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Bioorg Med Chem
; 17(2): 621-4, 2009 Jan 15.
Article
En
| MEDLINE
| ID: mdl-19091578
Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.
Antiviral Agents/chemical synthesis , Capsid Proteins/antagonists & inhibitors , Pyridazines/chemical synthesis , Rhinovirus/drug effects , Antiviral Agents/pharmacology , Common Cold/drug therapy , Humans , Pyridazines/pharmacology , Structure-Activity Relationship