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In a background of high genomic HIV-1 variability with a predominance of CRF11_cpx and CRF22_01A1, we have studied the emergence of resistance mutations in isolates from Central African patients at failure of d4T-AZT/3TC/NVP-EFV plus two at failure of a PI-including regimen; the resistance mutations observed are those which are expected on HIV-1 subtype B.

Anti-Retroviral Agents/pharmacology , Drug Resistance, Viral , HIV Infections/virology , HIV-1/drug effects , HIV-1/genetics , Mutation, Missense , Adolescent , Adult , Amino Acid Substitution/genetics , Anti-Retroviral Agents/therapeutic use , Central African Republic , Child , Child, Preschool , Genotype , HIV Infections/drug therapy , HIV-1/isolation & purification , Humans , Middle Aged , Molecular Sequence Data , Sequence Analysis, DNA , Treatment Failure , Young Adult

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