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Ukr Biokhim Zh (1999) ; 74(1): 97-100, 2002.
Article Uk | MEDLINE | ID: mdl-12199108

It has been shown, that the total X-ray irradiation in the dozes of 0.5 and 1 Gy influences on the content of lipid peroxidation products and enzymatic activity of antioxidant system in rat spleen and thymus cells. The influence of preparations "AMMIVIT" and "Ceruloplasmin" on these processes is investigated also. So, the animals feeding by the vitamin concentrate "AMMIVIT" have lead to increase of MDA level (a final product of lipid peroxidation) and the overactivity of some antioxidant enzymes in rat spleen and thymus cells. Injection of the preparation "Ceruloplasmin" to experimental animals up 1 hour before the irradiation has normalized LPO intensity and activity of AO enzymes.


Antioxidants/pharmacology , Ceruloplasmin/pharmacology , Lipid Peroxidation/drug effects , Animals , Antioxidants/metabolism , Dose-Response Relationship, Radiation , Male , Malondialdehyde/metabolism , Rats , Rats, Wistar , Spleen/metabolism , Spleen/radiation effects , Superoxide Dismutase/metabolism , Thymus Gland/metabolism , Thymus Gland/radiation effects
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