed. Low paternal schooling and lack of support during breastfeeding were associated with weaning in the first month. In the third month, a strong association between weaning and lack of paternal support was verified. The fact that the mother no longer lived with her partner and the number of years in school were also associated with the outcome. In the sixth month, no correlation was found between paternal variables and breastfeeding. CONCLUSIONS: The present study could be useful as a reference to future public health policies as well as an incentive to insert the paternal figure in the prenatal, labor, and postdelivery care.

OBJETIVO: Estudio de cohorte prospectivo de los bebés nacidos en la ciudad de Pelotas (Rio Grande do Sul, Brasil), entre septiembre de 2002 y mayo de 2003, con el objetivo de evaluar la percepción de las madres respecto al apoyo paterno y su influencia en la duración de la lactancia materna (LM). MÉTODOS: La población inicial del estudio fue de 2.741 bebés, siendo acompañada en el primero, tercero y sexto meses una muestra aleatoria y representativa de 30% de éstos, basada en cálculo muestral, con un nivel de significancia de 95% y poder estadístico de 80%, para detectar riesgo relativo de 2,0. Se realizaron análisis uni y multivariados, siendo que solamente las variables con p<0,05 fueron consideradas asociadas al desfecho de modo estadísticamente significante. RESULTADOS: Se observó que, en el primer mes, un 10% de los bebés no estaban en LM. La baja escolaridad paterna y la falta de participación del padre en la amamantación fueron asociadas al destete en el primer mes. En el tercer mes, se constató fuerte asociación entre el destete y la falta de apoyo paterno. El hecho de que la madre no vive con el compañero y la menor escolaridad paterna fueron variables también asociadas al desenlace. Ya en el sexto mes, no se encontró asociación entre variables paternas y LM. CONCLUSIONES: Este estudio puede servir de subsidio para futuras políticas públicas en salud, como también para incentivo a la inserción de la figura paterna en las consultas prenatales, en la atención al parto y en el puerperio.

Análise espacial dos dados do programa de profilaxia da raiva no município de Lauro de Freitas, Bahia, Brasil, no período de 1999-2004 / Geospatial analysis of the data of the rabies control program in Lauro de Freitas municipality, Bahia, Brazil, during 1999-2004 / Análisis espacial de los datos del programa de profilaxia de la rabia en Lauro de Freitas, Bahia, Brasil, en el período 1999-2004

A elevada letalidade e o número de pessoas vacinadas tornam a raiva umproblema de saúde pública mundial. Inadequados sistemas de informação e vigilância epidemiológica não permitem conhecer a magnitude real do problema. Geotecnologias aplicadas na saúde pública caracterizam e quantificam a exposição a doenças e seus possíveis determinantes, tendo a análise espacial como instrumento importante nesta avaliação.Este estudo objetivou traçar o perfil epidemiológico das agressões por animais, em Lauro de Freitas, Bahia, Brasil, entre 1999-2004, para identificar áreas de risco e subsidiar ações educativas efetivas e específicas para a prevenção da raiva. Observou-se aumento no registrode agressões, provavelmente pelo estímulo a notificação, sendo principalmente por cães, sem raça definida, com proprietário, nos finais de semana, especialmente nas férias de verão. A informação fornecida pelo paciente, durante o atendimento, possibilita erros na prescrição daprofilaxia da raiva humana. O estudo identificou que os Distritos Centro e Itinga apresentam maior densidade populacional, assim como maior número de ocorrência de agressões e incidências. Em análise espacial identificaram-se dois grupos de aglomerados de risco: o Distrito Centro eo aglomerado secundário composto pelos Distritos de Areia Branca e Itinga, localidades que devem ser identificadas como áreas prioritárias para o controle da raiva no município.

The high mortality rate and the number of people vaccinated make rabies aproblem of public health worldwide. Inadequate information and epidemiological surveillance do not reveal the real magnitude of the problem. Geo-technologies applied in public health characterize and quantify exposure to diseases and their risk factors, having spatial analysis as an important part in this evaluation. This study aimed to trace the epidemiological profile of attacks by animals in Lauro de Freitas, Bahia, Brazil, between the years 1999-2004, identifying areas of risk, thereby subsidizing effective educational and specific actions for prevention ofrabies in this county. There was an recorded increase of aggression in the period, probably by an increase in the reporting, mainly by dogs, without defined breed, with their owners, on weekends, especially during summer vacations. Evidence shows that the information providedby the patient during his appointment enable errors in prescription of human prophylaxis. The geo-processing and statistical analysis identified that the Central Districts and Itinga, have the highest population density, as well as many of the occurrence of attacks and incidents. Two groups of risks were identified, the Central District and a secondary cluster composed of two other Districts, Areia Branca and Itinga. These locations are identified as priority areas for control of rabies in Lauro de Freitas, Bahia, Brasil.

El alto índice de mortalidad y el número de personas vacunadas hacende la rabia un problema de salud pública en todo el mundo. Inadecuados sistemas de información y vigilancia epidemiológica no permiten conocer la magnitud real del problema. Geotecnologías aplicadas en la salud pública caracterizan y cuantifican la exposición a enfermedades y sus posibles determinantes, teniendo el análisis espacial, como herramientaimportante en la evaluación. Este estudio tuvo como objetivo determinar el perfil epidemiológico de las agresiones por animales, en Lauro de Freitas, Bahía, Brasil, entre 1999- 2004, para identificar zonas de riesgo y subsidiar acciones educativas efectivas y específicas para la prevención de la rabia. Se observó un aumento en el registro de las agresiones,probablemente debido al estimulo de la notificación, siendo estas, principalmente por perros, sin raza definida, con propietario, durante los fines de semana y especialmente durante las vacaciones de verano. La información proporcionada por el paciente, durante el tratamiento,lleva a errores en la prescripción de la profilaxia de la rabia humana. El estudio identificó que los Distritos Centro e Itinga, presentan una mayor densidad poblacional, así como un mayor número de ocurrencias e incidencias de agresion. En el análisis espacial se identificaran dosgrupos de aglomeración de riesgo: el primero incluye el Distrito Centro y el grupo secundario compuesto por los Distritos de Areia Branca e Itinga, localidades que deben ser identificados como áreas prioritarias para el control de la rabia en la ciudad.

Alimentação nos primeiros três meses de vida dos bebês de uma coorte na cidade de Pelotas, Rio Grande do Sul / Feeding during the first three months of life for infants of a cohort in Pelotas, Rio Grande do Sul, Brazil / Alimentación en los primeros tres meses de vida de los bebés de una coorte en la ciudad de Pelotas, Rio Grande do Sul (Brasil)

Estudar o padrão alimentar nos primeiros três meses de vida de crianças nascidas na cidade de Pelotas (RS). MÉTODOS: Estudo de coorte prospectivo com os bebês nascidos entre setembro de 2002 e maio de 2003, na cidade de Pelotas (RS). Incluíram-se 2.741 bebês nas maternidades e uma amostra aleatória de 30% acompanhada no primeiro e terceiro meses de vida. Foram realizadas análises uni, bi e multivariada. Somente as variáveis com p<0,05 foram consideradas associadas ao desfecho de forma significante. RESULTADOS: Foram acompanhados 951 bebês no primeiro mês, dos quais 60% estavam em aleitamento materno exclusivo e 10% já estavam desmamados. As variáveis associadas ao desmame, neste período, foram: tabagismo na gravidez, escolaridade do pai inferior a quatro anos e uso de chupeta. No terceiro mês, 940 crianças foram acompanhadas: 29% haviam desmamado, 39% recebiam leite materno exclusivo e 59% utilizavam mamadeira. Tabagismo materno, escolaridade paterna e uso de chupeta, mantiveram-se associados ao desmame precoce. Houve aumento do uso de chupeta de 56 para 66% do primeiro para o terceiro mês, respectivamente. CONCLUSÕES: Comparado a estudos anteriores, evidenciou-se melhora nos índices de aleitamento materno, embora ainda inferiores aos valores ideais preconizados pela Organização Mundial de Saúde, o que ressalta a necessidade de estimulação à prática de aleitamento materno exclusivo no pré-natal e nos primeiros meses de vida.

To study the feeding pattern in the first three months of babies born in the Pelotas city, in Sothern Brazil. METHODS: Prospective cohort study, with babies born between september 2002 and may 2003. Among 2,741 babies whose mothers were interviewed at the maternity ward, a random sample of 30% was followed up on the first and third months of age. Univariate, bivariate and multivariate analyses were applied. Variables with a p<0.05 were considered as associated. RESULTS: 951 babies were followed up on the first month, 60% were under exclusive maternal breastfeeding, and 10% were already weaned. Smoking during pregnancy, father's educational level lower than four years and the use of a pacifier were associated to weaning. On the third month, 29% had been weaned, 39% received maternal milk exclusively, and 59% were bottle fed. Smoking during pregnancy, father schooling and the use of a pacifier were associated with weaning. There was an increase in the pacifier use - from 56 to 66% between the first and the third month of life. CONCLUSIONS: When compared to previous studies, an improvement on the rates of breastfeeding was shown, though still lower than World Health Organization recommendations, which highlights the need for stimulation of exclusive breastfeeding during prenatal care and during the first months after birth.

Estudiar el estándar alimentar en los primeros tres meses de vida de niños nascidos en la ciudad de Pelotas (RS, Brasil). MÉTODOS: Estudio de coorte prospectivo con bebés nascidos entre septiembre de 2002 y mayo de 2003, en la ciudad de Pelotas (RS, Brasil). Se incluyó a 2.741 bebés en las maternidades y una muestra aleatoria de 30%, seguida en el primero y el tercero meses de vida. Se realizaron análisis uni, bi y multivariados, y solamente las variables con p<0,05 fueron consideradas asociadas al desfecho de modo estadísticamente significativo. RESULTADOS: Se siguió a 951 bebés el primer mes, de los que el 60% estaba en lactancia materna exclusiva y el 10% ya estaban desmamados. Las variables asociadas al destete en ese periodo fueron: tabaquismo en el embarazo, escolaridad del padre inferior a cuatro años y uso de chupete. En el tercer mes, 940 niños fueron seguidos: el 29% estaba desmamado, el 39% recibía leche materna exclusiva y el 59% usaba biberón. Tabaquismo materno, escolaridad paterna y uso de chupete se mantuvieron asociados al destete temprano. Hubo aumento del uso de chupete de 56 para 66% del primero para el tercer mes, respectivamente. CONCLUSIONES: Comparado a estudios anteriores, el presente estudio evidenció mejora en los índices de lactancia materna, aunque todavía inferiores a los valores ideales preconizados por la Organización Mundial de Salud, lo que pone de relieve la necesidad de estimulación práctica de lactancia materna exclusiva en el pre-natal y los primeros meses de vida.

Nutrition education for pediatric gastroenterology, hepatology, and nutrition fellows: survey of NASPGHAN fellowship training programs.

OBJECTIVES: The aim of the study was to assess the methodology and content of nutrition education during gastroenterology fellowship training and the variability among the different programs. METHODS: A survey questionnaire was completed by 43 fellowship training directors of 62 active programs affiliated to the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, including sites in the United States, Canada, and Mexico. The data were examined for patterns in teaching methodology and coverage of specific nutrition topics based on level 1 training in nutrition, which is the minimum requirement according to the published North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition fellowship training guidelines. RESULTS: The majority of the teaching was conducted by MD-degree faculty (61%), and most of the education was provided through clinical care experiences. Only 31% of the level 1 nutrition topics were consistently covered by >80% of programs, and coverage did not correlate with the size of the programs. Competency in nutrition training was primarily assessed through questions to individuals or groups of fellows (77% and 65%, respectively). Program directors cited a lack of faculty interested in nutrition and a high workload as common obstacles for teaching. CONCLUSIONS: The methodology of nutrition education during gastroenterology fellowship training is, for the most part, unstructured and inconsistent among the different programs. The minimum level 1 requirements are not consistently covered. The development of core curriculums and learning modules may be beneficial in improving nutrition education.

Banho humanizado em recém-nascidos prematuros de baixo peso em uma enfermaria canguru / Bath humanized in premature newborns with low weight in a kangaroo infirmary

O banho é considerado uma prática com alto nível de manipulação que gera desorganização e estresse ao recém-nascido (RN) de risco, pois este apresenta comportamentos que estão em amadurecimento. Objetivou-se investigar a adequação do banho humanizado nos RN prematuros e de baixo peso internados em uma enfermaria canguru, identificando suas contribuições para a resposta adaptativa ao ambiente. Trata-se de um estudo observacional de corte transversal desenvolvido com 35 RN internados numa maternidade em Maceió-AL, de abril a junho de 2009, utilizando a observação direta junto ao recurso da filmagem. Foi observada a presença de sinais de aproximação em todos os comportamentos, constatando que o banho humanizado favorece a auto-organização destes RN.

The bath is considered a practice with high level of manipulation that desorganizes and distresses the risk newborn (NB) infant, once the child exhibits behaviors that are still maturing. It was aimed to investigate the adequacy of the humanized bath in low weight premature infants samitted in a kangaroo nursery, identifying its contributions to the adaptive response related to environment. This is an observational cross-sectional study, developed with 35 NB admitted in a Maternity Hospital in Maceio-AL, from April to June 2009, which was used direct observation together film. Signs of approximation in the subsystems were observed, concluding that the humanized bath favors self-organization of these NB.

Geotecnologias na análise da população canina para o controle da raiva,Considerando fatores socioeconômicos e demográficos. Município de Lauro de Freitas (BA) 1999 -2004 / Geospatial analysis of canine population in relation to socioeconomic And demographic factors in Lauro de Freitas (BA), during 1999 -2004

A análise da população canina de um município representa um instrumento indispensável para o controle da raiva e outras zoonoses, que tenham o cão como reservatório.Este trabalho teve como objetivo analisar a população canina do município de Lauro de Freitas (BA), no período de 1999 a 2004, levando em conta os dados socioeconômicos e demográficos de cada distrito sanitário do município. Foi utilizado o histórico vacinal de Lauro de Freitas (BA) entre 1999 e 2004, e os dados do último Censo Demográfico no ano 2000. O estudo possibilitou o dimensionamento, localização e caracterização adequada da população canina. Foi constatado que a população canina estimada no período, conforme orientação do Ministério da Saúde estava subestimada em 25,7%, representando 15,7% da população humana. Verificou-se também grande variação da população canina entre os Distritos Sanitários, com maior concentração em Areia Branca (39,2%), área rural do município, onde as condições socioeconômicas eram inferiores e a menor no distrito de Ipitanga (2,7%), local com características de veraneio. Concluiu-se que a alta proporção de cães no município pode estar relacionada com o tipo de moradia, principalmente horizontal, com predominância de domicílio tipo casa.

The analysis of a municipality canine population is an indispensable for the control of rabies and other zoonosis, which have the dog as a reservoir. Demographic and socioeconomic factors were considered because the relation of those with the health condition of population has been widely mentioned in several studies. Geotechnology applications to public health matters allow better characterization and quantification of exposure to diseases and their possible risk factors. This study was based on the vaccination history in Lauro de Freitas, Bahia, Brazil (1999 to 2004) and on the last 2000 Population Census data. It noted that the canine population during that period was underestimated by 25,7% in relation to official estimate, representing 15,7% of human population, variation between the districts, with a greater concentration in the municipality s rural area of Areia Branca (39,2%), where the socioeconomic conditions were lower. The district of Ipitanga had the lowest percentage (2,7%). The high proportion of dogs in the place could be linked to the housing type, which is predominantly horizontal in structure.