Clinicopathologic analysis of oral dermoid and epidermoid cysts: a Brazilian multicenter study.

Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed. A total of 105,077 biopsy records of oral and maxillofacial lesions from seven Brazilian oral pathology centers were analyzed. All cases diagnosed as oral DCs and ECs were reviewed, and clinical, demographic, and histopathological data were collected. The series comprised 32 DCs (31.4%) and 70 ECs (68.6%). Most of the DCs occurred on the floor of the mouth (n = 14; 45.2%) of women (n = 17; 53.1%) with a mean age of 34.6 ± 21.6 years. All DCs were lined partially or entirely by stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were observed in the fibrous capsule . Most of the ECs affected the labial mucosa (n = 20; 31.7%) of men (n = 39; 56.5%) with a mean age of 48.0±19.8 years. Microscopically, most ECs (n = 68; 97.1%) were lined entirely by stratified squamous epithelium. Two cysts (2.9%) showed areas of respiratory metaplasia. Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were also observed in the fibrous capsule. Conservative surgical excision was the treatment of choice in all cases. Oral DCs and ECs are uncommon and often clinically misdiagnosed lesions. Clinicians should consider DCs and ECs in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located on the floor of the mouth and labial mucosa.

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study.

The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

Clinicopathologic analysis of oral dermoid and epidermoid cysts: a Brazilian multicenter study

Abstract Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed. A total of 105,077 biopsy records of oral and maxillofacial lesions from seven Brazilian oral pathology centers were analyzed. All cases diagnosed as oral DCs and ECs were reviewed, and clinical, demographic, and histopathological data were collected. The series comprised 32 DCs (31.4%) and 70 ECs (68.6%). Most of the DCs occurred on the floor of the mouth (n = 14; 45.2%) of women (n = 17; 53.1%) with a mean age of 34.6 ± 21.6 years. All DCs were lined partially or entirely by stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were observed in the fibrous capsule . Most of the ECs affected the labial mucosa (n = 20; 31.7%) of men (n = 39; 56.5%) with a mean age of 48.0±19.8 years. Microscopically, most ECs (n = 68; 97.1%) were lined entirely by stratified squamous epithelium. Two cysts (2.9%) showed areas of respiratory metaplasia. Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were also observed in the fibrous capsule. Conservative surgical excision was the treatment of choice in all cases. Oral DCs and ECs are uncommon and often clinically misdiagnosed lesions. Clinicians should consider DCs and ECs in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located on the floor of the mouth and labial mucosa.

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study

Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10,381 cases and literature review.

The aim of this study was to investigate the epidemiological and clinical characteristics of chronic inflammatory periapical diseases in different regions of Brazil and to compare with data from the literature. A multicenter study was carried out in four Brazilian referral centers in oral diagnosis. Histopathological records were reviewed, and all cases diagnosed microscopically as periapical granuloma, radicular cyst, and periapical abscess were included. Demographic and clinical data were collected. Descriptive statistics and Pearson's chi-square test were performed. A total of 10,381 cases of chronic inflammatory periapical diseases were found (13.8% of 74,931 archived specimens) over a period of 65 years. Radicular cysts were the most common lesion (59.9%). Women (56.1%) with a mean age of 37.01 years old (range 13 to 100 ± 14.42) and people of white skin color (59.2%) were the most affected individuals by chronic inflammatory periapical diseases. The lesions were generally asymptomatic (28.1%), located in the maxilla (60.1%), and posterior region (49.8%). The radicular cysts were larger when compared to periapical granulomas (p < 0.001). The disagreement between the clinical and histopathological diagnoses was higher when the final diagnosis was a periapical granuloma (p < 0.001). Chronic inflammatory periapical diseases continue to be common lesions affecting mainly adults. This should be a consequence of the burden of untreated caries in permanent teeth. Women are more affected and radicular cyst was the most common lesion.

Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10, 381 cases and literature review

Abstract The aim of this study was to investigate the epidemiological and clinical characteristics of chronic inflammatory periapical diseases in different regions of Brazil and to compare with data from the literature. A multicenter study was carried out in four Brazilian referral centers in oral diagnosis. Histopathological records were reviewed, and all cases diagnosed microscopically as periapical granuloma, radicular cyst, and periapical abscess were included. Demographic and clinical data were collected. Descriptive statistics and Pearson's chi-square test were performed. A total of 10,381 cases of chronic inflammatory periapical diseases were found (13.8% of 74,931 archived specimens) over a period of 65 years. Radicular cysts were the most common lesion (59.9%). Women (56.1%) with a mean age of 37.01 years old (range 13 to 100 ± 14.42) and people of white skin color (59.2%) were the most affected individuals by chronic inflammatory periapical diseases. The lesions were generally asymptomatic (28.1%), located in the maxilla (60.1%), and posterior region (49.8%). The radicular cysts were larger when compared to periapical granulomas (p < 0.001). The disagreement between the clinical and histopathological diagnoses was higher when the final diagnosis was a periapical granuloma (p < 0.001). Chronic inflammatory periapical diseases continue to be common lesions affecting mainly adults. This should be a consequence of the burden of untreated caries in permanent teeth. Women are more affected and radicular cyst was the most common lesion.

Effects of a mucoadhesive formulation containing Curcuma longa L. on oral wound healing

Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation. (AU)

Cell cycle markers and apoptotic proteins in oral tongue squamous cell carcinoma in young and elderly patients.

The immunoexpression of p16, p53, and Bax in oral tongue squamous cell carcinoma (OTSCC) in young and elderly patients is assessed based on clinical and morphological parameters. The sample consists of 60 OTSCC cases: 30 in young (age ≤ 45 years) and 30 in elderly (age ≥ 60 years) patients. Clinical (tumor size, regional node metastasis, distant metastasis, and clinical stage) and morphological (histological grade of malignancy) parameters were evaluated. Immunohistochemical quantitative analysis was performed using anti-p16, anti-p53, and anti-Bax antibodies. None of the evaluated proteins exhibited statistically significant differences between young and elderly patients (p>0.05). There was a significant association of p16 immunoexpression with clinical parameters in elderly patients. There were no associations of p53 and Bax with any of the clinico-morphological parameters. Correlations between p16 and Bax and between p53 and Bax immunoexpression were observed in young patients (r = 0.363; p = 0.048) and in elderly patients (r = 0.433; p = 0.017), respectively. In conclusion, the assessed proteins could not be used to determine differences in the biological behavior of OTSCC between young and elderly patients. Therefore, all proteins activated the pro-apoptotic pathway of OTSCC in both groups.

Randomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis - phase I study.

Preclinical repeated-dose toxicity and efficiency studies developed by our group suggest the potential of FITOPROT in treating mucositis. This serious limiting side effect is observed at a rate of 40-100% in patients under antineoplastic therapy and despite different palliative measures and therapeutic agents have been investigated, still no therapy was completely successful. Therefore, this study aimed to establish the safety and recommended phase II dose of FITOPROT for the prevention and treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with head and neck cancer. Twenty healthy adult participants were randomized into two groups that received pre-established concentrations of the collutory: group 1 (FITOPROT A - mucoadhesive formulation containing 10 mg/mL of curcuminoids extract plus 20% v/v of Bidens pilosa L. extract) and group 2 (FITOPROT B - mucoadhesive formulation containing 20 mg/mL of curcuminoids extract, plus 40% v/v of Bidens pilosa L. extract). Participants rinsed their mouths with FITOPROT, three times daily, for ten consecutive days. No participant experienced toxicity or unacceptable discomfort and/or adverse reactions (CTCAE v5.0), with laboratory and clinical parameters under normal conditions. Side effects observed were low intensity and temporary mucosa/dental surface pigmentation (n = 7) and tooth sensitivity (n = 4), which disappeared after formulation use ceased. No significant cellular genotoxic effects were observed (p > 0.05), and micronuclei frequencies were not changed (p > 0.05). Biochemical assays reveled no altered levels of myeloperoxidase (p = 0.2268), malondialdehyde (p = 0.1188) nor nitric oxide (p = 0.5709) concentration, and no significant difference were found in the levels of pro-inflammatory cytokines (p > 0.05). Thus, FITOPROT demonstrated to be safe and tolerable in both tested doses and is suitable for evaluation in a phase II trial as treatment against OM.

Chondroblastic osteosarcoma mimicking periapical abscess.

CASE REPORT: The present report describes a case of chondroblastic osteosarcoma in the periapical region of teeth #29, #30, and #31 of an 18-year-old male. Clinical history showed self-reported discomfort in the right posterior gingiva for over a month. Physical examination showed a small expansion and redness of the right mandibular buccal and lingual cortical plates, but no signs of pain or inflammation were observed. All the teeth responded positively to pulp sensibility. Periapical and panoramic radiographs showed slight periapical radiolucency in the roots of teeth #29 and #30, clear periodontal ligament space widening, and evident loss of lamina dura. Incisional biopsy was performed, and based on microscopic findings the diagnosis of chondroblastic osteosarcoma was confirmed. CONCLUSIONS: Non-endodontic diseases associated with tooth root apex, such as chondroblastic osteosarcoma, should be included in differential diagnosis of jaw lesions that resemble periapical abscess.

Chondroblastic osteosarcoma mimicking periapical abscess

Abstract Lesions of non-endodontic origin may mimic periapical abscess. Osteosarcoma is a rare malignant lesion. Case report The present report describes a case of chondroblastic osteosarcoma in the periapical region of teeth #29, #30, and #31 of an 18-year-old male. Clinical history showed self-reported discomfort in the right posterior gingiva for over a month. Physical examination showed a small expansion and redness of the right mandibular buccal and lingual cortical plates, but no signs of pain or inflammation were observed. All the teeth responded positively to pulp sensibility. Periapical and panoramic radiographs showed slight periapical radiolucency in the roots of teeth #29 and #30, clear periodontal ligament space widening, and evident loss of lamina dura. Incisional biopsy was performed, and based on microscopic findings the diagnosis of chondroblastic osteosarcoma was confirmed. Conclusions Non-endodontic diseases associated with tooth root apex, such as chondroblastic osteosarcoma, should be included in differential diagnosis of jaw lesions that resemble periapical abscess.

Use of Bidens pilosa L. (Asteraceae) and Curcuma longa L. (Zingiberaceae) to treat intestinal mucositis in mice: Toxico-pharmacological evaluations.

INTRODUCTION: Several studies towards the development of an effective treatment for intestinal mucositis have been reported, since this condition represents a major problem in clinical oncology practice due to cytotoxic effects of chemotherapy. However standardized protocols and universally accepted treatment options are yet to be established. OBJECTIVES: Given above, this study evaluated the protective effects of a mucoadhesive formulation containing both Bidens pilosa L. (Asteraceae) (BP) and curcuminoids from Curcuma longa L. (Zingiberaceae) (CL) on intestinal mucositis induced by 5-fluoruoacil (5-FU) in mice. RESULTS: As expected, animals only treated with 5-FU (200 mg/kg) showed a significant reduction of 60.3 and 42.4% in villi and crypts size, respectively, when compared to control. On the other hand, the proposed therapeutic/prophylactic treatment with mucoadhesive formulations managed to reduce histopathologic changes in mice bearing mucositis, especially at 125 mg/kg BP + 15 mg/kg CL dose. The formulation promoted an increase of 275.5% and 148.7% for villi and crypts size, respectively. Moreover, chemotherapy-related weight loss was reduced by 7.4% following the treatment. In addition, an increase of 10 and 30.5% in red and white blood cells was observed when compared to 5-FU group. Furthermore, treatments with the mucoadhesive formulation containing BP/CL up modulated Ki-67 and Bcl-2 expression while reduced pro-apoptotic regulator Bax. The formulation also modulated inflammatory response triggered by 5-FU through reduction of 68% of myeloperoxidase activity and a 4-fold increase in anti-inflammatory IL-10 levels. In parallel, the oxidative stress via lipid peroxidation was reduced as indicated by decrease of 63% of malondialdehyde concentrations. Additionally, the new formulation presented low acute oral systemic toxicity, being classified in the category 5 (2000 mg/kg < LD50 < 5000 mg/kg) of the Globally Harmonized Classification System. CONCLUSIONS: This study showed an interesting potential of the mucoadhesive formulation of BP/CL for the treatment of 5-FU-induced intestinal mucositis. Given the perspectives for the development of a new medicine, clinical studies are in progress to better understand the protective effects of this innovative formulation in treating mucositis.

Epidermoid cyst: highlights on diagnosis and magnetic resonance imaging features / Cisto epidermóide: processo de diagnóstico e características das imagens por ressonância magnética

Purpose: Epidermoid and dermoid cysts are extremely rare developmental cysts of a benign nature, which may occur anywhere in the body, although about 7% are found in the head and neck. This article reports a clinical case of a patient who had an epidermoid cyst and its magnetic resonance imaging (MRI) features. Case report: This case discusses an epidermoid cyst in a 36-year-old woman complaining about speech difficulty. Clinical examination revealed an extensive swelling on the floor of the mouth. MRI findings showed a cystic homogenous lesion located underneath the mylohyoid muscle which was removed by surgery. Histological examination of the mass confirmed the diagnosis of an epidermoid cyst. Conclusion: We concluded that MRI was considered useful for a more accurate diagnosis prior to treatment.

Proposta: Cistos epidermóide e dermóide são cistos de desenvolvimento extremamente raros, de natureza benigna, que podem ocorrer em qualquer região do corpo e somente 7% são encontrados na região de cabeça e pescoço. Este artigo apresenta o caso clínico de uma paciente que possuía um cisto epidermóide juntamente com as características das imagens por ressonância magnética. Descrição do caso: Paciente do gênero feminino, 36 anos, apresentou-se com queixa de dificuldade de fonação e deglutição. O exame clínico intrabucal revelou uma extensa tumefação em soalho bucal. As imagens por ressonância magnética indicaram uma lesão de natureza cística, homogênea, de conteúdo sólido e localizada abaixo do músculo milohiódeo. A lesão foi enucleada e encaminhada para exame anatomopatológico, cujo diagnóstico foi compatível com cisto epidermóide. Conclusão: A imagem por ressonância magnética foi essencial para determinar as características da lesão de acordo com a sua localização anatômica.

O papel do laser de baixa intensidade e da cloredidina 0, 12% no tratamento da mucosite bucal em crianças leucêmicas submetidas à quimioterapia / The utilization of the low energy laser and chlorexidine 0, 12% in the management of oral mucositis due to chemotherapy unn children with leukemia

No tratamento das leucemias é utilizada a quimioterapia, que apresenta vários efeitos colaterais. A mucosite bucal é a principal causa de dor durante a quimioterapia e a complicação mais comum dotratamento para neoplasias hematológicas. Esse estudo teve o objetivo de avaliar o uso do laser debaixa intensidade e da clorexidina 0,12% no tratamento da mucosite bucal decorrente de quimioterapiaem crianças leucêmicas. A amostra foi constituída por 10 crianças (Grupo Experimental) com leucemia aguda submetidas à quimioterapia e portadoras de mucosite bucal Graus I, II ou III, atendidas noHospital Araújo Jorge da Associação de Combate ao Câncer em Goiás. Também fazia parte da amostra, dados de 24 prontuários de pacientes infantis com leucemia aguda, tratados no mesmo hospital, que apresentaram mucosite bucal como intercorrência do tratamento de quimioterapia. Os pacientes do Grupo Experimental foram aleatoriamente distribuídos para receber o tratamento 1 (clorexidina 0,12%) ou 2 (laser). A presença e o grau de mucosite eram avaliados pelo mesmo examinador. Para comparação, os dados de prontuários de pacientes previamente tratados foram registrados, sendo que para estes, era utilizado apenas o tratamento sintomático da mucosite bucal. Os registros, da mesma forma, eram anotados quanto à presença e grau de mucosite. A mucosite bucal foi menos freqüente e teve menor tempo de duração no grupo que recebeu tratamento (clorexidina ou laser) do que no gruposem tratamento. A associação das várias formas de tratamento (higiene bucal, clorexidina e laser) leva à redução do número de episódios de mucosite bem como menor duração das lesões

Chemotherapy, which presents several side effects, is used in the management of leukemia. Oral mucositis is the main cause of pain during chemotherapy and is the most common complication in the management of hematological cancer. The aim of the current study was to investigate the utilization of the low-energy laser and the use of chlorexidine 0,12% in the management of oral mucositis due to chemotherapy in children with leukemia. The study group was composed of 10 children with acute leukemia, who developed oral mucositis grade I, II, or III, and who underwent chemotherapy at the Araújo Jorge Hospital at the Combat Cancer Association of Goias. 24 case records of infant patients with acute leukemia, who were managed at the already mentioned hospital, and who developed oral mucositis as intercurrence of chemotherapy, were also included. The patients in the Study Group were randomized tobe treated with 1 (chlorexidine 0,12%) or 2 (laser). The presence and the degree of mucositis being evaluated by the same examiner. For comparison, data in the charts of patients previously treated were registered. For these patients, just the symptomatic treatment of the oral mucositis was used. The data about the presence and degree of mucositis were equally logged. Oral mucositis was less frequent and had a shorter period of duration in the treated group (chlorexidine or laser) than in the untreated group. The association of various forms of treatment (oral hygiene, chlorhexidine and laser) decreases the number of mucositis occurrences and shortens duration of the lesions

Candidíase associada ao uso de próteses totais / Candida associated denture stomatitis

A Candida albicans é um microorganismo relativamente comum na cavidade bucal e sua transformação em um agente infeccioso está normalmente relacionada com a predisposição do hospedeiro a fatores sistêmicos imunossupressores e a fatores locais como o uso de próteses mal adaptadas, falta de limpeza das próteses e higiene bucal deficiente. A proposta deste trabalho á fazer uma abordagem clínica sobre as manifestações bucais desta infecção e seu tratamento, com ênfase voltada para a candidíase associada ao uso de próteses dentais

Complicações bucais da quimioterapia e radioterapia no tratamento do câncer / Oral complications of chemotherapy and radiotherapy in cancer treatment

O câncer em geral tem apresentado uma alta incidência no decorrer dos anos. O seu tratamento consiste em inibir a proliferação excessiva de células neoplásicas, podendo incluir cirurgia, quimioterapia e/ou radioterapia. Esses dois últimos métodos acarretam efeitos colaterais, vários deles na cavidade bucal. É importante ressaltar que a irradiação provoca alterações bucais apenas quando atinge a região de cabeça e pescoço. Dentre estas, destacam-se: mucosite, xerostomia, neurotoxicidade, hipogeusia, trismo muscu-lar, osteorradionecrose, sangramento gengival, candidose, herpes labial e queilite angu-lar. Portanto, não só o câncer bucal afeta a boca, mas também a terapia dos diversos tipos de câncer. Assim, o objetivo desse trabalho é, através de uma ampla revisão de literatura, orientar o cirurgião-dentista no acompanhamento do paciente submetido à quimioterapia e/ou radioterapia na região de cabeça e pescoço e ressaltar a importância de sua participação numa equipe multidisciplinar para prevenir, diagnosticar, controlar e tratar os efeitos colaterais na boca. Dessa forma, pode-se oferecer qualidade de vida e aumentar as possibilidades de sucesso do tratamento, não só através do uso de medicamentos, mas também por meio da motivação do paciente, aprimorando suas habilidades para higienização e os cuidados com a saúde bucal. Observa-se que não há um protocolo padrão para o controle dessas complicações bucais, pela variedade de métodos e substâncias estudados e pesquisados para este fim.

Programa de de prevençäo do câncer bucal no município de Goiânia / Program of prevention of the oral cancer in the municipal district of Goiânia

No ano de 1996, foi desenvolvido no município de Goiânia um programa de prevençäo contra o câncer bucal cujas informaçöes eram transmitidas, à populaçäo em geral, através dos meios de comunicaçäo, palestras, painés o auto-exame bucal. Os pacientes eram examinados, conscientizados e, quando necessário, encaminhados para as clínicas da Faculdade de Odontologia - UFG e do Hospital Araújo Jorge. Os resultados mostraram que os pacientes ainda säo pouco informados sobre as consequências das neoplasias e que a eficácia e o sucesso de um programa de prevençäo contra o câncer bucal necessita, fundamentalmente, da ajuda dos programas de saúde bucal desenvolvido no Estado de Goiás

Cisto ósseo traumático: relato de caso / Traumatic bone cyst: case report

Os autores relataram um caso de cisto ósseo traumático localizado na regiäo de corpo mandibular direito em um paciente de 16 anos de idade. O tratamento instituído consistiu numa abordagem cirúrgica para exposiçäo da cavidade óssea e estabelecimento de sangramento em seu interior. Após 1 ano de "follow-up" houve completa neoformaçäo óssea na área.

Uso do Azul de Toluidina como método auxiliar da detecção de displasias epiteliais e carcinomas da mucosa bucal / Toluydine blue to detect epithelial dysplasia and oral mucosa carcinoma

Este trabalho visa determinar a sensibilidade, especificidade e eficácia do método da coloração "in vivo" do azul de toluidina na seleção dos sítios de biópsia em lesões cancerizáveis e/ou ulceradas da mucosa bucal, persistentes por mais de 14 dias. Foram selecionados 70 pacientes, sendo 55 do Serviço de Odontologia do Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás (Goiania-GO) e 15 do Serviço de Estomatologia e Prevenção do Câncer Bucomaxilofacial do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (Porto Alegre-RS). Dos 70 pacientes, 66 apresentavam lesão única, três apresentavam duas lesões e uma apresentava três lesões, perfazendo um total de 75 lesões evidenciadas neste estudo. As lesões foram submetidas à coloração com o azul de toluidina a 1 por cento, sendo que 53 (70,67 por cento) tiveram coloração positiva e 22 (29,33 por cento) não coraram. Todas as lesões foram biopsiadas, sendo escolhidas as áreas com coloração mais intensa nos casos onde a coloração foi positiva e nas lesões que não retiveram o corante, selecionou-se a área mais significativa de acordo com critérios clínicos. As peças foram devidamente processadas e os exames histopatológicos realizados sob microscopia óptica. Os resultados clínicos da coloração foram comparados com os diagnósticos histopatológicos e a partir da análise dos resultados, demonstrou-se que o método teve 100 por cento de sensibilidade, 53,66 por cento de especificidade e 74,67 por cento de eficácia