RESUMEN
A new neoflavonoid, named S(+)-3'-hydroxy-4',2,4,5-tetramethoxydalbergiquinol (1), and a new benzofuran, named (2S,3S)-5-hydroxy-6-methoxy-3-methyl-2-(4'-hydroxyphenyl)-2,3dihydrobenzofuran (4), together with two known neoflavonoids, were isolated from the heartwood of Dalbergia melanoxylon. Their structures were elucidated by a combination of spectroscopic methods and comparison with the literature. Compounds 1-4 were evaluated for inhibitory activity against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 6538, Salmonella enteri CMCC 50041 and Candida albicans ATCC 289065, which all exhibited inactive or weak activity.
Asunto(s)
Antiinfecciosos/aislamiento & purificación , Benzofuranos , Dalbergia/química , Flavonoides , Candida albicans/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Salmonella enterica , Análisis Espectral , Staphylococcus aureus/efectos de los fármacosRESUMEN
A new benzofuran compound, named 2-[5-hydroxy-4-methoxy-2-(3-p-henyl-trans-allyloxy)benzyl]-5-hydroxy-6-methoxy-3-phenylbenzofuran (1), together with (+)-obtusafuran (2) and isoparvifuran (3), was isolated from the heartwood of Dalbergia latifolia. Their structures were elucidated by a combination of spectroscopic methods and comparison with the literature. Compounds 2 and 3 were obtained from this plant for the first time. Compound 1 exhibited moderated antioxidant effect for scavenging 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical (IC50 = 96.7 ± 8.9 µM).
Asunto(s)
Benzofuranos/aislamiento & purificación , Dalbergia/química , Antioxidantes , Benzofuranos/química , Compuestos de Bifenilo , Depuradores de Radicales Libres , Estructura Molecular , Análisis Espectral , Relación Estructura-ActividadRESUMEN
Neoflavonoids are a kind of characteristic components in the Dalbergia genus. Based on the previous researches, 59 neoflavonoids have been obtained from the Dalbergia genus. According to their molecular skeleton, the neoflavonoids can be divided intodalbergiphenols, dalbergiones, dalbergins, benzophenones and other types. Modern research shows that neoflavonoids displayed a variety of pharmacological activities, such as anti-osteoporosis, anti-inflammatory, antitumor, anti-androgen, anti-allergic, antioxidation etc. This paper reviewed neoflavonoids and their pharmacological functions, which could provide the valuable reference for comprehensive utilization and new drug development in the Dalbergia genus.