RESUMEN
White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.
Asunto(s)
Adhesión Celular , Diabetes Mellitus Tipo 2/sangre , Isquemia/sangre , Leucocitos/fisiología , Anciano , Isquemia Encefálica/sangre , Isquemia Encefálica/complicaciones , Antígenos CD11/sangre , Antígenos CD18/sangre , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Humanos , Isquemia/complicaciones , Selectina L/sangre , Leucocitos/inmunología , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/sangre , Isquemia Miocárdica/complicaciones , PronósticoAsunto(s)
Costos de los Medicamentos/legislación & jurisprudencia , Legislación de Medicamentos , National Institutes of Health (U.S.)/legislación & jurisprudencia , Preparaciones Farmacéuticas/economía , Apoyo a la Investigación como Asunto/legislación & jurisprudencia , Transferencia de Tecnología , Universidades/legislación & jurisprudencia , Financiación Gubernamental/legislación & jurisprudencia , National Institutes of Health (U.S.)/economía , Patentes como Asunto , Política , Estados Unidos , Universidades/economíaRESUMEN
BACKGROUND: Myocardial function is altered by many factors present in hemorrhaged and resuscitated animals. The purpose of this study was to determine whether resuscitation after a short period of hemorrhagic shock, which by itself did not alter intrinsic cardiac function, causes dysfunction. METHODS: Guinea pigs were instrumented to measure blood pressure and cardiac output, and several days later 50% of their blood volume was removed at a rate of 1 mL/min. Some animals were resuscitated with the shed blood and some with 6% dextran. Hearts were studied 1 or 24 hours after resuscitation. RESULTS: Isolated hearts from animals after 1 hour of resuscitation demonstrated dysfunction whether resuscitated with blood or dextran, although dysfunction was more severe with blood resuscitation. By 24 hours, dysfunction was essentially reversed. CONCLUSIONS: Resuscitation after hemorrhagic shock caused injury to the myocardium independent of the hemorrhage. Blood resuscitation resulted in greater dysfunction than did resuscitation with dextran.
