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1.
Hypertension ; 38(6): 1451-5, 2001 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-11751734

RESUMEN

Congestive heart failure (CHF) is associated with an impaired flow-mediated vasodilation that reflects an impaired endothelial function. Limited information is available, however, on whether and to what extent this impairment is improved by pharmacological or nonpharmacological treatment. We measured radial artery diameter and blood flow by an echo-tracking Doppler device both at baseline and after 4 minutes of hand ischemia, which increases diameter through NO secretion mediated by an increase in flow and shear stress. Data were collected from 44 CHF patients (New York Heart Association class I to III) under standard treatment (diuretic, digitalis, and enalapril, 20 mg/d), in whom CHF severity was assessed by a cardiopulmonary stress test, and from 16 age- and sex-matched controls. CHF patients were then randomized to maintain for (A) 2 months of standard treatment (n=11), (B) treatment with double the ACE inhibitor dose (n=11), (C) standard treatment with an angiotensin II antagonist (losartan, 50 mg/d; n=11), or (D) standard treatment with bicycle training for 30 minutes, 3 times a week (n=11). At baseline, radial artery diameter and flow were similar in CHF patients and controls; CHF patients had a modest although significant impairment in flow increase (-36%) and a striking impairment (-78%) in diameter increase following the 4 minutes of ischemia. After 2 months, baseline diameter and flow remained unaltered in the 4 groups. After the 4 minutes of ischemia, radial artery flow and diameter increased as before in the group under standard treatment (A), whereas in the other 3 groups, the increase was significantly (P<0.05) and, for diameter, markedly (B, 83%; C, 92%; and D, 95%) greater. The vasodilatation induced by trinitroglycerin was similar in CHF and control subjects and not affected by treatments. In CHF, radial artery shows a marked reduction in flow-mediated vasodilation, reflecting impairment of endothelial function. This impairment can be markedly improved by treatments that effectively block the renin-angiotensin system either at ACE or at ACE plus angiotensin receptor level. This is the case also with nonpharmacological treatment of CHF.


Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/administración & dosificación , Enalapril/administración & dosificación , Terapia por Ejercicio , Insuficiencia Cardíaca/fisiopatología , Insuficiencia Cardíaca/terapia , Arteria Radial/fisiopatología , Vasodilatación/efectos de los fármacos , Angiotensina II/antagonistas & inhibidores , Velocidad del Flujo Sanguíneo , Esquema de Medicación , Ecocardiografía Doppler , Prueba de Esfuerzo , Femenino , Humanos , Losartán/uso terapéutico , Masculino , Persona de Mediana Edad , Arteria Radial/diagnóstico por imagen
2.
Hepatology ; 32(3): 569-73, 2000 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-10960451

RESUMEN

Iron overload is believed to have an adverse influence on the cardiovascular system and animal studies have shown that iron may be involved in the events that lead to atherosclerosis via an enhancement of smooth muscle cell proliferation, lipid oxidation, and free radical production. There are no data on the effect of iron overload on arterial structural and mechanical properties in humans. We measured wall thickness and distensibility (D) by ultrasonography of the radial artery in 12 patients with uncomplicated genetic hemochromatosis (GH) who were normotensive and without atherosclerotic plaques. Twelve age- and sex-matched patients were taken as controls. Nine patients were evaluated also after iron depletion. Wall thickness was greater in patients with GH than in controls (+50%, P <.01) whereas D was slightly reduced in the former group compared with the latter group, though the difference was not statistically significant. After iron depletion, a significant reduction of wall thickness and a significant increase in D were observed (-24% and +33%, P <.05 for both). Thus, in patients with hemochromatosis, arterial wall thickness is increased before the onset of cardiovascular complications. This alteration is reverted by iron depletion, which also can improve the initial and modest radial artery wall stiffening associated with this condition. Thus, functional and structural alterations in midsize muscle arteries may be an early abnormality of hemochromatosis.


Asunto(s)
Hemocromatosis/genética , Hemocromatosis/terapia , Hierro/metabolismo , Arteria Radial/diagnóstico por imagen , Adulto , Presión Sanguínea , Femenino , Hemocromatosis/diagnóstico por imagen , Hemocromatosis/fisiopatología , Humanos , Masculino , Valores de Referencia , Ultrasonografía
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